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Academic Journal

Molecular Docking and Molecular Dynamics Simulations of Synthesized Thiazole-Isatin-1,2,3-triazole Hybrids as Promising Inhibitors for DNA Gyrase and Sterol 14α-Demethylase.

  • Authors : Kumar V; Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, 125001, India.; Kumari P

Subjects: Molecular Docking Simulation* ; Triazoles*/Triazoles*/Triazoles*/chemistry ; Triazoles*/Triazoles*/Triazoles*/pharmacology

  • Source: Chemistry & biodiversity [Chem Biodivers] 2024 Oct; Vol. 21 (10), pp. e202400914. Date of Electronic Publication: 2024 Sep 04.Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Listen to what the animals say: a systematic review and meta-analysis of sterol 14-demethylase inhibitor efficacy for in vivo models of Trypanosoma cruzi infection.

  • Authors : Bisio MMC; Instituto Nacional de Parasitología (INP) 'Dr. Mario Fatala Chaben'-ANLIS 'Dr. Carlos G. Malbrán', Buenos Aires, Argentina. Av. Paseo Colón 568, C1097, Buenos Aires, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Subjects: 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/therapeutic use ; Chagas Disease*/Chagas Disease*/Chagas Disease*/drug therapy

  • Source: Parasitology research [Parasitol Res] 2024 Jun 21; Vol. 123 (6), pp. 248. Date of Electronic Publication: 2024 Jun 21.Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

In silico and in vitro evaluation of designed fluconazole analogues as lanosterol 14α-demethylase inhibitors.

  • Authors : Khichi A; Centre for Bioinformatics, Maharshi Dayanand University, Rohtak, India.; Jakhar R

Subjects: Fluconazole*/Fluconazole*/Fluconazole*/pharmacology ; Fluconazole*/Fluconazole*/Fluconazole*/chemistry ; Molecular Docking Simulation*

  • Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Jun; Vol. 42 (9), pp. 4553-4566. Date of Electronic Publication: 2023 Jun 09.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Novel Pyrido[4,3- d ]pyrimidine Derivatives as Potential Sterol 14α-Demethylase Inhibitors: Design, Synthesis, Inhibitory Activity, and Molecular Modeling.

  • Authors : Yan Y; School of Science, Xihua University, Chengdu 610039, PR China.; Xie X

Subjects: 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/chemistry ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/chemical synthesis Botrytis cinerea; Pyricularia oryzae; Sclerotinia sclerotiorum

  • Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 May 29; Vol. 72 (21), pp. 12260-12269. Date of Electronic Publication: 2024 May 17.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Design, Synthesis, Bioactive Evaluation, and Molecular Dynamics Simulation of Novel 4 H -Pyrano[3,2- c ]pyridine Analogues as Potential Sterol 14α-Demethylase (CYP51) Inhibitors.

  • Authors : Bao A; School of Science, Xihua University, Chengdu 610039, China.; Jiang W

Subjects: 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/chemical synthesis ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/chemistry Botrytis cinerea; Sclerotinia sclerotiorum; Fusarium oxysporum

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 May 23; Vol. 67 (10), pp. 7954-7972. Date of Electronic Publication: 2024 May 04.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14α-Demethylase as a Key Drug Target.

  • Authors : Hargrove TY; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.; Lamb DC

Subjects: Sterol 14-Demethylase*/Sterol 14-Demethylase*/Sterol 14-Demethylase*/metabolism ; Sterol 14-Demethylase*/Sterol 14-Demethylase*/Sterol 14-Demethylase*/chemistry ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 May 09; Vol. 67 (9), pp. 7443-7457. Date of Electronic Publication: 2024 Apr 29.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Strategies of targeting CYP51 for IFIs therapy: Emerging prospects, opportunities and challenges.

  • Authors : Zhang R; Department of Neurology, Joint Research Institution of Altitude Health and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.; Wang Y

Subjects: 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/therapeutic use ; Drug-Related Side Effects and Adverse Reactions*

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 05; Vol. 259, pp. 115658. Date of Electronic Publication: 2023 Jul 17.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

New pyrrole derivatives as DNA gyrase and 14α-demethylase inhibitors: Design, synthesis, antimicrobial evaluation, and molecular docking.

  • Authors : Hilmy KMH; Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt.; Kishk FNM

Subjects: 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology ; DNA Gyrase*/DNA Gyrase*/DNA Gyrase*/metabolism ; DNA Gyrase*/DNA Gyrase*/DNA Gyrase*/pharmacology

  • Source: Drug development research [Drug Dev Res] 2023 Sep; Vol. 84 (6), pp. 1204-1230. Date of Electronic Publication: 2023 May 11.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Design, Synthesis, and Biological Evaluation of Dual-Target COX-2/CYP51 Inhibitors for the Treatment of Fungal Infectious Diseases.

  • Authors : Liu W; Institute of BioPharmaceutical Research, Liaocheng University, 1 Hunan Road, Liaocheng 252000, P. R. China.; Liu Y

Subjects: 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/chemistry ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/therapeutic use

  • Source: Journal of medicinal chemistry [J Med Chem] 2022 Sep 22; Vol. 65 (18), pp. 12219-12239. Date of Electronic Publication: 2022 Sep 08.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Phytochemical profiling of Piper crocatum and its antifungal mechanism action as Lanosterol 14 alpha demethylase CYP51 inhibitor: a review.

  • Authors : Siswina T; Midwifery, Poltekkes Kemenkes Pontianak, Pontianak, Kalimantan Barat, 78124, Indonesia.; Chemistry, Padjadjaran University, Sumedang, Jawa Barat, 45363, Indonesia.

Subjects: Mycoses* ; Piper*/Piper*/Piper*/chemistry ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology

  • Source: F1000Research [F1000Res] 2022 Sep 28; Vol. 11, pp. 1115. Date of Electronic Publication: 2022 Sep 28 (Print Publication: 2022).Publisher: F1000 Research Ltd Country of Publication: England NLM ID: 101594320 Publication Model: eCollection Cited Medium: Internet ISSN:

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  • 1-10 of  304 results for ""14-alpha Demethylase Inhibitors""