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Academic Journal

Discovery of novel 2,4-diarylaminopyrimidine hydrazone derivatives as potent anti-thyroid cancer agents capable of inhibiting FAK.

  • Authors : Li H; Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.; Jia MQ

Subjects: Hydrazones*/Hydrazones*/Hydrazones*/pharmacology ; Hydrazones*/Hydrazones*/Hydrazones*/chemistry ; Hydrazones*/Hydrazones*/Hydrazones*/chemical synthesis

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2423875. Date of Electronic Publication: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Histone deacetylase upregulation of neuropilin-1 in osteosarcoma is essential for pulmonary metastasis.

  • Authors : Nerlakanti N; Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL, 33612, USA; Department of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.

Subjects: Neuropilin-1*/Neuropilin-1*/Neuropilin-1*/genetics ; Neuropilin-1*/Neuropilin-1*/Neuropilin-1*/metabolism ; Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/pathology

  • Source: Cancer letters [Cancer Lett] 2024 Dec 01; Vol. 606, pp. 217302. Date of Electronic Publication: 2024 Oct 18.Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

ADAR1 Promotes Invasion and Migration and Inhibits Ferroptosis via the FAK/AKT Pathway in Colorectal Cancer.

  • Authors : He D; Cancer Center, First Hospital of Jilin University, Changchun, Jilin, China.; Niu C

Subjects: Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/pathology ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/genetics ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/metabolism

  • Source: Molecular carcinogenesis [Mol Carcinog] 2024 Dec; Vol. 63 (12), pp. 2401-2413. Date of Electronic Publication: 2024 Sep 06.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Defactinib inhibits FAK phosphorylation and regulates psoriasis via attenuating hyperproliferation of keratinocytes.

  • Authors : Zuo Y; Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, Hubei, China.; Hubei Province & Key Laboratory of Skin Infection and Immunity, Wuhan, Hubei, China.

Subjects: Psoriasis*/Psoriasis*/Psoriasis*/pathology ; Psoriasis*/Psoriasis*/Psoriasis*/drug therapy ; Psoriasis*/Psoriasis*/Psoriasis*/chemically induced

  • Source: The Journal of dermatology [J Dermatol] 2024 Dec; Vol. 51 (12), pp. 1596-1606. Date of Electronic Publication: 2024 Jul 25.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7600545 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Spatial organization of PI3K-PI(3,4,5)P 3 -AKT signaling by focal adhesions.

  • Authors : Wang J; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Subjects: Focal Adhesions*/Focal Adhesions*/Focal Adhesions*/metabolism ; Focal Adhesions*/Focal Adhesions*/Focal Adhesions*/genetics ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism

  • Source: Molecular cell [Mol Cell] 2024 Nov 21; Vol. 84 (22), pp. 4401-4418.e9. Date of Electronic Publication: 2024 Nov 01.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Targeting DUSP26 to drive cardiac mitochondrial dynamics via FAK-ERK signaling in diabetic cardiomyopathy.

  • Authors : Liu C; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province, NO. 246, Xuefu Road, Nangang District, Harbin, 150086, China

Subjects: Diabetic Cardiomyopathies*/Diabetic Cardiomyopathies*/Diabetic Cardiomyopathies*/metabolism ; Diabetic Cardiomyopathies*/Diabetic Cardiomyopathies*/Diabetic Cardiomyopathies*/pathology ; Diabetic Cardiomyopathies*/Diabetic Cardiomyopathies*/Diabetic Cardiomyopathies*/genetics

  • Source: Free radical biology & medicine [Free Radic Biol Med] 2024 Nov 20; Vol. 225, pp. 856-870. Date of Electronic Publication: 2024 Nov 05.Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression.

  • Authors : Xu Z; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.; Zhou Y

Subjects: Carcinoma, Pancreatic Ductal*/Carcinoma, Pancreatic Ductal*/Carcinoma, Pancreatic Ductal*/pathology ; Carcinoma, Pancreatic Ductal*/Carcinoma, Pancreatic Ductal*/Carcinoma, Pancreatic Ductal*/metabolism ; Carcinoma, Pancreatic Ductal*/Carcinoma, Pancreatic Ductal*/Carcinoma, Pancreatic Ductal*/genetics

  • Source: Cancer research [Cancer Res] 2024 Nov 04; Vol. 84 (21), pp. 3602-3616.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium:

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Academic Journal

NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-κB signaling pathway.

  • Authors : Liu W; Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang City, 421001, Hunan Province, China.; Luo G

Subjects: Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/metabolism ; Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/genetics ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/pathology

  • Source: Neoplasia (New York, N.Y.) [Neoplasia] 2024 Nov; Vol. 57, pp. 101059. Date of Electronic Publication: 2024 Sep 25.Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Ankrd1 inhibits the FAK/Rho-GTPase/F-actin pathway by downregulating ITGA6 transcriptional to regulate myoblast functions.

  • Authors : Huang C; Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education, Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.; Zhong Q

Subjects: Cell Differentiation*/Cell Differentiation*/Cell Differentiation*/genetics ; Signal Transduction* ; Cell Proliferation*/Cell Proliferation*/Cell Proliferation*/genetics

  • Source: Journal of cellular physiology [J Cell Physiol] 2024 Nov; Vol. 239 (11), pp. e31359. Date of Electronic Publication: 2024 Jul 10.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A novel selective FAK inhibitor E2 inhibits ovarian cancer metastasis and growth by inducing cytotoxic autophagy.

  • Authors : Feng Z; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.; Wei W

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; Focal Adhesion Kinase 1*/Focal Adhesion Kinase 1*/Focal Adhesion Kinase 1*/antagonists & inhibitors

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Nov; Vol. 229, pp. 116461. Date of Electronic Publication: 2024 Aug 03.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  4,856 results for ""Focal Adhesion Kinase 1""