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Academic Journal

Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation.

  • Authors : Pavlaki N; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Martinistr. 52, D-20246 Hamburg, Germany.

Subjects: Cyclic AMP*/Cyclic AMP*/Cyclic AMP*/metabolism ; Heart Failure*/Heart Failure*/Heart Failure*/enzymology ; Heart Failure*/Heart Failure*/Heart Failure*/genetics

  • Source: Cardiovascular research [Cardiovasc Res] 2024 Jul 31; Vol. 120 (9), pp. 1011-1023.Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245

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Academic Journal

PDE4 Phosphodiesterases in Cardiovascular Diseases: Key Pathophysiological Players and Potential Therapeutic Targets.

  • Authors : Puertas-Umbert L; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism ; Cardiovascular Diseases*/Cardiovascular Diseases*/Cardiovascular Diseases*/drug therapy; Humans

  • Source: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

PET imaging in rat brain shows opposite effects of acute and chronic alcohol exposure on phosphodiesterase-4B, an indirect biomarker of cAMP activity.

  • Authors : Tang S; Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.; Kim SW

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism ; Positron-Emission Tomography*/Positron-Emission Tomography*/Positron-Emission Tomography*/methods ; Brain*/Brain*/Brain*/drug effects

  • Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Dec; Vol. 50 (2), pp. 444-451. Date of Electronic Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

PDE4B inhibition by nerandomilast: Effects on lung fibrosis and transcriptome in fibrotic rats and on biomarkers in human lung epithelial cells.

  • Authors : Reininger D; Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.; Fundel-Clemens K

Subjects: Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/pharmacology ; Rats, Wistar* ; Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism

  • Source: British journal of pharmacology [Br J Pharmacol] 2024 Dec; Vol. 181 (23), pp. 4766-4781. Date of Electronic Publication: 2024 Aug 25.Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381

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Academic Journal

Structural and functional dynamics of human cone cGMP-phosphodiesterase important for photopic vision.

  • Authors : Singh S; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242.; Srivastava D

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 6*/Cyclic Nucleotide Phosphodiesterases, Type 6*/Cyclic Nucleotide Phosphodiesterases, Type 6*/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 6*/Cyclic Nucleotide Phosphodiesterases, Type 6*/Cyclic Nucleotide Phosphodiesterases, Type 6*/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 6*/Cyclic Nucleotide Phosphodiesterases, Type 6*/Cyclic Nucleotide Phosphodiesterases, Type 6*/chemistry

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jan 07; Vol. 122 (1), pp. e2419732121. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Aberrant TCF21 upregulation in adenomyosis impairs endometrial decidualization by increasing PDE4C expression.

  • Authors : Yu R; International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, China

Subjects: Endometrium*/Endometrium*/Endometrium*/metabolism ; Endometrium*/Endometrium*/Endometrium*/pathology ; Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism

  • Source: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2025 Jan; Vol. 1871 (1), pp. 167526. Date of Electronic Publication: 2024 Sep 25.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Mutations in the N-domain of aryl hydrocarbon receptor interacting protein affect interactions with heat shock protein 90β and phosphodiesterase 4A5.

  • Authors : Vella M; Department of Physiology & Biochemistry, Faculty of Medicine & Surgery, University of Malta, Msida, MSD2080, Malta.; Manfield IW

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/genetics ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/chemistry

  • Source: Biochimie [Biochimie] 2025 Jan; Vol. 228, pp. 114-126. Date of Electronic Publication: 2024 Sep 18.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

dCasMINI-mediated therapy rescues photoreceptors degeneration in a mouse model of retinitis pigmentosa.

  • Authors : Wang Q; Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94304, USA.; Xu X

Subjects: Retinitis Pigmentosa*/Retinitis Pigmentosa*/Retinitis Pigmentosa*/therapy ; Retinitis Pigmentosa*/Retinitis Pigmentosa*/Retinitis Pigmentosa*/genetics ; Retinitis Pigmentosa*/Retinitis Pigmentosa*/Retinitis Pigmentosa*/pathology

  • Source: Science advances [Sci Adv] 2024 Dec 20; Vol. 10 (51), pp. eadn7540. Date of Electronic Publication: 2024 Dec 18.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic

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Academic Journal

The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress.

  • Authors : Luo Y; Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People's Hospital, Nantong, Jiangsu, China.; Medical College of Nantong University, Nantong University, Nantong, Jiangsu, China.

Subjects: Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/genetics ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/metabolism ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/pathology

  • Source: Frontiers in immunology [Front Immunol] 2024 Nov 21; Vol. 15, pp. 1469740. Date of Electronic Publication: 2024 Nov 21 (Print Publication: 2024).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

PDE4D drives rewiring of the MAPK pathway in BRAF-mutated melanoma resistant to MAPK inhibitors.

  • Authors : Delyon J; Human Immunology Pathophysiology & Immunotherapy (HIPI), Université Paris Cité, INSERM U976 - Hôpital Saint Louis - 1 avenue Claude Vellefaux, Paris, 75010, France.; Université Paris Cité, AP-HP Dermato-oncology and CIC, Cancer institute APHP.nord Paris Cité, INSERM U976, Saint Louis Hospital, Paris, F-75010, France.

Subjects: Melanoma*/Melanoma*/Melanoma*/genetics ; Melanoma*/Melanoma*/Melanoma*/drug therapy ; Melanoma*/Melanoma*/Melanoma*/pathology

  • Source: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Nov 21; Vol. 22 (1), pp. 559. Date of Electronic Publication: 2024 Nov 21.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

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  • 1-10 of  65,817 results for ""PHOSPHODIESTERASES""