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Academic Journal

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors (2019-2023).

  • Authors : Nie MZ; School of Chemical Engineering and Pharmacy, Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan, 430205, China.; Zhang SS

Subjects: Pyrimidines*/Pyrimidines*/Pyrimidines*/chemistry ; Pyrimidines*/Pyrimidines*/Pyrimidines*/pharmacology ; Pyrimidines*/Pyrimidines*/Pyrimidines*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116973. Date of Electronic Publication: 2024 Oct 18.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses.

  • Authors : Jiang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; Zalloum WA

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116941. Date of Electronic Publication: 2024 Oct 05.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Fragment Addition-Based Design of Heteroaromatic-Biphenyl-DAPYs as Potent and Orally Available Non-nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Enhanced Safety.

  • Authors : Huang WJ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacokinetics

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Oct 10; Vol. 67 (19), pp. 17568-17584. Date of Electronic Publication: 2024 Oct 01.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Structure-based discovery of novel piperidine-biphenyl-DAPY derivatives as non-nucleoside reverse transcriptase inhibitors featuring improved potency, safety, and selectivity: From piperazine-biphenyl-DAPYs to piperidine-biphenyl-DAPYs.

  • Authors : Huang WJ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, China.

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Oct 05; Vol. 276, pp. 116668. Date of Electronic Publication: 2024 Jul 10.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

TAR RNA selective targeting ruthenium(II) complexes as HIV-1 reverse transcriptase inhibitors: On exploring structure-activity relationships of multiple positions.

  • Authors : Liu M; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, Yunnan University, Kunming 650050, PR China.; Xie DD

Subjects: Ruthenium*/Ruthenium*/Ruthenium*/chemistry ; HIV-1*/HIV-1*/HIV-1*/drug effects ; HIV-1*/HIV-1*/HIV-1*/enzymology

  • Source: Journal of inorganic biochemistry [J Inorg Biochem] 2024 Oct; Vol. 259, pp. 112664. Date of Electronic Publication: 2024 Jul 15.Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Investigating the role of nucleoside reverse transcriptase inhibitors in modulating lipotoxicity: Effects on lipid dynamics stress pathways, and insulin resistance on the function of dopaminergic neurons.

  • Authors : Lipke K; Department of Toxicology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland. Electronic address: .; Kubis-Kubiak A

Subjects: Insulin Resistance* ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Dopaminergic Neurons*/Dopaminergic Neurons*/Dopaminergic Neurons*/drug effects

  • Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Dec; Vol. 181, pp. 117701. Date of Electronic Publication: 2024 Dec 04.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

The latest developments in the design and discovery of non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of HIV.

  • Authors : Li J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.; Ye B

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Drug Design* ; Anti-HIV Agents*/Anti-HIV Agents*/Anti-HIV Agents*/pharmacology

  • Source: Expert opinion on drug discovery [Expert Opin Drug Discov] 2024 Dec; Vol. 19 (12), pp. 1439-1456. Date of Electronic Publication: 2024 Oct 13.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101295755 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Association between the CYP2B6 polymorphisms and nonnucleoside reverse transcriptase inhibitors drug-induced liver injury: a systematic review and meta-analysis.

  • Authors : Chanhom N; Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.; Sonjan J

Subjects: Cytochrome P-450 CYP2B6*/Cytochrome P-450 CYP2B6*/Cytochrome P-450 CYP2B6*/genetics ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/adverse effects ; Chemical and Drug Induced Liver Injury*/Chemical and Drug Induced Liver Injury*/Chemical and Drug Induced Liver Injury*/genetics

  • Source: Scientific reports [Sci Rep] 2024 Nov 27; Vol. 14 (1), pp. 29511. Date of Electronic Publication: 2024 Nov 27.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Nucleoside Reverse Transcriptase Inhibitors Are the Major Class of HIV Antiretroviral Therapeutics That Induce Neuropathic Pain in Mice.

  • Authors : Bush K; Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Wairkar Y

Subjects: Neuralgia*/Neuralgia*/Neuralgia*/drug therapy ; Neuralgia*/Neuralgia*/Neuralgia*/chemically induced ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/therapeutic use

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 21; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 21.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2- d ]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation.

  • Authors : Zhuo Z; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.; Wang Z

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 20; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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  • 1-10 of  89,579 results for ""REVERSE transcriptase inhibitors""