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Academic Journal

First-in-Human Dose-Escalation Study of the First-in-Class PDE3A-SLFN12 Complex Inducer BAY 2666605 in Patients with Advanced Solid Tumors Coexpressing SLFN12 and PDE3A.

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Neoplasms*/Neoplasms*/Neoplasms*/pathology ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism

  • Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Dec 16; Vol. 30 (24), pp. 5568-5576.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium:

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Academic Journal

Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.

  • Authors : Krause PN; Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.; McGeorge G

Subjects: Cell Proliferation* ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/genetics

  • Source: Physiological reports [Physiol Rep] 2024 Oct; Vol. 12 (20), pp. e70089.Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM

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Academic Journal

Novel mechanism of cyclic nucleotide crosstalk mediated by PKG-dependent proteasomal degradation of the Hsp90 client protein phosphodiesterase 3A.

  • Authors : Zemskov EA; Center for Translational Science, Florida International University, Port St Lucie, Florida, USA; Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Oct; Vol. 300 (10), pp. 107723. Date of Electronic Publication: 2024 Aug 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation.

  • Authors : Jiao X; Organ Transplantation Center, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.; Li Y

Subjects: Autophagy*/Autophagy*/Autophagy*/drug effects ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism ; Cyclic AMP*/Cyclic AMP*/Cyclic AMP*/metabolism

  • Source: Science translational medicine [Sci Transl Med] 2024 Nov 27; Vol. 16 (775), pp. eadk0636. Date of Electronic Publication: 2024 Nov 27.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic

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Academic Journal

A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors.

  • Authors : Takaki EO; Department of Medical Innovations, Osaka Research Center for Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Minoh, Japan.; Kiyono K

Subjects: Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/drug therapy ; Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/genetics ; Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/Gastrointestinal Stromal Tumors*/pathology

  • Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Aug 15; Vol. 30 (16), pp. 3603-3621.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium:

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Academic Journal

PDE3B regulates KRT6B and increases the sensitivity of bladder cancer cells to copper ionophores.

  • Authors : Feng Y; Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.; Huang Z

Subjects: Copper*/Copper*/Copper*/metabolism ; Copper*/Copper*/Copper*/pharmacology ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism

  • Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Jul; Vol. 397 (7), pp. 4911-4925. Date of Electronic Publication: 2024 Jan 02.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner.

  • Authors : Khalil JS; Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.; Law R

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/genetics ; Blood Platelets*/Blood Platelets*/Blood Platelets*/metabolism

  • Source: Cells [Cells] 2024 Jun 26; Vol. 13 (13). Date of Electronic Publication: 2024 Jun 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Administration of Liposomal-Based Pde3b Gene Therapy Protects Mice Against Collagen-Induced Rheumatoid Arthritis via Modulating Macrophage Polarization.

  • Authors : Chen L; Department of Rheumatology and Immunology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Zhou Q

Subjects: Arthritis, Experimental*/Arthritis, Experimental*/Arthritis, Experimental*/genetics ; Arthritis, Experimental*/Arthritis, Experimental*/Arthritis, Experimental*/prevention & control ; Arthritis, Experimental*/Arthritis, Experimental*/Arthritis, Experimental*/therapy

  • Source: International journal of nanomedicine [Int J Nanomedicine] 2024 May 17; Vol. 19, pp. 4411-4427. Date of Electronic Publication: 2024 May 17 (Print Publication: 2024).Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.

  • Authors : Skogestad J; Institute for Experimental Medical Research (J.S., I.A., K.H., M.L., O.S.E., I.V., M.B., S.M., X.S., W.E.L., P.K.L., I.S., C.R.C., J.M.A.), Oslo University Hospital and University of Oslo, Norway.; Albert I

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism ; Heart Failure*/Heart Failure*/Heart Failure*/metabolism

  • Source: Circulation [Circulation] 2023 Apr 18; Vol. 147 (16), pp. 1221-1236. Date of Electronic Publication: 2023 Mar 06.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms.

  • Authors : Skryabin EB; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; De Jong KA

Subjects: CRISPR-Cas Systems*/CRISPR-Cas Systems*/CRISPR-Cas Systems*/genetics ; Myocytes, Cardiac*/Myocytes, Cardiac*/Myocytes, Cardiac*/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 2*/Cyclic Nucleotide Phosphodiesterases, Type 2*/Cyclic Nucleotide Phosphodiesterases, Type 2*/metabolism

  • Source: Cells [Cells] 2023 Jun 04; Vol. 12 (11). Date of Electronic Publication: 2023 Jun 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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  • 1-10 of  971 results for ""Cyclic Nucleotide Phosphodiesterases, Type 3""