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Academic Journal

Generating Artificial Ribozymes Using Sparse Coevolutionary Models.

  • Authors : Calvanese F; Sorbonne Université, CNRS, Institut de Biologie Paris-Seine, Laboratoire de Biologie Computationnelle et Quantitative - LCQB Paris, Paris, France.; Laboratoire de Biophysique et Evolution, UMR CNRS-ESPCI 8231 Chimie Biologie Innovation, PSL Research University, ESPCI Paris, Paris, France.

Subjects: RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/genetics ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/metabolism ; Evolution, Molecular*

  • Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2847, pp. 217-228.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Academic Journal

Grand canonical Monte Carlo and deep learning assisted enhanced sampling to characterize the distribution of Mg2+ and influence of the Drude polarizable force field on the stability of folded states of the twister ribozyme.

  • Authors : Baral P; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, Baltimore, Maryland 21201, USA.; Sengul MY

Subjects: Magnesium*/Magnesium*/Magnesium*/chemistry ; Monte Carlo Method* ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/chemistry

  • Source: The Journal of chemical physics [J Chem Phys] 2024 Dec 14; Vol. 161 (22).Publisher: American Institute of Physics Country of Publication: United States NLM ID: 0375360 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Direct testing of natural twister ribozymes from over a thousand organisms reveals a broad tolerance for structural imperfections.

  • Authors : McKinley LN; Department of Chemistry, Pennsylvania State University, 104 Benkovic Building, 376 Science Drive, University Park, PA 16802, USA.; Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.

Subjects: RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/chemistry ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/metabolism ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/genetics

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Dec 11; Vol. 52 (22), pp. 14133-14153.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Minimal twister sister-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning.

  • Authors : Zhang Z; Institute for Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, China.; University of Science and Technology of China, Hefei, China.

Subjects: RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/genetics ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/metabolism ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/chemistry

  • Source: ELife [Elife] 2024 Dec 05; Vol. 12. Date of Electronic Publication: 2024 Dec 05.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet

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Academic Journal

Trans-cleaving hammerhead ribozyme in specific regions can improve knockdown efficiency in vivo.

  • Authors : Peng Y; Medical School, Fuyang Normal University, Fuyang, Anhui, China.; Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China.

Subjects: RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/metabolism ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/genetics ; Gene Knockdown Techniques*/Gene Knockdown Techniques*/Gene Knockdown Techniques*/methods

  • Source: Journal of cellular biochemistry [J Cell Biochem] 2024 Dec; Vol. 125 (12), pp. e30249. Date of Electronic Publication: 2022 Apr 11.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8205768 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Optimized periphery-core interface increases fitness of the Bacillus subtilis glmS ribozyme.

  • Authors : Yu LD; Program in Cell, Molecular and Developmental Biology and Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.; White EN

Subjects: Bacillus subtilis*/Bacillus subtilis*/Bacillus subtilis*/genetics ; Bacillus subtilis*/Bacillus subtilis*/Bacillus subtilis*/enzymology ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/chemistry

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Nov 27; Vol. 52 (21), pp. 13340-13350.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies.

  • Authors : Lindley SR; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.; Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Subjects: Dysferlin*/Dysferlin*/Dysferlin*/genetics ; Genetic Therapy*/Genetic Therapy*/Genetic Therapy*/methods ; Muscular Dystrophies*/Muscular Dystrophies*/Muscular Dystrophies*/therapy

  • Source: Science (New York, N.Y.) [Science] 2024 Nov 15; Vol. 386 (6723), pp. 762-767. Date of Electronic Publication: 2024 Nov 14.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

Ribozyme-Mediated Gene-Fragment Complementation for Nondestructive Reporting of DNA Transfer within Soil.

  • Authors : Selinidis MA; Department of BioSciences, Rice University, MS-140, 6100 Main Street, Houston, Texas 77005, United States.; Corliss AC

Subjects: RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/genetics ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/metabolism ; Escherichia coli*/Escherichia coli*/Escherichia coli*/genetics

  • Source: ACS synthetic biology [ACS Synth Biol] 2024 Nov 15; Vol. 13 (11), pp. 3539-3547. Date of Electronic Publication: 2024 Aug 15.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Elucidating Evolutionary Mechanisms and Variants of the Hammerhead Ribozyme Using In Vitro Selection.

  • Authors : Brill J; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.; Nurmi C

Subjects: RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/metabolism ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/chemistry ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/genetics

  • Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Nov 04; Vol. 25 (21), pp. e202400432. Date of Electronic Publication: 2024 Oct 04.Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Cofactor binding triggers rapid conformational remodelling of the active site of a methyltransferase ribozyme.

  • Authors : Jiang H; Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China and Institutes of Biomedical Sciences, Shanghai Medical College, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Subjects: RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/metabolism ; RNA, Catalytic*/RNA, Catalytic*/RNA, Catalytic*/chemistry ; Catalytic Domain*

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Nov; Vol. 300 (11), pp. 107863. Date of Electronic Publication: 2024 Oct 05.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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  • 1-10 of  12,149 results for ""RNA, Catalytic""