Search Results

A European consensus recommendation on the management of delayed methotrexate elimination: supportive measures, leucovorin rescue and glucarpidase treatment.

• Authors : Bielack, Stefan S.; Soussain, Carole; Fox, Christopher P.

Subjects: ANTINEOPLASTIC agents; METHOTREXATE; CARBOXYPEPTIDASES

• Source: Journal of Cancer Research & Clinical Oncology; Oct2024, Vol. 150 Issue 10, p1-12, 12p

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Intrathecal methotrexate, central nervous system toxicity, and response to N-methyl-D-aspartate antagonism: An adult case series.

• Authors : Donaghy, Ryan; Singer, Lauren; Dixit, Karan

Subjects: MAGNETIC resonance imaging; CENTRAL nervous system; WHITE matter (Nerve tissue)

• Source: Neuro-Oncology Practice; Oct2024, Vol. 11 Issue 5, p665-669, 5p

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Acute methotrexate toxicity in a patient with psoriasis: a case report.

• Authors : Abouzahir, Hind; Belhouss, Ahmed; Benyaich, Hicham

Subjects: PHYSICIANS; INTRAMUSCULAR injections; SEPTIC shock

• Source: Pan African Medical Journal; Jan-Apr2024, Vol. 47, p1-5, 5p

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Early intervention is important when administering glucarpidase for methotrexate intoxication. Author's reply.

• Authors : Miceli, G.¹ (AUTHOR) ; Daidone, M.¹ (AUTHOR); Corpora, F.¹ (AUTHOR)

Subjects: *METHOTREXATE; *AUTHORS

• Source: European Journal of Internal Medicine. Jun2024, Vol. 124, p152-153. 2p.

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Late administration of glucarpidase in methotrexate intoxication: Do we have more time than we thought?

• Authors : Miceli, G.¹ (AUTHOR) ; Daidone, M.¹ (AUTHOR); Corpora, F.¹ (AUTHOR)

Subjects: *METHOTREXATE

• Source: European Journal of Internal Medicine. Jan2024, Vol. 119, p144-145. 2p.

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Methotrexate-induced acute cardiotoxicity requiring veno-arterial extracorporeal membrane oxygenation support: a case report.

• Authors : Shah, Sareena; Haeger-Overstreet, Kristen; Flynn, Brigid

Subjects: EXTRACORPOREAL membrane oxygenation; HEART failure; CARDIOTOXICITY

• Source: Journal of Medical Case Reports; 11/29/2022, Vol. 16 Issue 1, p1-6, 6p

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Splenunculus mimicking splenomegaly in a patient with synchronous herpes simplex 1 viremia and myelosuppression.

• Authors : Paul, Dion A.; La, Paul Bao Duy; Abasszade, Joshua Haron

Subjects: HERPES simplex; MYELOSUPPRESSION; VIREMIA

• Source: Clinical Case Reports; Nov2022, Vol. 10 Issue 11, p1-4, 4p

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The Protective Effects of Nutraceutical Components in Methotrexate-Induced Toxicity Models—An Overview.

• Authors : Marin, Gheorghe-Eduard; Neag, Maria-Adriana; Burlacu, Codrin-Constantin

Subjects: TRIMETHYLAMINE oxide; NON-Hodgkin's lymphoma; TETRAHYDROFOLATE dehydrogenase

• Source: Microorganisms; Oct2022, Vol. 10 Issue 10, p2053-N.PAG, 23p

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Nephroprotective Potential of 1,3,4-Oxadiazole Derivative Against Methotrexate-Induced Nephrotoxicity in Rats by Upregulating Nrf2 and Downregulating NF-κB and TNF-α Signaling Pathways.

• Authors : Rafique Z; Department of Pharmacy,Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.; Aabid M

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Methotrexate*/Methotrexate*/Methotrexate*/adverse effects ; NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/metabolism

• Source: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2024 Dec; Vol. 38 (12), pp. e70084.Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461

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Taurine and enzymatically modified isoquercitrin protected against methotrexate-induced deteriorations in the conductivity and rhythmicity of the heart in rats: Antioxidant, anti-inflammatory, and histological architecture approach.

