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Academic Journal

Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathway.

  • Authors : Kim DW; Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, and.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Subjects: Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/metabolism ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/genetics ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/pathology

  • Source: JCI insight [JCI Insight] 2024 Dec 20; Vol. 9 (24). Date of Electronic Publication: 2024 Dec 20.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium:

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Academic Journal

Linsitinib inhibits IGF-1-induced cell proliferation and hyaluronic acid secretion by suppressing PI3K/Akt and ERK pathway in orbital fibroblasts from patients with thyroid-associated ophthalmopathy.

  • Authors : Lee JY; Department of Pathology, Institute of Hansen's Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Lee SB

Subjects: Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/drug therapy ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/metabolism ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/pathology

  • Source: PloS one [PLoS One] 2024 Dec 18; Vol. 19 (12), pp. e0311093. Date of Electronic Publication: 2024 Dec 18 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Adipose-derived exosomes ameliorate skeletal muscle atrophy via miR-146a-5p/IGF-1R signaling.

  • Authors : Qin M; State Key Laboratory of Livestock and Poultry Breeding, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, No. 483 Wushan Road, Guangzhou, 510642, China.; Tianjin Hospital, Tianjin University, Tianjin, 300211, China.

Subjects: Exosomes*/Exosomes*/Exosomes*/metabolism ; MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics ; MicroRNAs*/MicroRNAs*/MicroRNAs*/metabolism

  • Source: Journal of nanobiotechnology [J Nanobiotechnology] 2024 Dec 18; Vol. 22 (1), pp. 754. Date of Electronic Publication: 2024 Dec 18.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155

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Academic Journal

Teprotumumab for the Treatment of Thyroid Eye Disease.

  • Authors : Ugradar S; Department of Orbit and Thyroid Eye Disease Thrive Health, Beverly Hills, CA, USA.; Malkhasyan E

Subjects: Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/drug therapy ; Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/therapeutic use ; Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/pharmacology

  • Source: Endocrine reviews [Endocr Rev] 2024 Nov 22; Vol. 45 (6), pp. 843-857.Publisher: Oxford University Press Country of Publication: United States NLM ID: 8006258 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Multi-layered proteomics identifies insulin-induced upregulation of the EphA2 receptor via the ERK pathway which is dependent on low IGF1R level.

  • Authors : Jørgensen SH; Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.; Global Research Technologies, Novo Nordisk A/S, 2760, Maaloev, Denmark.

Subjects: Receptor, EphA2*/Receptor, EphA2*/Receptor, EphA2*/metabolism ; Receptor, EphA2*/Receptor, EphA2*/Receptor, EphA2*/genetics ; Receptor, IGF Type 1*/Receptor, IGF Type 1*/Receptor, IGF Type 1*/metabolism

  • Source: Scientific reports [Sci Rep] 2024 Nov 21; Vol. 14 (1), pp. 28856. Date of Electronic Publication: 2024 Nov 21.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

PAPP-A as a Potential Target in Thyroid Eye Disease.

  • Authors : Conover CA; Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.; Bale LK

Subjects: Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/metabolism ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/pathology ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/drug therapy

  • Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Nov 18; Vol. 109 (12), pp. 3119-3125.Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Insulin-like growth factor 2 drives fibroblast-mediated tumor immunoevasion and confers resistance to immunotherapy.

  • Authors : Song D; Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Pharmacology, Chongqing Medical University, Chongqing, China.

Subjects: Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/genetics ; Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/metabolism ; Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2024 Nov 15; Vol. 134 (22). Date of Electronic Publication: 2024 Nov 15.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium:

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Academic Journal

Spontaneous Dimerization and Distinct Packing Modes of Transmembrane Domains in Receptor Tyrosine Kinases.

  • Authors : Levintov L; Department of Chemical Engineering and Bioengineering, University of New Hampshire, Durham, New Hampshire 03824, United States.; Gorai B

Subjects: Protein Multimerization* ; Receptor, IGF Type 1*/Receptor, IGF Type 1*/Receptor, IGF Type 1*/chemistry ; Receptor, IGF Type 1*/Receptor, IGF Type 1*/Receptor, IGF Type 1*/metabolism

  • Source: Biochemistry [Biochemistry] 2024 Oct 15; Vol. 63 (20), pp. 2692-2703. Date of Electronic Publication: 2024 Sep 25.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Chronic psychosocial stress affects insulin-like growth factor 1 and its receptors in mouse ovaries.

  • Authors : Igonina T; Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Siberia, Russia.; Lebedeva D

Subjects: Stress, Psychological*/Stress, Psychological*/Stress, Psychological*/metabolism ; Ovary*/Ovary*/Ovary*/metabolism ; Receptor, IGF Type 1*/Receptor, IGF Type 1*/Receptor, IGF Type 1*/metabolism

  • Source: Reproduction, fertility, and development [Reprod Fertil Dev] 2024 Oct; Vol. 36.Publisher: Commonwealth Scientific and Industrial Research Organisation Country of Publication: Australia NLM ID: 8907465 Publication Model: Print Cited

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Editorial & Opinion

Editorial expression of concern: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer.

  • Authors : Corcoran C; School of Pharmacy and Pharmaceutical Sciences & Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.; Rani S

Subjects: MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/genetics ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/pathology

  • Source: Molecular cancer [Mol Cancer] 2024 Oct 01; Vol. 23 (1), pp. 219. Date of Electronic Publication: 2024 Oct 01.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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  • 1-10 of  7,935 results for ""Receptor, IGF Type 1""