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Academic Journal

A review on ubiquitin ligases: Orchestrators of plant resilience in adversity.

Authors : Suranjika S; Institute of Life Sciences (ILS), an autonomous institute under Department of Biotechnology Government of India, NALCO Square, Bhubaneswar, Odisha, India; Department of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), KIIT Road, Patia, Bhubaneswar, Odisha, India.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Stress, Physiological*

Source: Plant science : an international journal of experimental plant biology [Plant Sci] 2024 Oct; Vol. 347, pp. 112180. Date of Electronic Publication: 2024 Jul 02.Publisher: Elsevier Ireland Country of Publication: Ireland NLM ID: 9882015 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Research Progress in the Regulation of the ABA Signaling Pathway by E3 Ubiquitin Ligases in Plants.

Authors : Kou H; State Key Laboratory of Crop Biology, Agronomy College, Shandong Agricultural University, Tai'an 271018, China.; Zhang X

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Abscisic Acid*/Abscisic Acid*/Abscisic Acid*/metabolism ; Signal Transduction*

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 28; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

HucMSCs Delay Muscle Atrophy After Peripheral Nerve Injury Through Exosomes by Repressing Muscle-Specific Ubiquitin Ligases.

Authors : Chen J; School of Medicine, Nankai University, Tianjin, China.; Department of Ultrasound, the First Medical Centre, Chinese PLA General Hospital, Beijing, People's Republic of China.

Subjects: Exosomes*/Exosomes*/Exosomes*/metabolism ; Muscular Atrophy*/Muscular Atrophy*/Muscular Atrophy*/pathology ; Muscular Atrophy*/Muscular Atrophy*/Muscular Atrophy*/metabolism

Source: Stem cells (Dayton, Ohio) [Stem Cells] 2024 May 15; Vol. 42 (5), pp. 460-474.Publisher: Oxford University Press Country of Publication: England NLM ID: 9304532 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins.

Authors : Seo T; Departments of Dermatology and Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, United States of America.; Lowery AM

Subjects: Cadherins*/Cadherins*/Cadherins*/metabolism ; Proteolysis* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

Source: PloS one [PLoS One] 2024 May 09; Vol. 19 (5), pp. e0290485. Date of Electronic Publication: 2024 May 09 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Pink1 balances reticulophagy and mitophagy by regulating distinct E3 ubiquitin ligases.

Authors : Yin Z; Life Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.; Broad Institute of MIT and Harvard, Program in Infectious Disease and Microbiome, Cambridge, MA USA.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Mitophagy*/Mitophagy*/Mitophagy*/physiology; Animals

Source: Autophagy [Autophagy] 2024 May; Vol. 20 (5), pp. 983-984. Date of Electronic Publication: 2024 Mar 08.Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells.

Authors : Rathore U; Gladstone Institutes, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, California, USA.

Subjects: CCAAT-Enhancer-Binding Proteins*/CCAAT-Enhancer-Binding Proteins*/CCAAT-Enhancer-Binding Proteins*/metabolism ; HIV Infections* ; TNF Receptor-Associated Factor 2*/TNF Receptor-Associated Factor 2*/TNF Receptor-Associated Factor 2*/metabolism

Source: MBio [mBio] 2024 Apr 10; Vol. 15 (4), pp. e0222223. Date of Electronic Publication: 2024 Feb 27.Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Identification and Analysis of Subtypes of Liver Cancer Based on Genes Related to E3 Ubiquitin Ligases and Deubiquitinating Enzymes.

Authors : Hu Y; Department of Hepatobiliary Surgery, Yueqing People's Hospital.; Huang P

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Liver Neoplasms*/Liver Neoplasms*/Liver Neoplasms*/genetics

Source: The Tohoku journal of experimental medicine [Tohoku J Exp Med] 2024 Feb 27; Vol. 262 (2), pp. 75-84. Date of Electronic Publication: 2023 Oct 26.Publisher: Tohoku University Medical Library Country of Publication: Japan NLM ID: 0417355 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

A Survey on the Expression of the Ubiquitin Proteasome System Components HECT- and RBR-E3 Ubiquitin Ligases and E2 Ubiquitin-Conjugating and E1 Ubiquitin-Activating Enzymes during Human Brain Development.