• Authors : Mahmoud MM; Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.; El-Batran SA

Subjects: Quercetin*/Quercetin*/Quercetin*/pharmacology ; Quercetin*/Quercetin*/Quercetin*/analogs & derivatives ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity

• Source: Journal of applied toxicology : JAT [J Appl Toxicol] 2024 Dec; Vol. 44 (12), pp. 1924-1935. Date of Electronic Publication: 2024 Aug 12.Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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STING signaling contributes to methotrexate-induced liver injury by regulating ferroptosis in mice.

• Authors : Wang HF; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: .; He YQ

Subjects: Ferroptosis*/Ferroptosis*/Ferroptosis*/drug effects ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Mice, Inbred C57BL*

• Source: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Nov 15; Vol. 287, pp. 117306. Date of Electronic Publication: 2024 Nov 14.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies.

• Authors : Ali GF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 62514, Egypt.; Hassanein EHM

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Methotrexate*/Methotrexate*/Methotrexate*/adverse effects; Humans

• Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Nov; Vol. 397 (11), pp. 8165-8188. Date of Electronic Publication: 2024 Jun 01.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Vinpocetine attenuates methotrexate-induced hippocampal intoxication via Keap-1/Nrf2, NF-κB/AP-1, and apoptotic pathways in rats.

• Authors : Alghamdi B; Department of Physiology, Neuroscience Unit, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.; Neuroscience and Geroscience Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Vinca Alkaloids*/Vinca Alkaloids*/Vinca Alkaloids*/pharmacology

• Source: Drug and chemical toxicology [Drug Chem Toxicol] 2024 Nov; Vol. 47 (6), pp. 1038-1049. Date of Electronic Publication: 2024 Mar 20.Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet

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Morinda officinalis iridoid glycosides alleviate methotrexate-induced liver injury in CIA rats by increasing liver autophagy and improving lipid metabolism homeostasis.

• Authors : Zhu L; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China; Department of Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310006, China.

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Morinda*/Morinda*/Morinda*/chemistry ; Lipid Metabolism*/Lipid Metabolism*/Lipid Metabolism*/drug effects

• Source: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Oct 28; Vol. 333, pp. 118486. Date of Electronic Publication: 2024 Jun 22.Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Evaluation the effects of Omega-3 and vitamin C alone or in combination on Methotrexate-Induced hepatotoxicity (in mice).

• Authors : Mohammed D; Department of Pharmacology, Mustansiriyah University, Baghdad, Iraq.; Al-Gareeb AM

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Methotrexate*/Methotrexate*/Methotrexate*/adverse effects ; Ascorbic Acid*/Ascorbic Acid*/Ascorbic Acid*/pharmacology

• Source: JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2024 Oct; Vol. 74 (10 (Supple-8)), pp. S414-S418.Publisher: Pakistan Medical Association Country of Publication: Pakistan NLM ID: 7501162 Publication Model: Print Cited Medium: Internet ISSN:

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Evaluation of concurrent use of Vitamin C and Niclosamide against methotrexate-induced liver injury in mice.

• Authors : Zeki Z; Department of Clinical Pharmacology, Mustansiriyah University, Baghdad, Iraq.; Abdulla Al-Gareeb AI

Subjects: Ascorbic Acid*/Ascorbic Acid*/Ascorbic Acid*/pharmacology ; Ascorbic Acid*/Ascorbic Acid*/Ascorbic Acid*/therapeutic use ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity

• Source: JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2024 Oct; Vol. 74 (10 (Supple-8)), pp. S419-S424.Publisher: Pakistan Medical Association Country of Publication: Pakistan NLM ID: 7501162 Publication Model: Print Cited Medium: Internet ISSN:

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Evaluation of the hepatoprotective effect of curcumin alone or in combination with vitamin C in methotrexate-induced hepatotoxicity in mice.

• Authors : Khudair DH; Department of Clinical Pharmacology and Therapeutics, Mustansiriyah University, Baghdad, Iraq.; Al-Gareeb AI

Subjects: Curcumin*/Curcumin*/Curcumin*/pharmacology ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Ascorbic Acid*/Ascorbic Acid*/Ascorbic Acid*/pharmacology

• Source: JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2024 Oct; Vol. 74 (10 (Supple-8)), pp. S442-S446.Publisher: Pakistan Medical Association Country of Publication: Pakistan NLM ID: 7501162 Publication Model: Print Cited Medium: Internet ISSN:

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Sitagliptin exhibits protective effects against methotrexate-induced testicular toxicity: The involvement of oxidative stress-related factors.

