Search Results

Loss of MER Tyrosine Kinase Attenuates Adipocyte Hypertrophy and Leads to Enhanced Thermogenesis in Mice Exposed to High-Fat Diet.

• Authors : Köröskényi K; Division of Dental Biochemistry, Department of Basic Medical Sciences, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Subjects: Diet, High-Fat*/Diet, High-Fat*/Diet, High-Fat*/adverse effects ; Thermogenesis*/Thermogenesis*/Thermogenesis*/drug effects ; Adipocytes*/Adipocytes*/Adipocytes*/metabolism

• Source: Cells [Cells] 2024 Nov 18; Vol. 13 (22). Date of Electronic Publication: 2024 Nov 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Discovery of Dual MER/AXL Kinase Inhibitors as Bifunctional Small Molecules for Inhibiting Tumor Growth and Enhancing Tumor Immune Microenvironment.

• Authors : Li MC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350401, Taiwan, ROC.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei City 115202, Taiwan, ROC.

Subjects: Tumor Microenvironment*/Tumor Microenvironment*/Tumor Microenvironment*/drug effects ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacology ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/chemistry

• Source: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 10906-10927. Date of Electronic Publication: 2024 Jun 24.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity.

• Authors : Huelse JM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA.; Bhasin SS

Subjects: c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/genetics ; c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/metabolism ; Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/immunology

• Source: Leukemia [Leukemia] 2024 Dec; Vol. 38 (12), pp. 2685-2698. Date of Electronic Publication: 2024 Sep 25.Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium:

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Ovarian expression of MerTK and its ligand Pros1 in non-pregnant estrus and pregnant mice.

• Authors : Kirimlioglu E; Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, Turkey. .; Cernomorcenco A

Subjects: c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/metabolism ; c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/genetics ; Ovary*/Ovary*/Ovary*/metabolism

• Source: Journal of molecular histology [J Mol Histol] 2024 Nov 29; Vol. 56 (1), pp. 12. Date of Electronic Publication: 2024 Nov 29.Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Electronic Cited Medium: Internet ISSN:

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Design and Development of Novel Hybrids Based on Pyrrolo[2,1-f][1,2,4]Triazine and 1-(Methylpiperidin-4-yl) Aniline-Based Analogs: Exploring the Utility as Anticancer Agents via MERTK Inhibition.

• Authors : Sathe BD; Department of Chemistry, Bharatiya Vidya Bhavan College, Chowpatty, Mumbai University, Mumbai, India.; Integral Biosciences Pvt Ltd., Drug Discovery Biotech, Noida, India.

Subjects: c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/metabolism ; c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/antagonists & inhibitors ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry

• Source: Chemical biology & drug design [Chem Biol Drug Des] 2024 Dec; Vol. 104 (6), pp. e70023.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285

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Murder at Chateau sur Mer.

• Authors : Maxwell, Alyssa, author

Subjects: Detective and mystery fiction; Historical fictionNewport (R.I.) -- Fiction

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NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis.

• Authors : Wei S; School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.; Qilu Zhongke Academy of Modern Microbiology Technology, Jinan, China.

Subjects: Liver Regeneration* ; NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/genetics

• Source: Science advances [Sci Adv] 2025 Jan 03; Vol. 11 (1), pp. eadq5786. Date of Electronic Publication: 2025 Jan 01.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic

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Clonal hematopoiesis JAKs up plaque formation.

• Authors : Campbell K; Department of Pathology.; Li Q

Subjects: Clonal Hematopoiesis*/Clonal Hematopoiesis*/Clonal Hematopoiesis*/genetics ; Janus Kinase 2*/Janus Kinase 2*/Janus Kinase 2*/genetics ; Janus Kinase 2*/Janus Kinase 2*/Janus Kinase 2*/metabolism

• Source: The Journal of clinical investigation [J Clin Invest] 2025 Jan 02; Vol. 135 (1). Date of Electronic Publication: 2025 Jan 02.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium:

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Big data analytics and scRNA-seq in human aortic aneurysms and dissections: role of endothelial MerTK.

• Authors : Liu S; Department of Biology, Georgia State University, Atlanta, GA, 30303, USA.; Wu J

Subjects: c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/metabolism ; c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/genetics ; Proto-Oncogene Mas*

• Source: Theranostics [Theranostics] 2025 Jan 01; Vol. 15 (1), pp. 202-215. Date of Electronic Publication: 2025 Jan 01 (Print Publication: 2025).Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet

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Anti-inflammatory effects of MerTK by inducing M2 macrophage polarization via PI3K/Akt/GSK-3β pathway in gout.

• Authors : Chen F; Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.

Subjects: c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/metabolism ; c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/genetics ; Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/metabolism

• Source: International immunopharmacology [Int Immunopharmacol] 2024 Dec 05; Vol. 142 (Pt A), pp. 112942. Date of Electronic Publication: 2024 Aug 31.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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