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Academic Journal

Cyclopamine modulates smoothened receptor activity in a binding position dependent manner.

  • Authors : Kim K; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Bansal PD

Subjects: Veratrum Alkaloids*/Veratrum Alkaloids*/Veratrum Alkaloids*/pharmacology ; Veratrum Alkaloids*/Veratrum Alkaloids*/Veratrum Alkaloids*/metabolism ; Smoothened Receptor*/Smoothened Receptor*/Smoothened Receptor*/metabolism

  • Source: Communications biology [Commun Biol] 2024 Sep 28; Vol. 7 (1), pp. 1207. Date of Electronic Publication: 2024 Sep 28.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition.

  • Authors : Wang J; Department of Pharmacy, School of Medicine, Shanghai University, Shanghai, 200444, People's Republic of China.; Cheng H

Subjects: STAT3 Transcription Factor*/STAT3 Transcription Factor*/STAT3 Transcription Factor*/antagonists & inhibitors ; STAT3 Transcription Factor*/STAT3 Transcription Factor*/STAT3 Transcription Factor*/metabolism ; Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/metabolism

  • Source: Drug design, development and therapy [Drug Des Devel Ther] 2024 Nov 20; Vol. 18, pp. 5307-5322. Date of Electronic Publication: 2024 Nov 20 (Print Publication: 2024).Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Efcab7 deletion sensitizes mice to the teratogenic effects of gastrulation-stage alcohol exposure.

  • Authors : Fish EW; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, United States.; Boschen KE

Subjects: Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/genetics ; Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/metabolism ; Mice, Inbred C57BL*

  • Source: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2024 Dec; Vol. 130, pp. 108729. Date of Electronic Publication: 2024 Oct 02.Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model:

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Academic Journal

Mesenchymal stem cells-derived exosomes alleviate liver fibrosis by targeting Hedgehog/SMO signaling.

  • Authors : Zong R; Department of Physiology, School of Basic Medical Sciences, Wuhan University, 115 Donghu Road, Wuhan, 430071, China.; Zheng Y

Subjects: Exosomes*/Exosomes*/Exosomes*/metabolism ; Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/metabolism ; Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/metabolism

  • Source: Hepatology international [Hepatol Int] 2024 Dec; Vol. 18 (6), pp. 1781-1791. Date of Electronic Publication: 2024 Aug 13.Publisher: Springer Country of Publication: United States NLM ID: 101304009 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer.

  • Authors : Espinosa-Bustos C; Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile.; Bertrand J

Subjects: Smoothened Receptor*/Smoothened Receptor*/Smoothened Receptor*/antagonists & inhibitors ; Smoothened Receptor*/Smoothened Receptor*/Smoothened Receptor*/metabolism ; Purines*/Purines*/Purines*/chemistry

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Oct; Vol. 151, pp. 107681. Date of Electronic Publication: 2024 Jul 28.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Protein phosphatase 2A regulates blood cell proliferation and differentiation in Drosophila larval lymph glands.

  • Authors : Zhang F; Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China.; College of Marine Life Sciences, Ocean University of China, Qingdao, China.

Subjects: Cell Proliferation* ; Drosophila Proteins*/Drosophila Proteins*/Drosophila Proteins*/genetics ; Drosophila Proteins*/Drosophila Proteins*/Drosophila Proteins*/metabolism

  • Source: The FEBS journal [FEBS J] 2024 Oct; Vol. 291 (20), pp. 4558-4580. Date of Electronic Publication: 2024 Aug 26.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Academic Journal

BOC targets SMO to regulate the Hedgehog pathway and promote proliferation, migration, and invasion of glioma cells.

  • Authors : Wang S; Department of Medical Laboratory, Huhhot First Hospital, Hohhot, Inner Mongolia 010020, China.; Wang Y

Subjects: Cell Movement*/Cell Movement*/Cell Movement*/physiology ; Smoothened Receptor*/Smoothened Receptor*/Smoothened Receptor*/metabolism ; Smoothened Receptor*/Smoothened Receptor*/Smoothened Receptor*/genetics

  • Source: Brain research bulletin [Brain Res Bull] 2024 Oct 01; Vol. 216, pp. 111037. Date of Electronic Publication: 2024 Jul 30.Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The senescence-associated secretome of Hedgehog-deficient hepatocytes drives MASLD progression.

  • Authors : Jun JH; Division of Gastroenterology, Department of Medicine and.; Du K

Subjects: Hepatocytes*/Hepatocytes*/Hepatocytes*/metabolism ; Hepatocytes*/Hepatocytes*/Hepatocytes*/pathology ; Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2024 Aug 27; Vol. 134 (19). Date of Electronic Publication: 2024 Aug 27.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium:

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Academic Journal

mTORC1 hampers Hedgehog signaling in Tsc2 deficient cells.

  • Authors : Larsen LJ; Department of Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.; Østergaard E

Subjects: Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/metabolism ; Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/genetics ; Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/metabolism

  • Source: Life science alliance [Life Sci Alliance] 2024 Aug 26; Vol. 7 (11). Date of Electronic Publication: 2024 Aug 26 (Print Publication: 2024).Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet

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Academic Journal

Targeting Super-Enhancer-Driven Transcriptional Dependencies Suppresses Aberrant Hedgehog Pathway Activation and Overcomes Smoothened Inhibitor Resistance.

  • Authors : Sui Y; Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Subjects: Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/metabolism ; Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/genetics ; Smoothened Receptor*/Smoothened Receptor*/Smoothened Receptor*/genetics

  • Source: Cancer research [Cancer Res] 2024 Aug 15; Vol. 84 (16), pp. 2690-2706.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium:

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  • 1-10 of  3,145 results for ""Smoothened Receptor""