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Academic Journal

Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells.

  • Authors : Choi E; Graduate School of Pharmaceutical Sciences and College of Pharmacy, Ewha Women's University, Seoul, Korea.; Jeon KH

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; BRCA1 Protein* ; Radiation-Sensitizing Agents*/Radiation-Sensitizing Agents*/Radiation-Sensitizing Agents*/pharmacology

  • Source: Cancer science [Cancer Sci] 2024 Jun; Vol. 115 (6), pp. 2036-2048. Date of Electronic Publication: 2024 Apr 13.Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic

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Academic Journal

DNA polymerase α-primase facilitates PARP inhibitor-induced fork acceleration and protects BRCA1-deficient cells against ssDNA gaps.

  • Authors : Machacova Z; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.; Chroma K

Subjects: Poly(ADP-ribose) Polymerase Inhibitors*/Poly(ADP-ribose) Polymerase Inhibitors*/Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology ; DNA Primase*/DNA Primase*/DNA Primase*/metabolism ; DNA Primase*/DNA Primase*/DNA Primase*/genetics

  • Source: Nature communications [Nat Commun] 2024 Aug 27; Vol. 15 (1), pp. 7375. Date of Electronic Publication: 2024 Aug 27.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Systematic investigation of BRCA1-A, -B, and -C complexes and their functions in DNA damage response and DNA repair.

  • Authors : Li S; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Tang M

Subjects: BRCA1 Protein*/BRCA1 Protein*/BRCA1 Protein*/metabolism ; BRCA1 Protein*/BRCA1 Protein*/BRCA1 Protein*/genetics ; DNA Repair*

  • Source: Oncogene [Oncogene] 2024 Aug; Vol. 43 (35), pp. 2621-2634. Date of Electronic Publication: 2024 Jul 27.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Targeting GPX4-mediated ferroptosis protection sensitizes BRCA1-deficient cancer cells to PARP inhibitors.

  • Authors : Xie X; School of Biopharmacy, China Pharmaceutical University, Nanjing, 211198, China; Department of Anesthesiology and General Surgery, The First Affiliated Hospital of Jinan University, 510632, Guangzhou, China.

Subjects: Poly(ADP-ribose) Polymerase Inhibitors*/Poly(ADP-ribose) Polymerase Inhibitors*/Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology ; Ferroptosis*/Ferroptosis*/Ferroptosis*/drug effects ; Ferroptosis*/Ferroptosis*/Ferroptosis*/genetics

  • Source: Redox biology [Redox Biol] 2024 Oct; Vol. 76, pp. 103350. Date of Electronic Publication: 2024 Sep 11.Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination.

  • Authors : Salunkhe S; Department of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Daley JM

Subjects: BRCA1 Protein*/BRCA1 Protein*/BRCA1 Protein*/metabolism ; BRCA1 Protein*/BRCA1 Protein*/BRCA1 Protein*/genetics ; DNA Breaks, Double-Stranded*

  • Source: Nature [Nature] 2024 Oct; Vol. 634 (8033), pp. 482-491. Date of Electronic Publication: 2024 Sep 11.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.

  • Authors : Ceppi I; Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Bellinzona, Switzerland.; Dello Stritto MR

Subjects: BRCA1 Protein*/BRCA1 Protein*/BRCA1 Protein*/metabolism ; BRCA1 Protein*/BRCA1 Protein*/BRCA1 Protein*/genetics ; DNA*/DNA*/DNA*/metabolism

  • Source: Nature [Nature] 2024 Oct; Vol. 634 (8033), pp. 492-500. Date of Electronic Publication: 2024 Sep 11.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Current status and prospect of the DNA double-strand break repair pathway in colorectal cancer development and treatment.

  • Authors : Yang K; Department of Colorectal Surgery, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650106, China; Kunming Medical University, Kunming 650500, China.

Subjects: DNA Breaks, Double-Stranded* ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/genetics ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/metabolism

  • Source: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Oct; Vol. 1870 (7), pp. 167438. Date of Electronic Publication: 2024 Jul 25.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Protocol for evaluating the E3 ligase activity of BRCA1-BARD1 and its variants by nucleosomal histone ubiquitylation.

  • Authors : Fitzgerald O; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.; Wu B

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Nucleosomes*/Nucleosomes*/Nucleosomes*/metabolism

  • Source: STAR protocols [STAR Protoc] 2024 Sep 20; Vol. 5 (3), pp. 103294. Date of Electronic Publication: 2024 Sep 06.Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The DNA double-strand break repair proteins γH2AX, RAD51, BRCA1, RPA70, KU80, and XRCC4 exhibit follicle-specific expression differences in the postnatal mouse ovaries from early to older ages.

  • Authors : Talibova G; Department of Histology and Embryology, Akdeniz University School of Medicine, Campus, 07070, Antalya, Turkey.; Bilmez Y

Subjects: Rad51 Recombinase*/Rad51 Recombinase*/Rad51 Recombinase*/genetics ; Rad51 Recombinase*/Rad51 Recombinase*/Rad51 Recombinase*/metabolism ; DNA Breaks, Double-Stranded*

  • Source: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2024 Sep; Vol. 41 (9), pp. 2419-2439. Date of Electronic Publication: 2024 Jul 18.Publisher: Springer Country of Publication: Netherlands NLM ID: 9206495 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A RAD18-UBC13-PALB2-RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells.

  • Authors : Cybulla E; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; DNA Replication*

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Aug 27; Vol. 52 (15), pp. 8861-8879.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  14,973 results for ""BRCA1 Protein""