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Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition.

• Authors : Mikalkėnas A; a Department of Biochemistry and Molecular Biology, Institute of Biosciences, Life Sciences Center , Vilnius University , Vilnius , Lithuania.; Ravoitytė B

Subjects: DNA-Directed DNA Polymerase/DNA-Directed DNA Polymerase/DNA-Directed DNA Polymerase/*metabolism ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Nucleotides/Nucleotides/Nucleotides/*pharmacology

• Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 384-389.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Adenosine phosphonoacetic acid is slowly metabolized by NDP kinase.

• Authors : Chen Y; Laboratoire d'Enzymologie et de Biochimie Structurales, CNRS UPR 9063, Paris, France.; Morera S

Subjects: Adenosine/Adenosine/Adenosine/*analogs & derivatives ; Adenosine/Adenosine/Adenosine/*metabolism ; Adenosine Diphosphate/Adenosine Diphosphate/Adenosine Diphosphate/*analogs & derivatives

• Source: Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2005 Nov; Vol. 1 (6), pp. 529-36.Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101240303 Publication Model: Print Cited Medium: Print ISSN:

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A Salmonella Regulator Modulates Intestinal Colonization and Use of Phosphonoacetic Acid.

• Authors : Elfenbein JR; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University Health Science CenterBryan, TX, USA; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State UniversityRaleigh, NC, USA.

Subjects: Gene Expression Regulation, Bacterial*; Intestines/Intestines/Intestines/*microbiology ; Phosphonoacetic Acid/Phosphonoacetic Acid/Phosphonoacetic Acid/*metabolism

• Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2017 Mar 15; Vol. 7, pp. 69. Date of Electronic Publication: 2017 Mar 15 (Print Publication: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN:

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Discovery of a Phosphonoacetic Acid Derived Natural Product by Pathway Refactoring.

• Authors : Freestone TS; Department of Chemical and Biomolecular Engineering, ‡Carl R. Woese Institute for Genomic Biology, §Departments of Biochemistry, Bioengineering, and Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.; Ju KS

Subjects: Biological Products/Biological Products/Biological Products/*metabolism ; Phosphonoacetic Acid/Phosphonoacetic Acid/Phosphonoacetic Acid/*metabolism; Hydrolases/Hydrolases/Hydrolases/metabolism

• Source: ACS synthetic biology [ACS Synth Biol] 2017 Feb 17; Vol. 6 (2), pp. 217-223. Date of Electronic Publication: 2017 Jan 23.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet

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Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity.

• Authors : Manfredini S; Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy. ; Solaroli N

Subjects: Drug Design*; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemical synthesis

• Source: Antiviral chemistry & chemotherapy [Antivir Chem Chemother] 2003 Jul; Vol. 14 (4), pp. 183-94.Publisher: Sage Publications Country of Publication: England NLM ID: 9009212 Publication Model: Print Cited Medium: Print ISSN: 0956-3202 (Print)

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New Insights into DNA Polymerase Function Revealed by Phosphonoacetic Acid-Sensitive T4 DNA Polymerases.

• Authors : Zhang L; Marine Science & Technology Institute Department of Environmental Science and Engineering, Yangzhou University , No. 196 Huayang West Road, Hanjiang, Yangzhou, Jiangsu 225127, China.; Department of Biological Sciences, University of Alberta , Edmonton, Alberta T6G 2R3, Canada.

Subjects: Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Bacteriophage T4/Bacteriophage T4/Bacteriophage T4/*drug effects ; Bacteriophage T4/Bacteriophage T4/Bacteriophage T4/*enzymology

• Source: Chemical research in toxicology [Chem Res Toxicol] 2017 Nov 20; Vol. 30 (11), pp. 1984-1992. Date of Electronic Publication: 2017 Sep 15.Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet

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Agricola

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Agricola

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Agricola

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New Insights into DNA Polymerase Function Revealed by Phosphonoacetic Acid-Sensitive T4 DNA Polymerases.

• Authors : Likui Zhang

• Source: Chemical Research in Toxicology; 11/20/2017, Vol. 30 Issue 11, p1984-1992, 9p

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