Authors : Magnati S; Centro Regionale Anti Doping-A. Bertinaria, Orbassano, 10043 Turin, Italy.; Politecnico di Torino, 10129, Turin, Italy.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Activating Enzymes*/Ubiquitin-Activating Enzymes*/Ubiquitin-Activating Enzymes*/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 17; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Specificities and redundancies in the NEL family of bacterial E3 ubiquitin ligases of Salmonella enterica serovar Typhimurium.

Authors : Bullones-Bolaños A; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain.; Martín-Muñoz P

Subjects: Salmonella typhimurium*/Salmonella typhimurium*/Salmonella typhimurium*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

Source: Frontiers in immunology [Front Immunol] 2024 Feb 01; Vol. 15, pp. 1328707. Date of Electronic Publication: 2024 Feb 01 (Print Publication: 2024).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Targeted Protein Degradation Systems: Controlling Protein Stability Using E3 Ubiquitin Ligases in Eukaryotic Species.

Authors : Ogawa Y; Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan.; Ueda TP

Subjects: Proteasome Endopeptidase Complex* ; Ubiquitin-Protein Ligases*; Proteolysis

Source: Cells [Cells] 2024 Jan 17; Vol. 13 (2). Date of Electronic Publication: 2024 Jan 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

E3 ubiquitin ligases in lung cancer: Emerging insights and therapeutic opportunities.

Authors : Basu B; Cancer Biology and Inflammatory Disorder Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), TRUE Campus, CN-6, Sector-V, Salt Lake, Kolkata- 700091 & 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India.; Kal S

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/genetics

Source: Life sciences [Life Sci] 2024 Jan 01; Vol. 336, pp. 122333. Date of Electronic Publication: 2023 Dec 06.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

As a matter of fat: Emerging roles of lipid-sensitive E3 ubiquitin ligases.

Authors : Gawden-Bone CM; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Lehner PJ

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin*/Ubiquitin*/Ubiquitin*/metabolism; Ubiquitination

Source: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2023 Dec; Vol. 45 (12), pp. e2300139. Date of Electronic Publication: 2023 Oct 27.Publisher: Wiley Country of Publication: United States NLM ID: 8510851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-1878

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Academic Journal

E3 ubiquitin ligases SINA4 and SINA11 regulate anthocyanin biosynthesis by targeting the IAA29-ARF5-1-ERF3 module in apple.

Authors : Li HL; Apple Technology Innovation Center of Shandong Province, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An, Shandong, China.; Liu ZY

Source: Plant, cell & environment [Plant Cell Environ] 2023 Dec; Vol. 46 (12), pp. 3902-3918. Date of Electronic Publication: 2023 Sep 01.Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 9309004 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Role of the Mitochondrial E3 Ubiquitin Ligases as Possible Therapeutic Targets in Cancer Therapy.

Authors : Di Gregorio J; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.; Appignani M

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Neoplasms*/Neoplasms*/Neoplasms*/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 06; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

A critical discussion on the relationship between E3 ubiquitin ligases, protein degradation, and skeletal muscle wasting: it's not that simple.

Authors : Hughes DC; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States.; Goodman CA

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/metabolism; Humans

Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2023 Dec 01; Vol. 325 (6), pp. C1567-C1582. Date of Electronic Publication: 2023 Nov 13.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Regulatory role of E3 ubiquitin ligases in normal B lymphopoiesis and B-cell malignancies.

Authors : Xu Y; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Neoplasms*; Humans

Source: Life sciences [Life Sci] 2023 Oct 15; Vol. 331, pp. 122043. Date of Electronic Publication: 2023 Aug 24.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Knockout of GRAIN WIDTH2 has a dual effect on enhancing leaf rust resistance and increasing grain weight in wheat.

Authors : Liu, Shujuan^1,2 (AUTHOR); Liu, Hong³ (AUTHOR); Guo, Mengjiao² (AUTHOR)

Subjects: *UBIQUITIN ligases; *LEAF rust of wheat; *WINTER wheat

Source: Plant Biotechnology Journal. Jul2024, Vol. 22 Issue 7, p2007-2009. 3p.

