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Academic Journal

Enforced CARD11/MALT1 signaling in dendritic cells triggers hemophagocytic lymphohistiocytosis.

  • Authors : Isay SE; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University of Munich, Munich 81675, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich 81675, Germany.

Subjects: Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/metabolism ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/genetics ; Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/immunology

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Dec 17; Vol. 121 (51), pp. e2413162121. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Controlling the trans effect induced by nitric oxide and carbon monoxide: H93C myoglobin versus H-NOX sensors and soluble guanylate cyclase.

  • Authors : Yoo BK; Laboratoire d'Optique et Biosciences, INSERM U-1182, CNRS UMR 7645, Ecole Polytechnique, Palaiseau, France.; Lambry JC

Subjects: Carbon Monoxide*/Carbon Monoxide*/Carbon Monoxide*/metabolism ; Carbon Monoxide*/Carbon Monoxide*/Carbon Monoxide*/chemistry ; Nitric Oxide*/Nitric Oxide*/Nitric Oxide*/metabolism

  • Source: Protein science : a publication of the Protein Society [Protein Sci] 2024 Dec; Vol. 33 (12), pp. e5231.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet

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Academic Journal

Role of the NO-GC/cGMP signaling pathway in platelet biomechanics.

  • Authors : Balmes A; Institute of Applied Physics, University of Tübingen, Tübingen, Germany.; Rodríguez JG

Subjects: Blood Platelets*/Blood Platelets*/Blood Platelets*/metabolism ; Signal Transduction*; Humans

  • Source: Platelets [Platelets] 2024 Dec; Vol. 35 (1), pp. 2313359. Date of Electronic Publication: 2024 Feb 14.Publisher: Informa Healthcare Country of Publication: England NLM ID: 9208117 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Profiling CARD14 gene expression in Indian Psoriasis patients.

  • Authors : Singh S; ICMR-National Institute of Pathology, New Delhi, 110029, India.; Pradhan D

Subjects: Psoriasis*/Psoriasis*/Psoriasis*/genetics ; Psoriasis*/Psoriasis*/Psoriasis*/metabolism ; Psoriasis*/Psoriasis*/Psoriasis*/pathology

  • Source: Scientific reports [Sci Rep] 2024 Nov 20; Vol. 14 (1), pp. 28798. Date of Electronic Publication: 2024 Nov 20.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Supramolecular complexes of GCAP1: implications for inherited retinal dystrophies.

  • Authors : Biasi A; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134 Verona, Italy.; Marino V

Subjects: Guanylate Cyclase-Activating Proteins*/Guanylate Cyclase-Activating Proteins*/Guanylate Cyclase-Activating Proteins*/metabolism ; Guanylate Cyclase-Activating Proteins*/Guanylate Cyclase-Activating Proteins*/Guanylate Cyclase-Activating Proteins*/chemistry ; Guanylate Cyclase-Activating Proteins*/Guanylate Cyclase-Activating Proteins*/Guanylate Cyclase-Activating Proteins*/genetics

  • Source: International journal of biological macromolecules [Int J Biol Macromol] 2024 Nov; Vol. 279 (Pt 1), pp. 135068. Date of Electronic Publication: 2024 Aug 24.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Real-time imaging of cGMP signaling shows pronounced differences between glomerular endothelial cells and podocytes.

  • Authors : Rutkowski N; Department II Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cluster of Excellence Cellular Stress Responses in Aging- associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Subjects: Cyclic GMP*/Cyclic GMP*/Cyclic GMP*/metabolism ; Podocytes*/Podocytes*/Podocytes*/metabolism ; Endothelial Cells*/Endothelial Cells*/Endothelial Cells*/metabolism

  • Source: Scientific reports [Sci Rep] 2024 Oct 30; Vol. 14 (1), pp. 26099. Date of Electronic Publication: 2024 Oct 30.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Bioinformatic analysis of molecular characteristics and oncogenic features of CARD14 in human cancer.

