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Academic Journal

Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases.

  • Authors : Lin F; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.; Mabanglo MF

Subjects: Phosphines*/Phosphines*/Phosphines*/chemistry ; Phosphines*/Phosphines*/Phosphines*/pharmacology ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/metabolism

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 15131-15147. Date of Electronic Publication: 2024 Sep 02.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

The Effect of the Lysine Acetylation Modification of ClpP on the Virulence of Vibrio alginolyticus .

  • Authors : Wang S; Fisheries College, Guangdong Ocean University, Zhanjiang 524025, China.; Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang 524025, China.

Subjects: Vibrio alginolyticus*/Vibrio alginolyticus*/Vibrio alginolyticus*/pathogenicity ; Vibrio alginolyticus*/Vibrio alginolyticus*/Vibrio alginolyticus*/genetics ; Vibrio alginolyticus*/Vibrio alginolyticus*/Vibrio alginolyticus*/metabolism

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Sep 09; Vol. 29 (17). Date of Electronic Publication: 2024 Sep 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Multi-pass, single-molecule nanopore reading of long protein strands.

  • Authors : Motone K; Paul. G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA.; Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Japan.

Subjects: Nanopores* ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/chemistry ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/metabolism

  • Source: Nature [Nature] 2024 Sep; Vol. 633 (8030), pp. 662-669. Date of Electronic Publication: 2024 Sep 11.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells.

  • Authors : Cao J; Xiamen Key Laboratory of Translational Medical of Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361004, PR China; Department of Thyroid Head and Neck Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314099, PR China.

Subjects: Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/pathology ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/metabolism ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/drug therapy

  • Source: Neoplasia (New York, N.Y.) [Neoplasia] 2024 Sep; Vol. 55, pp. 101015. Date of Electronic Publication: 2024 Jun 29.Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Role of a substrate binding pocket in the amino terminal domain of Mycobacterium tuberculosis caseinolytic protease B (ClpB) in its function.

  • Authors : Singh D; Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.; Tripathi P

Subjects: Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/enzymology ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/metabolism ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/chemistry

  • Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Aug; Vol. 42 (12), pp. 6189-6199. Date of Electronic Publication: 2023 Jul 07.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism.

  • Authors : Paredes F; Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, United States.; Williams HC

Subjects: Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/metabolism ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/genetics ; Mitochondria*/Mitochondria*/Mitochondria*/metabolism

  • Source: Redox biology [Redox Biol] 2024 Jul; Vol. 73, pp. 103203. Date of Electronic Publication: 2024 May 21.Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Protein degradation by a component of the chaperonin-linked protease ClpP.

  • Authors : Ishikawa F; Faculty of Pharmacy, Kindai University, Osaka, Japan.; Homma M

Subjects: Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/metabolism ; Proteolysis*; Proteasome Endopeptidase Complex/Proteasome Endopeptidase Complex/Proteasome Endopeptidase Complex/metabolism

  • Source: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2024 Sep; Vol. 29 (9), pp. 695-709. Date of Electronic Publication: 2024 Jul 04.Publisher: Blackwell Science Ltd Country of Publication: England NLM ID: 9607379 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Proteolytic Regulation in the Biosynthesis of Natural Product Via a ClpP Protease System.

  • Authors : Ishikawa F; Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.; Uchida C

Subjects: Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/metabolism ; Proteolysis* ; Biological Products*/Biological Products*/Biological Products*/metabolism

  • Source: ACS chemical biology [ACS Chem Biol] 2024 Aug 16; Vol. 19 (8), pp. 1794-1802. Date of Electronic Publication: 2024 Aug 03.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Knockout Mouse Studies Show That Mitochondrial CLPP Peptidase and CLPX Unfoldase Act in Matrix Condensates near IMM, as Fast Stress Response in Protein Assemblies for Transcript Processing, Translation, and Heme Production.

  • Authors : Key J; Experimental Neurology, Clinic of Neurology, University Hospital, Goethe University Frankfurt, Heinrich Hoffmann Str. 7, 60590 Frankfurt am Main, Germany.; Gispert S

Subjects: Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/metabolism ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/genetics ; Mitochondria*/Mitochondria*/Mitochondria*/metabolism

  • Source: Genes [Genes (Basel)] 2024 May 27; Vol. 15 (6). Date of Electronic Publication: 2024 May 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425

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Academic Journal

A review of current therapeutics targeting the mitochondrial protease ClpP in diffuse midline glioma, H3 K27-altered.

  • Authors : Jackson ER; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales , Australia.

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/therapeutic use ; Brain Neoplasms*/Brain Neoplasms*/Brain Neoplasms*/drug therapy ; Brain Neoplasms*/Brain Neoplasms*/Brain Neoplasms*/pathology

  • Source: Neuro-oncology [Neuro Oncol] 2024 May 03; Vol. 26 (Supplement_2), pp. S136-S154.Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  1,646 results for ""Endopeptidase Clp""