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  • 1-10 of  524 results for ""Cyclic Nucleotide Phosphodiesterases, Type 1""

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Academic Journal

Discovery of Selective PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects by Targeting the Metal Pocket.

  • Authors : Jiang MY; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.; Zhang C

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/antagonists & inhibitors ; Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/metabolism ; Phosphodiesterase Inhibitors*/Phosphodiesterase Inhibitors*/Phosphodiesterase Inhibitors*/pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Nov 28; Vol. 67 (22), pp. 20203-20213. Date of Electronic Publication: 2024 Nov 15.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Ca 2+ -dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses.

  • Authors : Zhai S; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Otsuka S

Subjects: Synapses*/Synapses*/Synapses*/metabolism ; Neuronal Plasticity*/Neuronal Plasticity*/Neuronal Plasticity*/physiology ; Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/metabolism

  • Source: Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114540. Date of Electronic Publication: 2024 Jul 25.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

PDE1B, a potential biomarker associated with tumor microenvironment and clinical prognostic significance in osteosarcoma.

  • Authors : Chen Q; Department of Hand Surgery, Affiliated Hospital and Medical School of Nantong University, No.20 West Temple Road, Nantong, 226001, Jiangsu Province, China.; Xing C

Subjects: Biomarkers, Tumor*/Biomarkers, Tumor*/Biomarkers, Tumor*/genetics ; Biomarkers, Tumor*/Biomarkers, Tumor*/Biomarkers, Tumor*/metabolism ; Bone Neoplasms*/Bone Neoplasms*/Bone Neoplasms*/genetics

  • Source: Scientific reports [Sci Rep] 2024 Jun 14; Vol. 14 (1), pp. 13790. Date of Electronic Publication: 2024 Jun 14.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Circuit-Wide Gene Network Analysis Reveals Sex-Specific Roles for Phosphodiesterase 1b in Cocaine Addiction.

  • Authors : Teague CD; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.; Markovic T

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/metabolism ; Cocaine-Related Disorders*/Cocaine-Related Disorders*/Cocaine-Related Disorders*/genetics

  • Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Jun 05; Vol. 44 (23). Date of Electronic Publication: 2024 Jun 05.Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Design, Synthesis, and Evaluation of Dihydropyrimidine Derivatives as Selective PDE1 Inhibitors for the Treatment of Liver Fibrosis.

  • Authors : Zhao ZJ; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China.; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China.

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/antagonists & inhibitors ; Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/metabolism ; Drug Design*

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 May 23; Vol. 67 (10), pp. 8309-8322. Date of Electronic Publication: 2024 Apr 26.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights.

  • Authors : Alam A; Department of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Pakistan.; Gul S

Subjects: Molecular Docking Simulation* ; Acetophenones*/Acetophenones*/Acetophenones*/chemistry ; Acetophenones*/Acetophenones*/Acetophenones*/pharmacology

  • Source: Future medicinal chemistry [Future Med Chem] 2024; Vol. 16 (12), pp. 1185-1203. Date of Electronic Publication: 2024 May 22.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.

Subjects: Coronary Disease*/Coronary Disease*/Coronary Disease*/genetics ; Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/complications ; Myocardial Infarction*/Myocardial Infarction*/Myocardial Infarction*/complications

  • Source: Diabetes care [Diabetes Care] 2023 Jun 01; Vol. 46 (6), pp. 1271-1281.Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C.

  • Authors : Sun W; Center for Basic Medical Research & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300457, China.; The Institute of Cardiovascular Diseases, Tianjin University, Tianjin 300457, China.

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/metabolism ; Endoplasmic Reticulum Stress*/Endoplasmic Reticulum Stress*/Endoplasmic Reticulum Stress*/drug effects ; Homocysteine*/Homocysteine*/Homocysteine*/pharmacology

  • Source: Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2022 Mar 25; Vol. 54 (3), pp. 388-399.Publisher: China Science Publishing & Media Ltd Country of Publication: China NLM ID: 101206716 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals.

  • Authors : Golshiri K; Dept. of Internal Medicine (K.G., E.A.A., E.R.-B., I.M.V.d.B.-G., A.M., R.d.V., A.H.J.D., A.J.M.R.), Dept. of Molecular Genetics (I.v.d.P., R.B.), Dept. of Vascular Surgery (I.v.d.P.), Erasmus Medical Center, Rotterdam, The Netherlands, and Intra-Cellular Therapies, Inc., New York, New York (S.D., W.Y., G.L.S., R.E.D.).; Ataei Ataabadi E

Subjects: Aging*/Aging*/Aging*/drug effects ; Blood Pressure*/Blood Pressure*/Blood Pressure*/drug effects ; Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/Cyclic Nucleotide Phosphodiesterases, Type 1*/antagonists & inhibitors

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Aug; Vol. 378 (2), pp. 173-183. Date of Electronic Publication: 2021 Jun 07.Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

PDE1 Inhibition Modulates Ca v 1.2 Channel to Stimulate Cardiomyocyte Contraction.

  • Authors : Muller GK; Division of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.; Song J

Subjects: Myocardial Contraction*; Calcium Channels, L-Type/Calcium Channels, L-Type/Calcium Channels, L-Type/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 1/Cyclic Nucleotide Phosphodiesterases, Type 1/Cyclic Nucleotide Phosphodiesterases, Type 1/*antagonists & inhibitors

  • Source: Circulation research [Circ Res] 2021 Oct 15; Vol. 129 (9), pp. 872-886. Date of Electronic Publication: 2021 Sep 15.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium:

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  • 1-10 of  524 results for ""Cyclic Nucleotide Phosphodiesterases, Type 1""