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Academic Journal

Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders.

  • Authors : Hogg EKJ; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, UK.; Findlay GM

Subjects: Dyrk Kinases* ; Intellectual Disability* ; Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/genetics

  • Source: FEBS letters [FEBS Lett] 2023 Oct; Vol. 597 (19), pp. 2375-2415. Date of Electronic Publication: 2023 Sep 04.Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.

  • Authors : Henderson SH; Sussex Drug Discovery Centre, University of Sussex, Brighton, BN1 9RH, UK. Electronic address: .; Sorrell FJ

Subjects: Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/drug therapy ; Pyridazines*/Pyridazines*/Pyridazines*/chemistry; Iohexol/Iohexol/Iohexol/*analogs & derivatives

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Apr 05; Vol. 269, pp. 116292. Date of Electronic Publication: 2024 Mar 07.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors.

  • Authors : Karakose E; Diabetes, Obesity, Metabolism Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .; Wang X

Subjects: Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/metabolism ; Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/drug effects ; Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/cytology

  • Source: Cell reports. Medicine [Cell Rep Med] 2024 Dec 17; Vol. 5 (12), pp. 101832. Date of Electronic Publication: 2024 Dec 02.Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

[Research progress on the cognitive deficit of Down syndrome patients].

  • Authors : Shi W; Henan Provincial Key Laboratory of Genetic Diseases and Functional Genomics, Medical Genetics Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China. .; Liao S

Subjects: Down Syndrome*/Down Syndrome*/Down Syndrome*/genetics ; Down Syndrome*/Down Syndrome*/Down Syndrome*/complications ; Down Syndrome*/Down Syndrome*/Down Syndrome*/psychology

  • Source: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2024 Dec 10; Vol. 41 (12), pp. 1503-1507.Publisher: Sichuan University Country of Publication: China NLM ID: 9425197 Publication Model: Print Cited Medium: Print ISSN: 1003-9406 (Print)

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Academic Journal

DYRK2 controls GSTPI expression through ubiquitination and degradation of Twist1 to reduce chemotherapy resistance caused by EMT in breast cancer.

  • Authors : Xu G; The Comprehensive Cancer Center, Chongqing University Fuling Hospital, No.2 Gaosuntang Road, Fuling District, 408000, Chongqing, P.R. China.; Zhou M

Subjects: Twist-Related Protein 1*/Twist-Related Protein 1*/Twist-Related Protein 1*/metabolism ; Twist-Related Protein 1*/Twist-Related Protein 1*/Twist-Related Protein 1*/genetics ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/metabolism

  • Source: Journal of molecular histology [J Mol Histol] 2024 Dec 06; Vol. 56 (1), pp. 35. Date of Electronic Publication: 2024 Dec 06.Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Discovery of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors using an artificial intelligence model and their effects on tau and tubulin dynamics.

  • Authors : Chen JH; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Tu HJ

Subjects: Dyrk Kinases* ; Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/antagonists & inhibitors ; Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/metabolism

  • Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Dec; Vol. 181, pp. 117688. Date of Electronic Publication: 2024 Nov 25.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation.

  • Authors : Tu HJ; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Chao MW

Subjects: Dyrk Kinases* ; Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/antagonists & inhibitors ; Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/metabolism

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2418470. Date of Electronic Publication: 2024 Nov 04.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Identification, biological evaluation, and crystallographic analysis of coumestrol as a novel dual-specificity tyrosine-phosphorylation-regulated kinase 1A inhibitor.

  • Authors : Peng CH; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan.; Hwang TL

Subjects: Dyrk Kinases* ; Coumestrol*/Coumestrol*/Coumestrol*/pharmacology ; Coumestrol*/Coumestrol*/Coumestrol*/chemistry

  • Source: International journal of biological macromolecules [Int J Biol Macromol] 2024 Dec; Vol. 282 (Pt 4), pp. 136860. Date of Electronic Publication: 2024 Oct 29.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Analysis of 1386 epileptogenic brain lesions reveals association with DYRK1A and EGFR.

  • Authors : Boßelmann CM; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Subjects: ErbB Receptors*/ErbB Receptors*/ErbB Receptors*/genetics ; ErbB Receptors*/ErbB Receptors*/ErbB Receptors*/metabolism ; Dyrk Kinases*

  • Source: Nature communications [Nat Commun] 2024 Nov 30; Vol. 15 (1), pp. 10429. Date of Electronic Publication: 2024 Nov 30.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

A review on synthetic inhibitors of dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A) for the treatment of Alzheimer's disease (AD).

  • Authors : Gehlot P; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad 382481, Gujarat, India.; Pathak R

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Dyrk Kinases*

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Nov 01; Vol. 113, pp. 117925. Date of Electronic Publication: 2024 Sep 14.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  1,102 results for ""Dyrk Kinases""