  • Authors : Bespalov D; Immunology Unit, Department of Pathology and Experimental Therapy, School of Medicine, Universitat de Barcelona, Barcelona, 08007, Spain.; Immunity, Inflammation and Cancer Group, Oncobell Program, Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, 08907, Spain.

Subjects: CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/genetics ; CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/metabolism ; Neoplasms*/Neoplasms*/Neoplasms*/genetics

  • Source: Scientific reports [Sci Rep] 2024 Oct 03; Vol. 14 (1), pp. 22972. Date of Electronic Publication: 2024 Oct 03.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The influence of paraventricular nucleus of the hypothalamus soluble guanylate cyclase on autonomic and neuroendocrine responses to acute restraint stress in rats.

  • Authors : Busnardo C; Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.; Crestani CC

Subjects: Paraventricular Hypothalamic Nucleus*/Paraventricular Hypothalamic Nucleus*/Paraventricular Hypothalamic Nucleus*/drug effects ; Paraventricular Hypothalamic Nucleus*/Paraventricular Hypothalamic Nucleus*/Paraventricular Hypothalamic Nucleus*/metabolism ; Restraint, Physical*

  • Source: The European journal of neuroscience [Eur J Neurosci] 2024 Oct; Vol. 60 (8), pp. 5849-5860. Date of Electronic Publication: 2024 Sep 05.Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes.

  • Authors : Iliaki S; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium.

Subjects: Polo-Like Kinase 1* ; Proto-Oncogene Proteins*/Proto-Oncogene Proteins*/Proto-Oncogene Proteins*/metabolism ; Proto-Oncogene Proteins*/Proto-Oncogene Proteins*/Proto-Oncogene Proteins*/genetics

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Oct; Vol. 228, pp. 116316. Date of Electronic Publication: 2024 May 24.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Different sensitivities of porcine coronary arteries and veins to BAY 60-2770, a soluble guanylate cyclase activator.

  • Authors : Tawa M; Department of Pathological and Molecular Pharmacology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, 569-1094, Japan. Electronic address: .; Nakagawa K

Subjects: Coronary Vessels*/Coronary Vessels*/Coronary Vessels*/drug effects ; Hydrocarbons, Fluorinated*/Hydrocarbons, Fluorinated*/Hydrocarbons, Fluorinated*/pharmacology ; Soluble Guanylyl Cyclase*/Soluble Guanylyl Cyclase*/Soluble Guanylyl Cyclase*/metabolism

  • Source: Journal of pharmacological sciences [J Pharmacol Sci] 2025 Jan; Vol. 157 (1), pp. 1-7. Date of Electronic Publication: 2024 Nov 14.Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Transcriptome Profiling Associated with CARD11 Overexpression in Colorectal Cancer Implicates a Potential Role for Tumor Immune Microenvironment and Cancer Pathways Modulation via NF-κB.

  • Authors : Alhosani F; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.

Subjects: Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/genetics ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/pathology ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/immunology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 26; Vol. 25 (19). Date of Electronic Publication: 2024 Sep 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

NONO2P, a novel nitric oxide donor, causes vasorelaxation through NO/sGC/PKG pathway, K + channels opening and SERCA activation.

  • Authors : Moraes RA; Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.

Subjects: Vasodilation*/Vasodilation*/Vasodilation*/drug effects ; Nitric Oxide Donors*/Nitric Oxide Donors*/Nitric Oxide Donors*/pharmacology ; Rats, Wistar*

  • Source: European journal of pharmacology [Eur J Pharmacol] 2024 Sep 15; Vol. 979, pp. 176822. Date of Electronic Publication: 2024 Jul 22.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Allosteric Communication of the Dimerization and the Catalytic Domain in Photoreceptor Guanylate Cyclase.

