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Academic Journal

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles.

  • Authors : Lee SS; Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Center, University of Oxford, Oxford, United Kingdom.; Civitelli L

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/chemistry ; Brain*/Brain*/Brain*/metabolism

  • Source: ELife [Elife] 2024 Nov 25; Vol. 13. Date of Electronic Publication: 2024 Nov 25.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet

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Academic Journal

Liquid-liquid phase separation of alpha-synuclein increases the structural variability of fibrils formed during amyloid aggregation.

  • Authors : Ziaunys M; Institute of Biotechnology, Life Sciences Center, Vilnius University, Lithuania.; Sulskis D

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/chemistry ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/genetics

  • Source: The FEBS journal [FEBS J] 2024 Oct; Vol. 291 (20), pp. 4522-4538. Date of Electronic Publication: 2024 Aug 08.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Academic Journal

Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson's model.

  • Authors : Weiss F; School of Medical Sciences, Faculty of Medicine and Health and the Brain and Mind Centre, University of Sydney, Camperdown, NSW, 2050, Australia.; Hughes L

Subjects: Toll-Like Receptor 2*/Toll-Like Receptor 2*/Toll-Like Receptor 2*/metabolism ; Toll-Like Receptor 2*/Toll-Like Receptor 2*/Toll-Like Receptor 2*/genetics ; Astrocytes*/Astrocytes*/Astrocytes*/metabolism

  • Source: Translational neurodegeneration [Transl Neurodegener] 2024 Dec 16; Vol. 13 (1), pp. 62. Date of Electronic Publication: 2024 Dec 16.Publisher: BioMed Central Country of Publication: England NLM ID: 101591861 Publication Model: Electronic Cited Medium: Print ISSN: 2047-9158

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Academic Journal

Alpha-synuclein pathology in isolated rapid eye movement sleep behaviour disorder: a meta-analysis.

  • Authors : Iftikhar IH; Department of Medicine, Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.; Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.

Subjects: REM Sleep Behavior Disorder*/REM Sleep Behavior Disorder*/REM Sleep Behavior Disorder*/physiopathology ; REM Sleep Behavior Disorder*/REM Sleep Behavior Disorder*/REM Sleep Behavior Disorder*/cerebrospinal fluid ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/cerebrospinal fluid

  • Source: Journal of sleep research [J Sleep Res] 2024 Dec; Vol. 33 (6), pp. e14204. Date of Electronic Publication: 2024 Apr 08.Publisher: Published on behalf of the European Sleep Research Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9214441

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Academic Journal

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.

  • Authors : Jones-Tabah J; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada.

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/genetics ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2024 Nov 25; Vol. 19 (1), pp. 88. Date of Electronic Publication: 2024 Nov 25.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson's disease.

  • Authors : Jishi A; Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.; Hu D

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; Electron Transport Complex I*/Electron Transport Complex I*/Electron Transport Complex I*/metabolism ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/metabolism

  • Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Dec 21; Vol. 12 (1), pp. 198. Date of Electronic Publication: 2024 Dec 21.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960

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Academic Journal

Exploring Cimetidine as a Potential Therapeutic Attenuator against Amyloid Formation in Parkinson's Disease: Spectroscopic and Microscopic Insights into Alpha-Synuclein and Human Insulin.

  • Authors : Hassan MN; Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh 202001, India.; Ahmad A

Subjects: Cimetidine*/Cimetidine*/Cimetidine*/pharmacology ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/drug effects

  • Source: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Dec 18; Vol. 15 (24), pp. 4517-4532. Date of Electronic Publication: 2024 Dec 04.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Alpha-synuclein expression in neurons modulates Japanese encephalitis virus infection.

  • Authors : Gupta A; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.; Bohara VS

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/genetics ; Encephalitis Virus, Japanese*/Encephalitis Virus, Japanese*/Encephalitis Virus, Japanese*/physiology

  • Source: Journal of virology [J Virol] 2024 Dec 17; Vol. 98 (12), pp. e0041824. Date of Electronic Publication: 2024 Nov 07.Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Diverse effects of fluorescent labels on alpha-synuclein condensate formation during liquid-liquid phase separation.

  • Authors : Ziaunys M; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania. Electronic address: .; Sulskis D

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/chemistry ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; Fluorescent Dyes*/Fluorescent Dyes*/Fluorescent Dyes*/chemistry

  • Source: International journal of biological macromolecules [Int J Biol Macromol] 2024 Dec; Vol. 283 (Pt 2), pp. 137688. Date of Electronic Publication: 2024 Nov 15.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration.

  • Authors : Garcia Moreno SI; Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Limani F

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/genetics ; Dopaminergic Neurons*/Dopaminergic Neurons*/Dopaminergic Neurons*/metabolism

  • Source: Experimental neurology [Exp Neurol] 2024 Dec; Vol. 382, pp. 114959. Date of Electronic Publication: 2024 Sep 15.Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  108,634 results for ""alpha-Synuclein""