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Academic Journal

Study on the effects of rapamycin and the mTORC1/2 dual inhibitor OSI-027 on the metabolism of colon cancer cells based on UPLC-MS/MS metabolomics.

  • Authors : Fan K; Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou City, 215004, Jiangsu, People's Republic of China.; Wang Y

Subjects: Colonic Neoplasms*/Colonic Neoplasms*/Colonic Neoplasms*/drug therapy ; Colonic Neoplasms*/Colonic Neoplasms*/Colonic Neoplasms*/metabolism ; Imidazoles*/Imidazoles*/Imidazoles*/pharmacology

  • Source: Investigational new drugs [Invest New Drugs] 2024 Aug; Vol. 42 (4), pp. 418-427. Date of Electronic Publication: 2024 Jun 25.Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Inhibition of the rapamycin-insensitive mTORC1 /4E-BP1 axis attenuates TGF-β1-induced fibrotic response in human Tenon's fibroblasts.

  • Authors : Zou J; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.; Wu B

Subjects: Transforming Growth Factor beta1*/Transforming Growth Factor beta1*/Transforming Growth Factor beta1*/metabolism ; Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/metabolism ; Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors

  • Source: Experimental eye research [Exp Eye Res] 2024 Jul; Vol. 244, pp. 109927. Date of Electronic Publication: 2024 May 13.Publisher: Academic Press Country of Publication: England NLM ID: 0370707 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Rapamycin increases leukemia cell sensitivity to chemotherapy by regulating mTORC1 pathway-mediated apoptosis and autophagy.

  • Authors : Xu J; Department of Hematology, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, China.; Zong S

Subjects: Autophagy*/Autophagy*/Autophagy*/drug effects ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/metabolism

  • Source: International journal of hematology [Int J Hematol] 2024 May; Vol. 119 (5), pp. 541-551. Date of Electronic Publication: 2024 Mar 26.Publisher: Springer Japan Country of Publication: Japan NLM ID: 9111627 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles.

  • Authors : Ataman M; Biozentrum, University of Basel, Basel, Switzerland. .; Swiss Institute of Bioinformatics, Basel, Switzerland. .

Subjects: Caloric Restriction* ; Aging*/Aging*/Aging*/metabolism ; Sirolimus*/Sirolimus*/Sirolimus*/pharmacology

  • Source: Communications biology [Commun Biol] 2024 Aug 10; Vol. 7 (1), pp. 974. Date of Electronic Publication: 2024 Aug 10.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Effect of mTORC Agonism via MHY1485 with and without Rapamycin on C2C12 Myotube Metabolism.

  • Authors : Cook NE; Department of Health and Human Performance, High Point University, High Point, NC 27262-3598, USA.; McGovern MR

Subjects: Muscle Fibers, Skeletal*/Muscle Fibers, Skeletal*/Muscle Fibers, Skeletal*/metabolism ; Muscle Fibers, Skeletal*/Muscle Fibers, Skeletal*/Muscle Fibers, Skeletal*/drug effects ; Sirolimus*/Sirolimus*/Sirolimus*/pharmacology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 21; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 21.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Rapamycin Alleviates Neuronal Injury and Modulates Microglial Activation After Cerebral Ischemia.

  • Authors : Zhang Y; Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, No. 222 South Tianshui Road, Lanzhou, Gansu, 730000, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.

Subjects: Sirolimus*/Sirolimus*/Sirolimus*/pharmacology ; Microglia*/Microglia*/Microglia*/drug effects ; Microglia*/Microglia*/Microglia*/metabolism

  • Source: Molecular neurobiology [Mol Neurobiol] 2024 Aug; Vol. 61 (8), pp. 5699-5717. Date of Electronic Publication: 2024 Jan 15.Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons.

  • Authors : Arcas JM; Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Spain.; Oudaha K

Subjects: TRPM Cation Channels*/TRPM Cation Channels*/TRPM Cation Channels*/antagonists & inhibitors ; TRPM Cation Channels*/TRPM Cation Channels*/TRPM Cation Channels*/metabolism ; Sirolimus*/Sirolimus*/Sirolimus*/pharmacology

  • Source: British journal of pharmacology [Br J Pharmacol] 2024 Sep; Vol. 181 (17), pp. 3192-3214. Date of Electronic Publication: 2024 May 13.Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381

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Academic Journal

Rapamycin mitigates organ damage by autophagy-mediated NLRP3 inflammasome inactivation in sepsis.

  • Authors : Li X; Department of Infectious Diseases, Huzhou Central Hospital, Huzhou, PR China.; Zeng Q

Subjects: NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism ; Autophagy*/Autophagy*/Autophagy*/drug effects ; Sepsis*/Sepsis*/Sepsis*/drug therapy

  • Source: Histology and histopathology [Histol Histopathol] 2024 Sep; Vol. 39 (9), pp. 1167-1177. Date of Electronic Publication: 2024 Jan 09.Publisher: Histology and Histopathology Country of Publication: Spain NLM ID: 8609357 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.

  • Authors : Yan X; Department of Experimental Research, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China.

Subjects: Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/genetics ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism ; Sirolimus*/Sirolimus*/Sirolimus*/pharmacology

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Mar; Vol. 300 (3), pp. 105681. Date of Electronic Publication: 2024 Jan 23.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets.

  • Authors : Jhanwar-Uniyal M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.; Zeller SL

Subjects: Glioblastoma*/Glioblastoma*/Glioblastoma*/metabolism ; Sirolimus*/Sirolimus*/Sirolimus*/pharmacology ; Neoplastic Stem Cells*/Neoplastic Stem Cells*/Neoplastic Stem Cells*/metabolism

  • Source: Cells [Cells] 2024 Feb 27; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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  • 1-10 of  376,011 results for ""RAPAMYCIN""