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Academic Journal

Understanding the Interaction Modes and Reactivity of Trimedoxime toward Mm AChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects.

  • Authors : de Castro AA; Department of Chemistry, Federal University of Lavras, 37200-000 Lavras, Brazil.; Polisel DA

Subjects: Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*chemistry ; Trimedoxime/Trimedoxime/Trimedoxime/*pharmacology ; Trimedoxime/Trimedoxime/Trimedoxime/*therapeutic use

  • Source: International journal of molecular sciences [Int J Mol Sci] 2020 Sep 05; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats.

  • Authors : Kassa J; a Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defense , Hradec Kralove , Czech Republic.; Misik J

Subjects: Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*therapeutic use ; Neuroprotective Agents/Neuroprotective Agents/Neuroprotective Agents/*therapeutic use ; Neurotoxicity Syndromes/Neurotoxicity Syndromes/Neurotoxicity Syndromes/*prevention & control

  • Source: Toxicology mechanisms and methods [Toxicol Mech Methods] 2017 Mar; Vol. 27 (3), pp. 236-243. Date of Electronic Publication: 2017 Jan 22.Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats.

  • Authors : Bloch-Shilderman E; Department of Pharmacology, Israel Institute for Biological Research, P.O. Box 19, 74100, Ness Ziona, Israel. .; Yacov G

Subjects: Antidotes/Antidotes/Antidotes/*administration & dosage ; Atropine/Atropine/Atropine/*administration & dosage ; Benactyzine/Benactyzine/Benactyzine/*administration & dosage

  • Source: Archives of toxicology [Arch Toxicol] 2019 May; Vol. 93 (5), pp. 1365-1384. Date of Electronic Publication: 2019 Feb 07.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma.

  • Authors : Karasova JZ; Department of Public Health, Faculty of Health Sciences, Defence University, Hradec Kralove, Czech Republic. ; Chladek J

Subjects: Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*pharmacokinetics ; Oximes/Oximes/Oximes/*pharmacokinetics ; Pyridinium Compounds/Pyridinium Compounds/Pyridinium Compounds/*pharmacokinetics

  • Source: Journal of applied toxicology : JAT [J Appl Toxicol] 2013 Jan; Vol. 33 (1), pp. 18-23. Date of Electronic Publication: 2011 Jun 30.Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A comparison of the neuroprotective efficacy of individual oxime (HI-6) and combinations of oximes (HI-6+trimedoxime, HI-6+K203) in soman-poisoned rats.

  • Authors : Kassa J; Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.; Karasova JZ

Subjects: Neuroprotective Agents/Neuroprotective Agents/Neuroprotective Agents/*therapeutic use ; Neurotoxicity Syndromes/Neurotoxicity Syndromes/Neurotoxicity Syndromes/*prevention & control ; Oximes/Oximes/Oximes/*therapeutic use

  • Source: Drug and chemical toxicology [Drug Chem Toxicol] 2011 Jul; Vol. 34 (3), pp. 233-9.Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain.

  • Authors : Karasova JZ; Department of Public Health, Faculty of Military Health Sciences, Trebesska 1575, Hradec Kralove, Czech Republic. ; Zemek F

Subjects: Brain/Brain/Brain/*metabolism ; Butanes/Butanes/Butanes/*isolation & purification ; Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*isolation & purification

  • Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2011 Apr 05; Vol. 54 (5), pp. 1082-7. Date of Electronic Publication: 2010 Nov 25.Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo.

  • Authors : Bajgar J; Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic. ; Karasova JZ

Subjects: Organophosphate Poisoning*; Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*blood ; Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*metabolism

  • Source: Chemico-biological interactions [Chem Biol Interact] 2010 Sep 06; Vol. 187 (1-3), pp. 287-90. Date of Electronic Publication: 2010 Feb 16.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786

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Academic Journal

A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.

  • Authors : Kassa J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.; Sepsova V

Subjects: Antidotes/Antidotes/Antidotes/*therapeutic use ; Chemical Warfare Agents/Chemical Warfare Agents/Chemical Warfare Agents/*toxicity ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity

  • Source: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2015 Apr; Vol. 116 (4), pp. 367-71. Date of Electronic Publication: 2014 Oct 24.Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843

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Academic Journal

The Evaluation of the Potency of Newly Developed Oximes (K727, K733) and Trimedoxime to Counteract Acute Neurotoxic Effects of Tabun in Rats.

  • Authors : Kassa J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic. .; Hatlapatková J

Subjects: Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity ; Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*pharmacology ; Nervous System/Nervous System/Nervous System/*drug effects

  • Source: Acta medica (Hradec Kralove) [Acta Medica (Hradec Kralove)] 2015; Vol. 58 (4), pp. 135-43.Publisher: Facultas Medica Hradec Kralove, Universitas Carolina Country of Publication: Czech Republic NLM ID: 9705947 Publication Model: Print Cited

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Academic Journal

Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos.

  • Authors : Antonijević B; Institute of Toxicological Chemistry, School of Pharmacy, University of Belgrade, Vojvode Stepe 450, Serbia and Montenegro. ; Bokonjić D

Subjects: Organophosphate Poisoning*; Dichlorvos/Dichlorvos/Dichlorvos/*poisoning ; Monocrotophos/Monocrotophos/Monocrotophos/*poisoning

  • Source: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2005 Feb; Vol. 96 (2), pp. 111-7.Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print Cited Medium: Print ISSN: 1742-7835 (Print)

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  • 1-10 of  949 results for ""Trimedoxime""