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Academic Journal

You can "tail" them apart: paralog-specific functions of CRL4B ubiquitin ligases during mitosis and brain development.

Authors : Baxi A; Stem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.; Werner A

Subjects: Ubiquitin* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

Source: The EMBO journal [EMBO J] 2023 Sep 04; Vol. 42 (17), pp. e114931. Date of Electronic Publication: 2023 Aug 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

E3 Ubiquitin Ligases in Endothelial Dysfunction and Vascular Diseases: Roles and Potential Therapies.

Authors : Wang Y; National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.; Zhan Y

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Vascular Diseases*/Vascular Diseases*/Vascular Diseases*/drug therapy; Humans

Source: Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2023 Aug 01; Vol. 82 (2), pp. 93-103. Date of Electronic Publication: 2023 Aug 01.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7902492 Publication Model: Electronic Cited Medium: Internet

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Academic Journal

E3 ubiquitin ligases and deubiquitinases in bladder cancer tumorigenesis and implications for immunotherapies.

Authors : Wang M; Department of Urology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.; Zhang Z

Subjects: Ubiquitin-Protein Ligases* ; Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/therapy; Humans

Source: Frontiers in immunology [Front Immunol] 2023 Jul 11; Vol. 14, pp. 1226057. Date of Electronic Publication: 2023 Jul 11 (Print Publication: 2023).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

A basic charge cluster near the C-terminus of the cytoplasmic tail contributes to the molecular stability of human herpesvirus 8 E3 ubiquitin ligases.

Authors : Kajikawa M; Laboratory of Microbiology, Showa Pharmaceutical University, Machida, Japan.; Kato K

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Herpesvirus 8, Human*/Herpesvirus 8, Human*/Herpesvirus 8, Human*/genetics

Source: Microbiology and immunology [Microbiol Immunol] 2023 Jun; Vol. 67 (6), pp. 293-302. Date of Electronic Publication: 2023 Apr 17.Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 7703966 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

E3 ubiquitin ligases in cancer stem cells: key regulators of cancer hallmarks and novel therapeutic opportunities.

Authors : Zou Q; Department of Hepatobiliary Pancreatic Tumor Center, Chongqing University Cancer Hospital, Chongqing University Medical School, Chongqing, 400030, People's Republic of China.; Department of Gastroenterology & Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, People's Republic of China.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Neoplasms*/Neoplasms*/Neoplasms*/metabolism; Humans

Source: Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2023 Jun; Vol. 46 (3), pp. 545-570. Date of Electronic Publication: 2023 Feb 06.Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer .

Authors : Scalia P; ISOPROG-Somatolink EPFP Research Network, Philadelphia, PA 19102, USA; 93100 Caltanissetta, Italy.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Neoplasms*/Neoplasms*/Neoplasms*/genetics; Humans

Source: Cells [Cells] 2023 Jun 21; Vol. 12 (13). Date of Electronic Publication: 2023 Jun 21.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.

Authors : Scortegagna M; NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.; Du Y

Subjects: Macrophages, Alveolar*/Macrophages, Alveolar*/Macrophages, Alveolar*/enzymology ; Macrophages, Alveolar*/Macrophages, Alveolar*/Macrophages, Alveolar*/immunology ; Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/chemically induced

Source: Cancer research [Cancer Res] 2023 Jun 15; Vol. 83 (12), pp. 2016-2033.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium:

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Academic Journal

The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy.

Authors : Wang X; Department of Pathology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China.; Zhang Y

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/physiology ; Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/therapy; Humans

Source: Frontiers in immunology [Front Immunol] 2023 May 05; Vol. 14, pp. 1202633. Date of Electronic Publication: 2023 May 05 (Print Publication: 2023).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy.

Authors : Sampson C; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.; University of Chinese Academy of Sciences, Beijing, China.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy; Humans

Source: Clinical and translational medicine [Clin Transl Med] 2023 Mar; Vol. 13 (3), pp. e1204.Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326

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Academic Journal

Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer.

