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Investigation of apoptotic effects of Cucurbitacin D, I, and E mediated by Bax/Bcl-xL, caspase-3/9, and oxidative stress modulators in HepG2 cell line.

• Authors : Üremiş MM; Department of Medical Biochemistry, Medical Faculty, Inonu University, Malatya, Turkey.; Türköz Y

Subjects: Proto-Oncogene Proteins c-bcl-2*/Proto-Oncogene Proteins c-bcl-2*/Proto-Oncogene Proteins c-bcl-2*/metabolism ; Cucurbitacins*/Cucurbitacins*/Cucurbitacins*/pharmacology ; Triterpenes*

• Source: Drug development research [Drug Dev Res] 2024 Apr; Vol. 85 (2), pp. e22174.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print Cited Medium: Internet ISSN: 1098-2299

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Cucurbitacin IIa promotes the immunogenic cell death‑inducing effect of doxorubicin and modulates immune microenvironment in liver cancer.

• Authors : Li S; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.; Wang S

Subjects: Immunogenic Cell Death* ; Liver Neoplasms*/Liver Neoplasms*/Liver Neoplasms*/drug therapy ; Cucurbitacins*

• Source: International journal of oncology [Int J Oncol] 2024 Apr; Vol. 64 (4). Date of Electronic Publication: 2024 Feb 23.Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9306042 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms.

• Authors : Varela C; Chemical Process Engineering and Forest Products (CIEPQPF), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Clinic Academic Center of Coimbra (CACC), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Subjects: Cucurbitacins*/Cucurbitacins*/Cucurbitacins*/pharmacology ; Cucurbitacins*/Cucurbitacins*/Cucurbitacins*/therapeutic use ; Cucurbitacins*/Cucurbitacins*/Cucurbitacins*/chemistry

• Source: Journal of translational medicine [J Transl Med] 2022 Dec 31; Vol. 20 (1), pp. 630. Date of Electronic Publication: 2022 Dec 31.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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Agricola

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Screening and identifying cucurbitacins and cucurbitacin glycosides in Cucumis sativus using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry combined with in-source fragmentation and alkali adduct ions.

• Authors : Chen SY; The First Hospital of Hunan University of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.; Zhou QY

Subjects: Cucumis sativus* ; Cucurbitacins*/Cucurbitacins*/Cucurbitacins*/analysis; Alkalies

• Source: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2022 Jul 30; Vol. 36 (14), pp. e9323.Publisher: John Wiley And Sons Ltd Country of Publication: England NLM ID: 8802365 Publication Model: Print Cited Medium: Internet ISSN:

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Identification and quantification of cucurbitacin in watermelon frost using molecular networking integrated with ultra-high-performance liquid chromatography-tandem mass spectrometry.

• Authors : Hu G; Department of Pharmacy, Medical School, Huanghe Science and Technology University, Zhengzhou, P. R. China.; Liu W

Subjects: Cucurbitacins* ; Citrullus*/Citrullus*/Citrullus*/chemistry; Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/methods

• Source: Journal of separation science [J Sep Sci] 2023 Aug; Vol. 46 (16), pp. e2300019. Date of Electronic Publication: 2023 Jun 03.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101088554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9314

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Cucurbitacins and the Immune System: Update in Research on Anti- inflammatory, Antioxidant, and Immunomodulatory Mechanisms.

• Authors : Silvestre GFG; Department of Pharmacy, Post-graduate Program of Pharmaceuticals Sciences, State University of Paraíba, Campina Grande, Brazil.; de Lucena RP

Subjects: Cucurbitacins*/Cucurbitacins*/Cucurbitacins*/chemistry ; Cucurbitacins*/Cucurbitacins*/Cucurbitacins*/pharmacology ; Cucurbitacins*/Cucurbitacins*/Cucurbitacins*/therapeutic use

• Source: Current medicinal chemistry [Curr Med Chem] 2022; Vol. 29 (21), pp. 3774-3789.Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet

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Synthesis and biological studies of c(RGDyK) conjugates of cucurbitacins.

• Authors : Chatzisideri T; Department of Chemistry, Aristotle University of Thessaloniki, University Campus, Thessaloniki, 54124, Greece.; Dalezis P

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Cucurbitacins/Cucurbitacins/Cucurbitacins/*pharmacology ; Oligopeptides/Oligopeptides/Oligopeptides/*pharmacology

• Source: Future medicinal chemistry [Future Med Chem] 2021 May; Vol. 13 (10), pp. 877-895. Date of Electronic Publication: 2021 Apr 16.Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Watermelon domestication was shaped by stepwise selection and regulation of the metabolome.

• Authors : Yuan P; Henan Joint International Research Laboratory of South Asian Fruits and Cucurbits, Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, Zhengzhou, 450009, China.; Xu C

Subjects: Cucurbitacins* ; Citrullus*/Citrullus*/Citrullus*/genetics ; Citrullus*/Citrullus*/Citrullus*/metabolism

• Source: Science China. Life sciences [Sci China Life Sci] 2023 Mar; Vol. 66 (3), pp. 579-594. Date of Electronic Publication: 2022 Nov 04.Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium:

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Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives.

• Authors : Zhang X; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, People's Republic of China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.

Subjects: Cucurbitacins/Cucurbitacins/Cucurbitacins/*pharmacology ; Hypercholesterolemia/Hypercholesterolemia/Hypercholesterolemia/*blood ; Trichosanthes/Trichosanthes/Trichosanthes/*chemistry

• Source: Journal of natural products [J Nat Prod] 2020 Dec 24; Vol. 83 (12), pp. 3536-3544. Date of Electronic Publication: 2020 Dec 03.Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium:

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