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Assessing Drug Sensitivity in Fission Yeast Using Half-Maximal Inhibitory Concentration (IC50) Assays.

• Authors : Chhipa MA; Molecular Science Program, Yeates School of Graduate Studies, Toronto Metropolitan University, Toronto, ON, Canada.; Sanayhie SA

Subjects: Schizosaccharomyces*/Schizosaccharomyces*/Schizosaccharomyces*/drug effects ; Schizosaccharomyces*/Schizosaccharomyces*/Schizosaccharomyces*/growth & development ; Inhibitory Concentration 50*

• Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2862, pp. 241-253.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Approved drugs successfully repurposed against Leishmania based on machine learning predictions.

• Authors : Oualha R; Laboratory of Molecular Epidemiology and Experimental Pathology - LR16IPT04, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia.; Abdelkrim YZ

Subjects: Drug Repositioning* ; Machine Learning* ; Antiprotozoal Agents*/Antiprotozoal Agents*/Antiprotozoal Agents*/pharmacology

• Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Sep 26; Vol. 14, pp. 1403589. Date of Electronic Publication: 2024 Sep 26 (Print Publication:Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN:

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Andrographolide induced cytotoxicity and cell cycle arrest in Giardia trophozoites.

• Authors : Haldar T; Division of Parasitology, ICMR-National Institute of Cholera and Enteric Diseases (ICMR-NICED), India.; Sardar SK

Subjects: Diterpenes*/Diterpenes*/Diterpenes*/pharmacology ; Giardia lamblia*/Giardia lamblia*/Giardia lamblia*/drug effects ; Giardia lamblia*/Giardia lamblia*/Giardia lamblia*/growth & development

• Source: Experimental parasitology [Exp Parasitol] 2024 Jul; Vol. 262, pp. 108773. Date of Electronic Publication: 2024 May 07.Publisher: Academic Press Country of Publication: United States NLM ID: 0370713 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Design, in silico study, synthesis and evaluation of hybrid pyrazole substituted 1,3,5-triazine derivatives for antimalarial activity.

• Authors : Borgohain P; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, 786004, India.; Shakya A

Subjects: Antimalarials*/Antimalarials*/Antimalarials*/pharmacology ; Antimalarials*/Antimalarials*/Antimalarials*/chemical synthesis ; Antimalarials*/Antimalarials*/Antimalarials*/chemistry

• Source: Experimental parasitology [Exp Parasitol] 2024 Jun; Vol. 261, pp. 108767. Date of Electronic Publication: 2024 Apr 26.Publisher: Academic Press Country of Publication: United States NLM ID: 0370713 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Incomplete Plasmodium falciparum growth inhibition following piperaquine treatment translates into increased parasite viability in the in vitro parasite reduction ratio assay.

• Authors : Walz A; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland.

Subjects: Plasmodium falciparum*/Plasmodium falciparum*/Plasmodium falciparum*/drug effects ; Plasmodium falciparum*/Plasmodium falciparum*/Plasmodium falciparum*/growth & development ; Quinolines*/Quinolines*/Quinolines*/pharmacology

• Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Apr 30; Vol. 14, pp. 1396786. Date of Electronic Publication: 2024 Apr 30 (Print Publication:Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN:

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Applied Science & Technology Full Text (H.W. Wilson)

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DFT based Computational Methodology of IC 50 Prediction.

• Authors : Bag A; Department of Applied Science Under School of Natural & Applied Sciences, Maulana Abul Kalam Azad University of Technology, West Bengal, Simhat, Haringhata, Nadia 741249, India.

Subjects: Computer Simulation* ; Inhibitory Concentration 50* ; Quantitative Structure-Activity Relationship*

• Source: Current computer-aided drug design [Curr Comput Aided Drug Des] 2021; Vol. 17 (2), pp. 244-253.Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101265750 Publication Model: Print Cited Medium: Internet

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Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens.

• Authors : Larsson P; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. .; Engqvist H

Subjects: Drug Resistance, Neoplasm* ; Inhibitory Concentration 50*; Drug Screening Assays, Antitumor/Drug Screening Assays, Antitumor/Drug Screening Assays, Antitumor/*standards

• Source: Scientific reports [Sci Rep] 2020 Apr 02; Vol. 10 (1), pp. 5798. Date of Electronic Publication: 2020 Apr 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Determination of Half-Maximal Inhibitory Concentration of an Enzyme Inhibitor.

• Authors : Georgakis N; Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.; Ioannou E

Subjects: Inhibitory Concentration 50*; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

• Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2089, pp. 41-46.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Computational Evaluation of Curcumenol as a Potential Inhibitor against Calcineurin Protein.

• Authors : R. M., Nivya¹ ; Joy, Amitha¹

Subjects: *INHIBITORY Concentration 50; *PHOSPHOPROTEIN phosphatases; *MOLECULAR dynamics

• Source: Current Trends in Biotechnology & Pharmacy. 2024 Supplement, Vol. 18, p67-76. 10p.

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