• Authors : Khezri MR; Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.; Pashaei MR

Subjects: Sitagliptin Phosphate*/Sitagliptin Phosphate*/Sitagliptin Phosphate*/pharmacology ; Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity

• Source: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2024 Oct; Vol. 129, pp. 108672. Date of Electronic Publication: 2024 Jul 21.Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model:

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Acute methotrexate toxicity in patients with psoriasis: case series.

• Authors : Ramesh, Heera; Kanathur, Shilpa; Loganathan, Eswari

Subjects: MORTALITY risk factors; HEPATOTOXICOLOGY -- Risk factors; PSORIASIS

• Source: Journal of the Egyptian Women's Dermatologic Society; May-Aug2022, Vol. 19 Issue 2, p137-140, 4p

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Effective Treatment of Methotrexate Induced Oral Mucositis With a Morphine Mouthwash Solution: A Case Report.

• Authors : Hosseini R; Department of Pharmacy Services, Harborview Medical Center - UW Medicine, Seattle, WA, USA.; Brooks SP

Subjects: Stomatitis*/Stomatitis*/Stomatitis*/chemically induced ; Stomatitis*/Stomatitis*/Stomatitis*/drug therapy ; Mouthwashes*

• Source: Journal of pharmacy practice [J Pharm Pract] 2025 Feb; Vol. 38 (1), pp. 212-216. Date of Electronic Publication: 2024 Aug 23.Publisher: Sage Publications Country of Publication: United States NLM ID: 8900945 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Successful Use of High Dose Methotrexate in Treatment of Primary CNS Lymphoma Patients Without Access to Serum Methotrexate Levels Monitoring: Challenges and Outcome.

• Authors : Singh, Charanpreet; Jain, Arihant; Takkar, Aastha

• Source: Indian Journal of Hematology & Blood Transfusion; Jan2022, Vol. 38 Issue 1, p68-77, 10p

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Evaluation of the Effect of Dibornol on the Level of DNA Damage in the DNA Comet Test In Vivo.

• Authors : Borovskaya TG; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. .; Vychuzhanina AV

Subjects: DNA Damage*/DNA Damage*/DNA Damage*/drug effects ; Comet Assay*/Comet Assay*/Comet Assay*/methods ; Rats, Wistar*

• Source: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Sep; Vol. 177 (5), pp. 635-638. Date of Electronic Publication: 2024 Sep 28.Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Can Alpha-Pinene Prevent Methotrexate-Induced Cardiac and Hepatic Damage?

• Authors : Cirrik S; Ordu University, Medical Faculty, Physiology Department, Ordu, Turkiye.; Hacioglu G

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Rats, Sprague-Dawley* ; Bicyclic Monoterpenes*/Bicyclic Monoterpenes*/Bicyclic Monoterpenes*/pharmacology

• Source: Physiological research [Physiol Res] 2024 Aug 31; Vol. 73 (4), pp. 621-631.Publisher: Published for the Institute of Physiology of the Czechoslovak Academy of Sciences by Academia, Pub. House of the Academy Country of Publication: Czech Republic

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The protective effect of Ozone on the mice testicular damage induced by methotrexate.

• Authors : Khorsandi L; Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/adverse effects ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Ozone*

• Source: JBRA assisted reproduction [JBRA Assist Reprod] 2024 Aug 26; Vol. 28 (3), pp. 464-470. Date of Electronic Publication: 2024 Aug 26.Publisher: Brazilian Society of Assisted Reproduction Country of Publication: Brazil NLM ID: 101684552 Publication Model: Electronic Cited Medium:

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Role of molecular adsorbent recirculating system in methotrexate-induced acute liver failure: a case report and literature review.

• Authors : Corbisier T; Pediatric and Neonatal Intensive Care Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospital of Geneva, University of Geneva, Geneva, Switzerland.; Von Bueren AO

• Source: Frontiers in pediatrics [Front Pediatr] 2024 Aug 15; Vol. 12, pp. 1424919. Date of Electronic Publication: 2024 Aug 15 (Print Publication: 2024).Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN:

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