  • Authors : Shahu MK; Department of Neuroscience, Carl von Ossietzky Universität Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg ,Germany.; Schuhmann F

Subjects: Guanylate Cyclase*/Guanylate Cyclase*/Guanylate Cyclase*/metabolism ; Guanylate Cyclase*/Guanylate Cyclase*/Guanylate Cyclase*/chemistry ; Guanylate Cyclase*/Guanylate Cyclase*/Guanylate Cyclase*/genetics

  • Source: Biochemistry [Biochemistry] 2024 Sep 03; Vol. 63 (17), pp. 2131-2140. Date of Electronic Publication: 2024 Aug 23.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Moonlighting Crypto-Enzymes and Domains as Ancient and Versatile Signaling Devices.

  • Authors : Turek I; Australian Centre for Disease Preparedness, Commonwealth Scientific and Industrial Research Organisation, East Geelong, VIC 3220, Australia.; Wong A

Subjects: Signal Transduction*; Adenylyl Cyclases/Adenylyl Cyclases/Adenylyl Cyclases/metabolism ; Adenylyl Cyclases/Adenylyl Cyclases/Adenylyl Cyclases/chemistry

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 02; Vol. 25 (17). Date of Electronic Publication: 2024 Sep 02.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease.

  • Authors : DeVore SB; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA

Subjects: CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/metabolism ; CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/genetics ; Proto-Oncogene Proteins c-myc*/Proto-Oncogene Proteins c-myc*/Proto-Oncogene Proteins c-myc*/metabolism

  • Source: Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114589. Date of Electronic Publication: 2024 Aug 06.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Efficacy of BAY 60-2770, a Soluble Guanylate Cyclase Activator, for Coronary Spasm in Animal Models.

  • Authors : Tawa M; Department of Pathological and Molecular Pharmacology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569-1094, Japan (M.T., K.N., M.O.) .; Nakagawa K

Subjects: Soluble Guanylyl Cyclase*/Soluble Guanylyl Cyclase*/Soluble Guanylyl Cyclase*/metabolism ; Coronary Vessels*/Coronary Vessels*/Coronary Vessels*/drug effects ; Benzoates*/Benzoates*/Benzoates*/pharmacology

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2024 Aug 19; Vol. 390 (3), pp. 280-287. Date of Electronic Publication: 2024 Aug 19.Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Electronic

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Academic Journal

Targeting IL-1 controls refractory pityriasis rubra pilaris.

  • Authors : Schmauch E; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Subjects: Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/drug therapy ; Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/pathology ; Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/genetics

  • Source: Science advances [Sci Adv] 2024 Jul 05; Vol. 10 (27), pp. eado2365. Date of Electronic Publication: 2024 Jul 03.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic

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Academic Journal

Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling: A Nonrandomized Trial.

  • Authors : Velasco RC; Department of Dermatology, Oregon Health & Science University, Portland.; Shao C

Subjects: Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/drug therapy ; Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/administration & dosage ; Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/pharmacology

  • Source: JAMA dermatology [JAMA Dermatol] 2024 Jun 01; Vol. 160 (6), pp. 641-645.Publisher: American Medical Association Country of Publication: United States NLM ID: 101589530 Publication Model: Print Cited Medium: Internet ISSN:

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Report

Successful treatment of CARD14-negative juvenile Pityriasis rubra pilaris with Ustekinumab.

Subjects: Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/Pityriasis Rubra Pilaris*/drug therapy ; Ustekinumab*/Ustekinumab*/Ustekinumab*/therapeutic use ; CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/CARD Signaling Adaptor Proteins*/genetics

  • Source: Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2024 Jun; Vol. 38 (6), pp. e512-e514. Date of Electronic Publication: 2023 DecPublisher: Wiley-Blackwell Country of Publication: England NLM ID: 9216037 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

NMR Structure of Retinal Guanylate Cyclase Activating Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances Cyclase Activation.

