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Academic Journal

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera.

  • Authors : Bond AG; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K.; Muñoz I Ordoño M

Subjects: Proteolysis* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/chemistry

  • Source: Journal of the American Chemical Society [J Am Chem Soc] 2024 Dec 11; Vol. 146 (49), pp. 33675-33711. Date of Electronic Publication: 2024 Nov 28.Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Proteolysis Targeting Chimeras (PROTACs) in Breast Cancer Therapy.

  • Authors : Jin Y; Department of Chemistry, Pusan National University, Busan, 46241, Korea.; Lee Y

Subjects: Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/drug therapy ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/metabolism ; Proteolysis*/Proteolysis*/Proteolysis*/drug effects

  • Source: ChemMedChem [ChemMedChem] 2024 Dec 02; Vol. 19 (23), pp. e202400267. Date of Electronic Publication: 2024 Oct 15.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187

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Academic Journal

Discovery of potent hypoxia-inducible factor-1α (HIF-1α) degraders by proteolysis targeting chimera (PROTAC).

  • Authors : Li Y; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Subjects: Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/antagonists & inhibitors ; Proteolysis*/Proteolysis*/Proteolysis*/drug effects

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Dec; Vol. 153, pp. 107943. Date of Electronic Publication: 2024 Nov 04.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Probing class I histone deacetylases (HDAC) with proteolysis targeting chimera (PROTAC) for the development of highly potent and selective degraders.

  • Authors : Ibrahim HS; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt. Electronic address: .

Subjects: Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/chemistry ; Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/pharmacology ; Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/chemical synthesis

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Dec; Vol. 153, pp. 107887. Date of Electronic Publication: 2024 Oct 12.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Cereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3.

  • Authors : Pavan AR; Leicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK. .; Smalley JP

Subjects: Proteolysis*/Proteolysis*/Proteolysis*/drug effects ; Histone Deacetylases*/Histone Deacetylases*/Histone Deacetylases*/metabolism ; Histone Deacetylases*/Histone Deacetylases*/Histone Deacetylases*/chemistry

  • Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Nov 21; Vol. 60 (94), pp. 13879-13882. Date of Electronic Publication: 2024 Nov 21.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability.

  • Authors : Wang Z; Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.; Institute of Integrated Bioinfomedicine and Translational Science (IBTS), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, China.

Subjects: Proto-Oncogene Proteins c-mdm2*/Proto-Oncogene Proteins c-mdm2*/Proto-Oncogene Proteins c-mdm2*/metabolism ; Proto-Oncogene Proteins c-mdm2*/Proto-Oncogene Proteins c-mdm2*/Proto-Oncogene Proteins c-mdm2*/antagonists & inhibitors ; Proteolysis*/Proteolysis*/Proteolysis*/drug effects

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 18865-18882. Date of Electronic Publication: 2024 Oct 22.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3.

  • Authors : Yang B; Tianjin University of Science and Technology, Tianjin 300457, China; Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, China. Electronic address: .

Subjects: Forkhead Transcription Factors*/Forkhead Transcription Factors*/Forkhead Transcription Factors*/metabolism ; Proteolysis*/Proteolysis*/Proteolysis*/drug effects; Humans

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 01; Vol. 112, pp. 129945. Date of Electronic Publication: 2024 Aug 31.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Advancing Proteolysis Targeting Chimera (PROTAC) Nanotechnology in Protein Homeostasis Reprograming for Disease Treatment.

  • Authors : Wu M; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.; Zhao Y

Subjects: Proteolysis*/Proteolysis*/Proteolysis*/drug effects; Humans ; Nanotechnology/Nanotechnology/Nanotechnology/methods

  • Source: ACS nano [ACS Nano] 2024 Oct 22; Vol. 18 (42), pp. 28502-28530. Date of Electronic Publication: 2024 Oct 08.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Proteolysis Targeting Chimera Agents (PROTACs): New Hope for Overcoming the Resistance Mechanisms in Oncogene-Addicted Non-Small Cell Lung Cancer.

  • Authors : Cordani N; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.; Nova D

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/genetics ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 18; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Computational methods and key considerations for in silico design of proteolysis targeting chimera (PROTACs).

  • Authors : Abbas A; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

Subjects: Proteolysis*; Computer Simulation ; Proteins/Proteins/Proteins/chemistry

  • Source: International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 277 (Pt 4), pp. 134293. Date of Electronic Publication: 2024 Jul 29.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  527,043 results for ""Proteolysis""