Authors : Sun A; School of Medicine, Jiangsu University, Zhenjiang, China.; Department of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Stomach Neoplasms*; Humans

Source: Pathology oncology research : POR [Pathol Oncol Res] 2023 Feb 07; Vol. 29, pp. 1610931. Date of Electronic Publication: 2023 Feb 07 (Print Publication: 2023).Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 9706087 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Identification and Characterization of Physiological Pairing of E2 Ubiquitin-Conjugating Enzymes and E3 Ubiquitin Ligases.

Authors : Brillada C; Faculty of Biology, Cell Biology, University of Freiburg, Freiburg, Germany.; Trujillo M

Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2581, pp. 13-29.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Academic Journal

The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives.

Authors : Zhang R; Department of Thoracic Surgery, The Seventh People's Hospital of Chengdu, Chengdu, 610021, Sichuan, People's Republic of China.; Shi S

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Neoplasms*/Neoplasms*/Neoplasms*/therapy; Nedd4 Ubiquitin Protein Ligases/Nedd4 Ubiquitin Protein Ligases/Nedd4 Ubiquitin Protein Ligases/genetics

Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2023 Mar 14; Vol. 29 (1), pp. 34. Date of Electronic Publication: 2023 Mar 14.Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658

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Academic Journal

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.

Authors : Hayashida R; Ubiquitin Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.

Subjects: Ubiquitin-Conjugating Enzymes*/Ubiquitin-Conjugating Enzymes*/Ubiquitin-Conjugating Enzymes*/chemistry ; Ubiquitin-Conjugating Enzymes*/Ubiquitin-Conjugating Enzymes*/Ubiquitin-Conjugating Enzymes*/isolation & purification ; Ubiquitin-Conjugating Enzymes*/Ubiquitin-Conjugating Enzymes*/Ubiquitin-Conjugating Enzymes*/metabolism

Source: The Journal of biological chemistry [J Biol Chem] 2023 Feb; Vol. 299 (2), pp. 102822. Date of Electronic Publication: 2022 Dec 21.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

In vitro autoubiquitination activity of E3 ubiquitin ligases of the N-degron pathway.

Authors : Sandmann A; Department of Plant Physiology and Protein Metabolism Laboratory, University of Osnabruck, Osnabruck, Germany; CellNanOs-Center of Cellular Nanoanalytics, University of Osnabruck, Osnabruck, Germany

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Conjugating Enzymes*/Ubiquitin-Conjugating Enzymes*/Ubiquitin-Conjugating Enzymes*/metabolism

Source: Methods in enzymology [Methods Enzymol] 2023; Vol. 686, pp. 205-220. Date of Electronic Publication: 2023 Mar 24.Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Functional roles of E3 ubiquitin ligases in prostate cancer.

Authors : Zhao Y; Department of Oncology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, 315020, China.; Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.

Subjects: Prostatic Neoplasms* ; Ubiquitin-Protein Ligases*; Humans

Source: Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2022 Aug; Vol. 100 (8), pp. 1125-1144. Date of Electronic Publication: 2022 Jul 11.Publisher: Springer International Country of Publication: Germany NLM ID: 9504370 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Antibody targeting of E3 ubiquitin ligases for receptor degradation.

Authors : Marei H; Discovery Oncology, Genentech, South San Francisco, CA, USA.; Tsai WK

Subjects: Antibodies*/Antibodies*/Antibodies*/immunology ; Antibodies*/Antibodies*/Antibodies*/metabolism ; Antibody Specificity*

Source: Nature [Nature] 2022 Oct; Vol. 610 (7930), pp. 182-189. Date of Electronic Publication: 2022 Sep 21.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome.

Authors : Wang R; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.; You X

Subjects: Oryza*/Oryza*/Oryza*/genetics ; Oryza*/Oryza*/Oryza*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics

Source: Genome biology [Genome Biol] 2022 Jul 11; Vol. 23 (1), pp. 154. Date of Electronic Publication: 2022 Jul 11.Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

E3 ubiquitin ligases and cerebral cortex development in health and disease.

Authors : Lambert N; Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells and GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, CHU Sart Tilman, Liège, Belgium.; Department of Neurology, University Hospital of Liège, Liège, Belgium.

