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Academic Journal

ADAM10 Expression by Ameloblasts Is Essential for Proper Enamel Formation.

  • Authors : Shahid S; Division of Biosciences, College of Dentistry, Ohio State University, 305 W, 12th Ave., Columbus, OH 43210, USA.; Hu Y

Subjects: ADAM10 Protein*/ADAM10 Protein*/ADAM10 Protein*/metabolism ; ADAM10 Protein*/ADAM10 Protein*/ADAM10 Protein*/genetics ; Ameloblasts*/Ameloblasts*/Ameloblasts*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 07; Vol. 25 (23). Date of Electronic Publication: 2024 Dec 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Activation of the γ-secretase/NICD-PXR/Notch pathway induces Taxol resistance in triple-negative breast cancer.

  • Authors : Wang ZJ; Department of Pharmacy, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang City 110840, Liaoning Province, PR China. Electronic address: .; Zhan XY

Subjects: Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/drug therapy ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/metabolism ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/pathology

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Dec; Vol. 230 (Pt 2), pp. 116577. Date of Electronic Publication: 2024 Oct 19.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Evidence of γ-secretase complex involved in the regulation of intramembrane proteolysis in Entamoeba histolytica.

  • Authors : Makiuchi T; Department of Infectious Diseases, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. Electronic address: .; Saito-Nakano Y

Subjects: Entamoeba histolytica*/Entamoeba histolytica*/Entamoeba histolytica*/genetics ; Entamoeba histolytica*/Entamoeba histolytica*/Entamoeba histolytica*/enzymology ; Entamoeba histolytica*/Entamoeba histolytica*/Entamoeba histolytica*/metabolism

  • Source: Parasitology international [Parasitol Int] 2024 Dec; Vol. 103, pp. 102925. Date of Electronic Publication: 2024 Jul 22.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9708549 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Selective Protonation of Catalytic Dyad for γ-Secretase-Mediated Hydrolysis Revealed by Multiscale Simulations.

  • Authors : Wu B; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.; Li S

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/chemistry ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism ; Molecular Dynamics Simulation*

  • Source: The journal of physical chemistry. B [J Phys Chem B] 2024 Nov 21; Vol. 128 (46), pp. 11345-11358. Date of Electronic Publication: 2024 Nov 07.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet

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Membrane-Targeted Quantum Dot-Based BACE1 Activity Sensors for In Vitro and In Cellulo Assays.

  • Authors : Tosat-Bitrián C; Centro de Investigaciones Biológicas 'Margarita Salas'-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, (CIBERNED), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.

Subjects: Quantum Dots*/Quantum Dots*/Quantum Dots*/chemistry ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/chemistry

  • Source: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Nov 20; Vol. 16 (46), pp. 63186-63194. Date of Electronic Publication: 2024 Nov 08.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet

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Synthetic and non-synthetic inhibition of ADAM10 and ADAM17 reduces inflammation and oxidative stress in LPS-induced acute kidney injury in male and female mice.

  • Authors : Atak M; Recep Tayyip Erdogan University, Faculty of Medicine, Department of Medical Biochemistry, Rize, Turkey. Electronic address: .; Yigit E

Subjects: Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/drug therapy ; Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/chemically induced ; Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/pathology

  • Source: European journal of pharmacology [Eur J Pharmacol] 2024 Nov 15; Vol. 983, pp. 176964. Date of Electronic Publication: 2024 Aug 30.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Sertraline as a Multi-Target Modulator of AChE, COX-2, BACE-1, and GSK-3β: Computational and In Vivo Studies.

  • Authors : Arfeen M; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.; Mani V

Subjects: Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/metabolism ; Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors ; Acetylcholinesterase*/Acetylcholinesterase*/Acetylcholinesterase*/metabolism

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Nov 14; Vol. 29 (22). Date of Electronic Publication: 2024 Nov 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Therapeutic Potential of Ramalin Derivatives with Enhanced Stability in the Treatment of Alzheimer's Disease.

  • Authors : Kim TK; Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 21990, Republic of Korea.; Hong JM

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Nov 05; Vol. 29 (22). Date of Electronic Publication: 2024 Nov 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Virtual screening, ADMET prediction, molecular docking, and dynamic simulation studies of natural products as BACE1 inhibitors for the management of Alzheimer's disease.

  • Authors : Gheidari D; Department of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran. .; Mehrdad M

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors

  • Source: Scientific reports [Sci Rep] 2024 Nov 02; Vol. 14 (1), pp. 26431. Date of Electronic Publication: 2024 Nov 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity.

  • Authors : Matošević A; Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia.; Bartolić M

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/pharmacology

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 01; Vol. 112, pp. 129928. Date of Electronic Publication: 2024 Aug 14.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  9,626 results for ""Amyloid Precursor Protein Secretases""