  • Authors : Cudia DL; Department of Chemistry, University of California, Davis, Davis, California 95616, United States.; Ahoulou EO

Subjects: Guanylate Cyclase*/Guanylate Cyclase*/Guanylate Cyclase*/genetics ; Guanylate Cyclase*/Guanylate Cyclase*/Guanylate Cyclase*/metabolism ; Guanylate Cyclase*/Guanylate Cyclase*/Guanylate Cyclase*/chemistry

  • Source: Biochemistry [Biochemistry] 2024 May 21; Vol. 63 (10), pp. 1246-1256. Date of Electronic Publication: 2024 Apr 25.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Structural insight into hormone recognition by the natriuretic peptide receptor-A.

  • Authors : Ogawa H; Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.; Kodama M

Subjects: Receptors, Atrial Natriuretic Factor*/Receptors, Atrial Natriuretic Factor*/Receptors, Atrial Natriuretic Factor*/metabolism ; Receptors, Atrial Natriuretic Factor*/Receptors, Atrial Natriuretic Factor*/Receptors, Atrial Natriuretic Factor*/chemistry ; Receptors, Atrial Natriuretic Factor*/Receptors, Atrial Natriuretic Factor*/Receptors, Atrial Natriuretic Factor*/genetics

  • Source: The FEBS journal [FEBS J] 2024 May; Vol. 291 (10), pp. 2273-2286. Date of Electronic Publication: 2024 Mar 04.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Academic Journal

A 2-week treatment with 5-azacytidine improved the hypercontractility state in prostate from obese mice: Role of the nitric oxide-cyclic guanosine monophosphate signalling pathway.

  • Authors : Ghezzi AC; Department of Translation Medicine (Pharmacology area), Faculty of Medical Sciences, University of Campinas (Unicamp), Campinas, Brazil.; Passos GR

Subjects: Nitric Oxide*/Nitric Oxide*/Nitric Oxide*/metabolism ; Prostatic Hyperplasia*/Prostatic Hyperplasia*/Prostatic Hyperplasia*/metabolism; Male

  • Source: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2024 Apr; Vol. 51 (4), pp. e13851.Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0425076 Publication Model: Print Cited Medium: Internet ISSN: 1440-1681

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Academic Journal

The nitric oxide-soluble guanylate cyclase-cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase.

  • Authors : Benza RL; Icahn School of Medicine at Mount Sinai, New York, NY, USA .; Grünig E

Subjects: Hypertension, Pulmonary*/Hypertension, Pulmonary*/Hypertension, Pulmonary*/etiology ; Pulmonary Arterial Hypertension*; Humans

  • Source: European respiratory review : an official journal of the European Respiratory Society [Eur Respir Rev] 2024 Mar 20; Vol. 33 (171). Date of Electronic Publication: 2024 Mar 20 Publisher: European Respiratory Society Country of Publication: England NLM ID: 9111391 Publication Model: Electronic-Print Cited Medium: Internet

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Academic Journal

Development and characterization of a Gucy2d-cre mouse to selectively manipulate a subset of inhibitory spinal dorsal horn interneurons.

  • Authors : Serafin EK; Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, OH, USA.; Yoo JJ

Subjects: Dynorphins* ; Spinal Cord Dorsal Horn* ; Red Fluorescent Protein*

  • Source: PloS one [PLoS One] 2024 Mar 14; Vol. 19 (3), pp. e0300282. Date of Electronic Publication: 2024 Mar 14 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Identification of new multi-substituted 1H-pyrazolo[3,4-c]pyridin-7(6H)-ones as soluble guanylyl cyclase (sGC) stimulators with vasoprotective and anti-inflammatory activities.

  • Authors : Kintos DP; Laboratory of Medicinal Chemistry, Department of Pharmacy, University of Patras, Patras, GR-26500, Greece.; Salagiannis K

Subjects: Endothelial Cells*/Endothelial Cells*/Endothelial Cells*/metabolism ; Guanylate Cyclase*/Guanylate Cyclase*/Guanylate Cyclase*/metabolism; Humans

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Mar; Vol. 144, pp. 107170. Date of Electronic Publication: 2024 Feb 02.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-25 of  4,779 results for ""Guanylate Cyclase metabolism""