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Academic Journal

A potent Bioorganic azapodophyllotoxin derivative Suppresses tumor Progression in Triple negative breast Cancer: An Insight into its Inhibitory effect on tubulin polymerization and Disruptive effect on microtubule assembly.

  • Authors : Gupta S; Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur 440010, Maharashtra, India.; Dev J R A

Subjects: Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/drug therapy ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/pathology ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/metabolism

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Dec; Vol. 153, pp. 107839. Date of Electronic Publication: 2024 Sep 21.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines inhibit tubulin polymerisation and act as anticancer agents.

  • Authors : Wang C; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao University, Qingdao, China.

Subjects: Tubulin*/Tubulin*/Tubulin*/metabolism ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2286939. Date of Electronic Publication: 2023 Dec 11.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis, biological evaluation and mechanism study of a novel indole-pyridine chalcone derivative as antiproliferative agent against tumor cells through dual targeting tubulin and HK2.

  • Authors : Zheng M; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China.; Liu G

Subjects: Cell Proliferation*/Cell Proliferation*/Cell Proliferation*/drug effects ; Indoles*/Indoles*/Indoles*/pharmacology ; Indoles*/Indoles*/Indoles*/chemistry

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Jan 15; Vol. 282, pp. 117058. Date of Electronic Publication: 2024 Nov 16.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discovery of novel quinazoline derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potential anti-colon cancer effects.

  • Authors : Zhu L; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.; Zhang M

Subjects: Colchicine*/Colchicine*/Colchicine*/metabolism ; Colchicine*/Colchicine*/Colchicine*/pharmacology ; Colchicine*/Colchicine*/Colchicine*/chemistry

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 117000. Date of Electronic Publication: 2024 Oct 24.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Unveiling the anti-cancer potentiality of phthalimide-based Analogues targeting tubulin polymerization in MCF-7 cancerous Cells: Rational design, chemical Synthesis, and Biological-coupled Computational investigation.

  • Authors : Aljuhani A; Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia. Electronic address: .; Nafie MS

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemical synthesis ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Dec; Vol. 153, pp. 107827. Date of Electronic Publication: 2024 Sep 18.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Discovery of benzimidazole-2-amide BNZ-111 as new tubulin inhibitor.

  • Authors : Jang J; Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 34114, South Korea.; Koh B

Subjects: Benzimidazoles*/Benzimidazoles*/Benzimidazoles*/chemistry ; Benzimidazoles*/Benzimidazoles*/Benzimidazoles*/pharmacology ; Benzimidazoles*/Benzimidazoles*/Benzimidazoles*/chemical synthesis

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 15; Vol. 113, pp. 129953. Date of Electronic Publication: 2024 Sep 11.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation.

  • Authors : Shi C; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Yang B

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Nov 05; Vol. 277, pp. 116766. Date of Electronic Publication: 2024 Aug 13.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.

  • Authors : Wu C; Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.; Zhang L

Subjects: Pyrimidines*/Pyrimidines*/Pyrimidines*/pharmacology ; Pyrimidines*/Pyrimidines*/Pyrimidines*/chemistry ; Pyrimidines*/Pyrimidines*/Pyrimidines*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Oct 05; Vol. 276, pp. 116649. Date of Electronic Publication: 2024 Jul 04.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Design and bio-evaluation of novel millepachine derivatives targeting tubulin colchicine binding site for treatment of osteosarcoma.

  • Authors : Geng D; Department of Orthopaedics, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China; Department of Orthopaedics, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211166, China.

Subjects: Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/drug therapy ; Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/pathology ; Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/metabolism

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Oct; Vol. 151, pp. 107624. Date of Electronic Publication: 2024 Jul 09.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The cytotoxic natural compound erianin binds to colchicine site of β-tubulin and overcomes taxane resistance.

  • Authors : Yan W; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: .; Zhou Y

Subjects: Tubulin*/Tubulin*/Tubulin*/metabolism ; Tubulin*/Tubulin*/Tubulin*/chemistry ; Colchicine*/Colchicine*/Colchicine*/pharmacology

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107569. Date of Electronic Publication: 2024 Jun 17.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  457,762 results for ""Tubulin""