Subjects: Ubiquitin*/Ubiquitin*/Ubiquitin*/genetics ; Ubiquitin*/Ubiquitin*/Ubiquitin*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics

Source: Developmental neurobiology [Dev Neurobiol] 2022 Jul; Vol. 82 (5), pp. 392-407. Date of Electronic Publication: 2022 May 09.Publisher: Wiley Subscription Services, Inc Country of Publication: United States NLM ID: 101300215 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

The differentially expressed gene signatures of the Cullin 3-RING ubiquitin ligases in neuroendocrine cancer.

Authors : Park JU; Department of Biochemistry, Chungbuk National University, Cheongju, 28644, Republic of Korea.; Kim DK

Subjects: Carcinoma, Neuroendocrine* ; Cullin Proteins*/Cullin Proteins*/Cullin Proteins*/genetics ; Cullin Proteins*/Cullin Proteins*/Cullin Proteins*/metabolism

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 25; Vol. 636 (Pt 2), pp. 71-78. Date of Electronic Publication: 2022 Nov 08.Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Editorial & Opinion

E3 ubiquitin ligases: A therapeutic drug target in head and neck squamous cell carcinoma.

Authors : Krishnamoorthy K; Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai 600077, India.; Priya Veeraraghavan V

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Head and Neck Neoplasms*/Head and Neck Neoplasms*/Head and Neck Neoplasms*/drug therapy; Humans

Source: Oral oncology [Oral Oncol] 2022 Dec; Vol. 135, pp. 106193. Date of Electronic Publication: 2022 Oct 12.Publisher: Elsevier Country of Publication: England NLM ID: 9709118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0593

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The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.

Authors : Zeng LW; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University; Medical Research Institute

Subjects: Asthma* ; Eosinophilia*; Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/*metabolism

Source: Cellular & molecular immunology [Cell Mol Immunol] 2022 Oct; Vol. 19 (10), pp. 1117-1129. Date of Electronic Publication: 2022 Aug 19.Publisher: Chinese Society of Immunology;; _b Nature Pub. Group Country of Publication: China NLM ID: 101242872 Publication Model: Print-Electronic Cited

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The HECT family of E3 ubiquitin ligases and PTEN.

Authors : Song MS; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX77030, USA. Electronic address: .; Pandolfi PP

Subjects: PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/genetics ; PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics

Source: Seminars in cancer biology [Semin Cancer Biol] 2022 Oct; Vol. 85, pp. 43-51. Date of Electronic Publication: 2021 Jun 12.Publisher: Academic Press Country of Publication: England NLM ID: 9010218 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Ubiquitin ligases at the nexus of plant responses to biotic and abiotic stresses.

Authors : Stone SL; Department of Biology, Dalhousie University, 1355 Oxford Street, 5134 Life Science Center (LSC), Halifax, Canada.

Subjects: Ubiquitin*/Ubiquitin*/Ubiquitin*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Plants/Plants/Plants/metabolism

Source: Essays in biochemistry [Essays Biochem] 2022 Aug 05; Vol. 66 (2), pp. 123-133.Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 0043306 Publication Model: Print Cited Medium:

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The NEL Family of Bacterial E3 Ubiquitin Ligases.

Authors : Bullones-Bolaños A; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain.; Bernal-Bayard J

Subjects: Type III Secretion Systems*/Type III Secretion Systems*/Type III Secretion Systems*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Bacteria/Bacteria/Bacteria/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2022 Jul 13; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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The Role of E3 Ubiquitin Ligases in Chloroplast Function.

Authors : Hand KA; Department of Plant Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA.; Shabek N

Subjects: Chloroplasts*/Chloroplasts*/Chloroplasts*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Chloroplast Proteins/Chloroplast Proteins/Chloroplast Proteins/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2022 Aug 25; Vol. 23 (17). Date of Electronic Publication: 2022 Aug 25.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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An integrative pan-cancer analysis revealing the difference in small ring finger family of SCF E3 ubiquitin ligases.

Authors : Huang T; Department of Medical Oncology, Xiang'an Hospital of Xiamen University, Xiamen, China.; Department of Medical Oncology, Xiamen Key Laboratory of Endocrine-Related Cancer Precision Medicine, Xiamen, China.

