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Fragment Addition-Based Design of Heteroaromatic-Biphenyl-DAPYs as Potent and Orally Available Non-nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Enhanced Safety.

• Authors : Huang, Wen-Juan; Pannecouque, Christophe; De Clercq, Erik

• Source: Journal of Medicinal Chemistry; 10/10/2024, Vol. 67 Issue 19, p17568-17584, 17p

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Agricola

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Assessment of risk factors for virological nonsuppression following switch to dolutegravir and lamivudine, or bictegravir, emtricitabine, and tenofovir alafenamide fumarate in a real-world cohort of treatment-experienced adults living with HIV.

• Authors : Lee, Shu-Yuan¹ (AUTHOR); Lin, Yi-Chun¹ (AUTHOR); Chen, Cheng-Pin^1,2 (AUTHOR)

Subjects: *NUCLEOSIDE reverse transcriptase inhibitors; *NON-nucleoside reverse transcriptase inhibitors; *HIV

• Source: PLoS ONE. 11/20/2024, Vol. 19 Issue 11, p1-13. 13p.

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Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility.

• Authors : Zhao, Li-Min; Pannecouque, Christophe; Clercq, Erik De

Subjects: NON-nucleoside reverse transcriptase inhibitors; SOLUBILITY

• Source: Acta Pharmaceutica Sinica B; Dec2023, Vol. 13 Issue 12, p4906-4917, 12p

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Patent Issued for Composition and methods for treating articulating joint disorders with nucleoside reverse transcriptase inhibitors (USPTO 12121530)

• Source: Obesity, Fitness & Wellness Week. November 16, 2024, p870.

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Biochemical and structural comparisons of non-nucleoside reverse transcriptase inhibitors against feline and human immunodeficiency viruses.

• Authors : Siriluk Rattanabunyong; Khuanjarat Choengpanya; Chonticha Suwattanasophon

Subjects: EFAVIRENZ; NON-nucleoside reverse transcriptase inhibitors; HIV

• Source: Journal of Veterinary Science; Sep2023, Vol. 24 Issue 5, p1-15, 15p

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Agricola

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Nucleoside Reverse Transcriptase Inhibitors Are the Major Class of HIV Antiretroviral Therapeutics That Induce Neuropathic Pain in Mice.

• Authors : Bush, Keegan; Wairkar, Yogesh; Tang, Shao-Jun

Subjects: NUCLEOSIDE reverse transcriptase inhibitors; NON-nucleoside reverse transcriptase inhibitors; ANTI-HIV agents

• Source: International Journal of Molecular Sciences; Aug2024, Vol. 25 Issue 16, p9059, 14p

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Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses.

• Authors : Jiang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; Zalloum WA

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

• Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116941. Date of Electronic Publication: 2024 Oct 05.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Investigating the role of nucleoside reverse transcriptase inhibitors in modulating lipotoxicity: Effects on lipid dynamics stress pathways, and insulin resistance on the function of dopaminergic neurons.

• Authors : Lipke K; Department of Toxicology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland. Electronic address: .; Kubis-Kubiak A

Subjects: Insulin Resistance* ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Dopaminergic Neurons*/Dopaminergic Neurons*/Dopaminergic Neurons*/drug effects

• Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Dec; Vol. 181, pp. 117701. Date of Electronic Publication: 2024 Dec 04.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet

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