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  • 1-10 of  965 results for ""Cyclic Nucleotide Phosphodiesterases, Type 3""

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Academic Journal

First-in-Human Dose-Escalation Study of the First-in-Class PDE3A-SLFN12 Complex Inducer BAY 2666605 in Patients with Advanced Solid Tumors Coexpressing SLFN12 and PDE3A.

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Neoplasms*/Neoplasms*/Neoplasms*/pathology ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism

  • Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Dec 16; Vol. 30 (24), pp. 5568-5576.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium:

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Academic Journal

Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.

  • Authors : Krause PN; Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.; McGeorge G

Subjects: Cell Proliferation* ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/genetics

  • Source: Physiological reports [Physiol Rep] 2024 Oct; Vol. 12 (20), pp. e70089.Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM

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Academic Journal

Novel mechanism of cyclic nucleotide crosstalk mediated by PKG-dependent proteasomal degradation of the Hsp90 client protein phosphodiesterase 3A.

  • Authors : Zemskov EA; Center for Translational Science, Florida International University, Port St Lucie, Florida, USA; Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Oct; Vol. 300 (10), pp. 107723. Date of Electronic Publication: 2024 Aug 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation.

  • Authors : Jiao X; Organ Transplantation Center, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.; Li Y

Subjects: Autophagy*/Autophagy*/Autophagy*/drug effects ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism ; Cyclic AMP*/Cyclic AMP*/Cyclic AMP*/metabolism

  • Source: Science translational medicine [Sci Transl Med] 2024 Nov 27; Vol. 16 (775), pp. eadk0636. Date of Electronic Publication: 2024 Nov 27.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic

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Academic Journal

A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors.

  • Authors : Takaki EO; Department of Medical Innovations, Osaka Research Center for Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Minoh, Japan.; Kiyono K

Subjects: Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/drug therapy ; Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/genetics ; Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/pathology

  • Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Aug 15; Vol. 30 (16), pp. 3603-3621.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium:

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Academic Journal

PDE3B regulates KRT6B and increases the sensitivity of bladder cancer cells to copper ionophores.

  • Authors : Feng Y; Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.; Huang Z

Subjects: Copper*/Copper*/Copper*/metabolism ; Copper*/Copper*/Copper*/pharmacology ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism

  • Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Jul; Vol. 397 (7), pp. 4911-4925. Date of Electronic Publication: 2024 Jan 02.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner.

  • Authors : Khalil JS; Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.; Law R

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/genetics ; Blood Platelets*/Blood Platelets*/Blood Platelets*/metabolism

  • Source: Cells [Cells] 2024 Jun 26; Vol. 13 (13). Date of Electronic Publication: 2024 Jun 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Administration of Liposomal-Based Pde3b Gene Therapy Protects Mice Against Collagen-Induced Rheumatoid Arthritis via Modulating Macrophage Polarization.

  • Authors : Chen L; Department of Rheumatology and Immunology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Zhou Q

Subjects: Arthritis, Experimental*/Arthritis, Experimental*/Arthritis, Experimental*/genetics ; Arthritis, Experimental*/Arthritis, Experimental*/Arthritis, Experimental*/prevention & control ; Arthritis, Experimental*/Arthritis, Experimental*/Arthritis, Experimental*/therapy

  • Source: International journal of nanomedicine [Int J Nanomedicine] 2024 May 17; Vol. 19, pp. 4411-4427. Date of Electronic Publication: 2024 May 17 (Print Publication: 2024).Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Personal Genetic-Hypertension Odyssey From Phenotypes to Genotypes and Targets.

  • Authors : Luft FC; Experimental and Clinical Research Center, a cooperation between the Max-Delbrück Center for Molecular Medicine and the Charité Medical Faculty, Berlin, Germany.

Subjects: Phenotype* ; Hypertension*/Hypertension*/Hypertension*/genetics; Humans

  • Source: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Dec; Vol. 81 (12), pp. 2395-2406. Date of Electronic Publication: 2024 Oct 02.Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Dual Inhibition of Phosphodiesterase 3 and 4 Enzymes by Ensifentrine Protects against MRSA-Induced Lung Endothelial and Epithelial Dysfunction.

  • Authors : Al Matni MY; Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois Chicago, Chicago, IL 60612, USA.; Meliton L

Subjects: Methicillin-Resistant Staphylococcus aureus*/Methicillin-Resistant Staphylococcus aureus*/Methicillin-Resistant Staphylococcus aureus*/drug effects ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/pharmacology ; Endothelial Cells*/Endothelial Cells*/Endothelial Cells*/drug effects

  • Source: Cells [Cells] 2024 Oct 23; Vol. 13 (21). Date of Electronic Publication: 2024 Oct 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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  • 1-10 of  965 results for ""Cyclic Nucleotide Phosphodiesterases, Type 3""