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Academic Journal

Machine Learning-Based In Silico Prediction of the Inhibitory Activity of Chemical Substances Against Rat and Human Cytochrome P450s.

  • Authors : Ambe K; Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 4678603, Japan.; Nakamori M

Subjects: Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/chemistry ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology

  • Source: Chemical research in toxicology [Chem Res Toxicol] 2024 Nov 18; Vol. 37 (11), pp. 1843-1850. Date of Electronic Publication: 2024 Oct 20.Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

An In Silico-Guided Approach for Assessing Herb-Drug Interaction Potential: A Case Study with Cudrania tricuspidata Leaf Extracts.

  • Authors : Seo JI; Pharmacomicrobiomics Research Center and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-Do, Republic of Korea.; Kwak YB

Subjects: Computer Simulation* ; Herb-Drug Interactions* ; Moraceae*

  • Source: Planta medica [Planta Med] 2024 Sep; Vol. 90 (11), pp. 858-863. Date of Electronic Publication: 2024 Jul 09.Publisher: George Thieme Country of Publication: Germany NLM ID: 0066751 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Investigation of cytochrome P450 inhibitory properties of deoxyshikonin, a bioactive compound from Lithospermum erythrorhizon Sieb. et Zucc.

  • Authors : Zhang Y; Changning Maternity and Infant Health Hospital and School of Life Sciences, Shanghai Key Laboratory of Regulatory Biology, East China Normal University, Shanghai, People's Republic of China.; Gao J

Subjects: Lithospermum*/Lithospermum*/Lithospermum*/chemistry ; Microsomes, Liver*/Microsomes, Liver*/Microsomes, Liver*/drug effects ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology

  • Source: Phytotherapy research : PTR [Phytother Res] 2024 Oct; Vol. 38 (10), pp. 4855-4864. Date of Electronic Publication: 2022 Nov 01.Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1573

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Academic Journal

Inhibitory Effect of Two Carbonic Anhydrases Inhibitors on the Activity of Major Cytochrome P450 Enzymes.

  • Authors : Elbarbry FA; School of Pharmacy, Pacific University, 222 SE 8th Ave., Hillsboro, OR, 97123, USA. .; Ibrahim TM

Subjects: Carbonic Anhydrase Inhibitors*/Carbonic Anhydrase Inhibitors*/Carbonic Anhydrase Inhibitors*/pharmacology ; Carbonic Anhydrase Inhibitors*/Carbonic Anhydrase Inhibitors*/Carbonic Anhydrase Inhibitors*/chemistry ; Coumarins*/Coumarins*/Coumarins*/pharmacology

  • Source: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2024 Sep; Vol. 49 (5), pp. 583-594. Date of Electronic Publication: 2024 Jun 24.Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy.

  • Authors : Tan BH; Division of Applied Biomedical Sciences and Biotechnology, International Medical University, Kuala Lumpur, Malaysia.; Ahemad N

Subjects: Drug Interactions* ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology

  • Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2024 Sep; Vol. 54 (9), pp. 575-598. Date of Electronic Publication: 2024 Aug 28.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Identification of the human Cytochrome P450 enzymes (P450s) responsible for metabolizing infigratinib to its pharmacologically active Metabolites, BHS697, and CQM157, and assessment of their in vitro inhibition of P450s and UDP-glucuronosyltransferases (UGTs).

  • Authors : Liu S; Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: .; Zhao S

Subjects: Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/metabolism

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Aug; Vol. 226, pp. 116390. Date of Electronic Publication: 2024 Jun 22.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Harnessing machine learning to predict cytochrome P450 inhibition through molecular properties.

  • Authors : Zahid H; Department of Electronics and Information Engineering, Jeonbuk National University, Jeonju, 54896, South Korea.; Tayara H

Subjects: Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism ; Machine Learning*

  • Source: Archives of toxicology [Arch Toxicol] 2024 Aug; Vol. 98 (8), pp. 2647-2658. Date of Electronic Publication: 2024 Apr 15.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury.

  • Authors : Kaito S; School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.; Takeshita JI

Subjects: Chemical and Drug Induced Liver Injury* ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism

  • Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2024 Jul; Vol. 54 (7), pp. 411-419. Date of Electronic Publication: 2024 Aug 21.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Mass spectrometric methods for evaluation of voriconazole avian pharmacokinetics and the inhibition of its cytochrome P450-induced metabolism.

  • Authors : Lehner AF; Section of Toxicology, Michigan State University Veterinary Diagnostic Laboratory, Michigan State University, East Lansing, MI, USA.; Johnson SD

Subjects: Voriconazole*/Voriconazole*/Voriconazole*/pharmacokinetics ; Antifungal Agents*/Antifungal Agents*/Antifungal Agents*/pharmacokinetics ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology

  • Source: Toxicology mechanisms and methods [Toxicol Mech Methods] 2024 Jul; Vol. 34 (6), pp. 654-668. Date of Electronic Publication: 2024 Feb 29.Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Impact of Inorganic Systems and Photoactive Metal Compounds on Cytochrome P450 Enzymes and Metabolism: From Induction to Inhibition.

  • Authors : Havrylyuk D; Department of Chemistry, North Carolina State University, Raleigh, NC 27067, USA.; Heidary DK

Subjects: Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/chemistry

  • Source: Biomolecules [Biomolecules] 2024 Apr 04; Vol. 14 (4). Date of Electronic Publication: 2024 Apr 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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  • 1-10 of  6,089 results for ""Cytochrome P-450 Enzyme Inhibitors""