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/genetics ; Neoplasms*/Neoplasms*/Neoplasms*/metabolism ; SKP Cullin F-Box Protein Ligases*/SKP Cullin F-Box Protein Ligases*/SKP Cullin F-Box Protein Ligases*/genetics

Source: Frontiers in immunology [Front Immunol] 2022 Aug 18; Vol. 13, pp. 968777. Date of Electronic Publication: 2022 Aug 18 (Print Publication: 2022).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet

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Ubiquitination-coupled liquid phase separation regulates the accumulation of the TRIM family of ubiquitin ligases into cytoplasmic bodies.

Authors : Tozawa T; Department of Applied Chemistry, National Defense Academy, Yokosuka, Kanagawa, Japan.; Matsunaga K

Subjects: Ubiquitin*/Ubiquitin*/Ubiquitin*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Chromatography, Liquid

Source: PloS one [PLoS One] 2022 Aug 05; Vol. 17 (8), pp. e0272700. Date of Electronic Publication: 2022 Aug 05 (Print Publication: 2022).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Negative regulation of receptor tyrosine kinases by ubiquitination: Key roles of the Cbl family of E3 ubiquitin ligases.

Authors : Tang R; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, China.; Langdon WY

Subjects: Ubiquitin*/Ubiquitin*/Ubiquitin*/metabolism ; Ubiquitin-Protein Ligases*; Animals

Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Jul 28; Vol. 13, pp. 971162. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print

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Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases.

Authors : Dubey AR; Department of Bioscience and Bioengineering, Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India.; Jagtap YA

Subjects: Ubiquitin-Protein Ligases/Ubiquitin-Protein Ligases/Ubiquitin-Protein Ligases/*physiology ; Viral Proteins/Viral Proteins/Viral Proteins/*physiology ; Virus Diseases/Virus Diseases/Virus Diseases/*enzymology

Source: Journal of cellular biochemistry [J Cell Biochem] 2022 Feb; Vol. 123 (2), pp. 161-182. Date of Electronic Publication: 2021 Sep 14.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8205768 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Regulation of Notch signaling by E3 ubiquitin ligases.

Authors : Dutta D; Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, India.; Sharma V

Subjects: Receptors, Notch/Receptors, Notch/Receptors, Notch/*metabolism ; Ubiquitin-Protein Ligases/Ubiquitin-Protein Ligases/Ubiquitin-Protein Ligases/*metabolism; Humans

Source: The FEBS journal [FEBS J] 2022 Feb; Vol. 289 (4), pp. 937-954. Date of Electronic Publication: 2021 Mar 16.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases.

Authors : Aublette MC; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom.; Harrison TA

Subjects: Proteolysis* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Ligands

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 May 15; Vol. 64, pp. 128636. Date of Electronic Publication: 2022 Feb 26.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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How the ends signal the end: Regulation by E3 ubiquitin ligases recognizing protein termini.

Authors : Sherpa D; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Bavaria, Germany.; Chrustowicz J

Subjects: Ubiquitin*/Ubiquitin*/Ubiquitin*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Amino Acid Motifs

Source: Molecular cell [Mol Cell] 2022 Apr 21; Vol. 82 (8), pp. 1424-1438. Date of Electronic Publication: 2022 Mar 04.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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PUB22 and PUB23 U-box E3 ubiquitin ligases negatively regulate 26S proteasome activity under proteotoxic stress conditions.

Authors : Ahn MY; Department of Systems Biology, Division of Life Science, Yonsei University, Seoul, 03722, Korea.; Institute of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Korea.

Subjects: Arabidopsis*/Arabidopsis*/Arabidopsis*/metabolism ; Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/metabolism; Arabidopsis Proteins/Arabidopsis Proteins/Arabidopsis Proteins/*metabolism

Source: Journal of integrative plant biology [J Integr Plant Biol] 2022 Mar; Vol. 64 (3), pp. 625-631. Date of Electronic Publication: 2022 Jan 28.Publisher: Wiley-Blackwell Pub Country of Publication: China (Republic : 1949- ) NLM ID: 101250502 Publication Model: Print-Electronic Cited Medium:

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