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Academic Journal

Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice.

  • Authors : Togashi T; Department of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan (T.T., E.M.).; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, Japan (T.T., N.B., Y.K., M.H., T.H., T.O.).

Subjects: Protein C*/Protein C*/Protein C*/metabolism ; Protein C*/Protein C*/Protein C*/genetics ; Gene Editing*/Gene Editing*/Gene Editing*/methods

  • Source: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2024 Dec; Vol. 44 (12), pp. 2616-2627. Date of Electronic Publication: 2024 Nov 07.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

[Molecular Mechanism of Protein C Deficiency Caused by Mutations of PROC Gene N355S, G392E, T314A].

  • Authors : Li TY; Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Suzhou 215006, Jiangsu Province, China.; State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, Jiangsu Province, China.

Subjects: Protein C*/Protein C*/Protein C*/genetics ; Protein C*/Protein C*/Protein C*/metabolism ; Transfection*

  • Source: Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2024 Dec; Vol. 32 (6), pp. 1834-1840.Publisher: Zhongguo shi yan xue za zhi she Country of Publication: China NLM ID: 101084424 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Cytoprotective 3K3A-activated protein C and plasma: A comparison of therapeutics for the endotheliopathy of trauma.

  • Authors : Thielen O; From the University of Colorado, Department of Surgery, Division Gastrointestinal, Trauma, and Endocrine Surgery, Aurora, CO (O.T., P.S., M.D., M.K., S.M., W.H., L.T.G., T.S., B.S., B.R., A.D., K.H., C.C.S., E.M., M.C.); The Ernest E Moore Shock Trauma Center at Denver Health, Denver Health Medical Center, Department of Surgery, Denver, CO (E.M.)

Subjects: Wounds and Injuries*/Wounds and Injuries*/Wounds and Injuries*/complications ; Wounds and Injuries*/Wounds and Injuries*/Wounds and Injuries*/therapy ; Protein C*/Protein C*/Protein C*/therapeutic use

  • Source: The journal of trauma and acute care surgery [J Trauma Acute Care Surg] 2025 Jan 01; Vol. 98 (1), pp. 94-100. Date of Electronic Publication: 2024 May 27.Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 101570622 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Assessment of Hypercoagulability in Splanchnic Vein Thrombosis by Measurement of the Hemostasis Enzymes Thrombin and Activated Protein C.

  • Authors : Reda S; Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, 53127 Bonn, Germany.; Department of Transfusion Medicine, University Hospital Cologne, 50937 Cologne, Germany.

Subjects: Protein C*/Protein C*/Protein C*/metabolism ; Venous Thrombosis*/Venous Thrombosis*/Venous Thrombosis*/blood ; Venous Thrombosis*/Venous Thrombosis*/Venous Thrombosis*/etiology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 31; Vol. 26 (1). Date of Electronic Publication: 2024 Dec 31.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid.

  • Authors : Sim DS; Coagulant Therapeutics Corporation, Berkeley, CA.; Shukla M

Subjects: Protein C*/Protein C*/Protein C*/metabolism; Humans ; Amino Acid Substitution

  • Source: Blood advances [Blood Adv] 2025 Jan 14; Vol. 9 (1), pp. 180-191.Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet

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Academic Journal

Specific DNA aptamer-immobilized cryogel membranes as novel bioaffinity supports and their potential for the purification of activated protein C.

Subjects: Cryogels*/Cryogels*/Cryogels*/chemistry ; Protein C*/Protein C*/Protein C*/chemistry ; Protein C*/Protein C*/Protein C*/isolation & purification

  • Source: Biomedical chromatography : BMC [Biomed Chromatogr] 2024 Nov; Vol. 38 (11), pp. e5995. Date of Electronic Publication: 2024 Aug 27.Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0801

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Academic Journal

An orthosteric/allosteric bivalent peptide agonist comprising covalently linked protease-activated receptor-derived peptides mimics in vitro and in vivo activities of activated protein C.

  • Authors : Healy LD; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.; Fernández JA

Subjects: Protein C*/Protein C*/Protein C*/metabolism ; Protein C*/Protein C*/Protein C*/chemistry ; Receptor, PAR-1*/Receptor, PAR-1*/Receptor, PAR-1*/agonists

  • Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Jul; Vol. 22 (7), pp. 2039-2051. Date of Electronic Publication: 2024 Apr 24.Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836

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Academic Journal

A Novel Murine Model Enabling rAAV8-PC Gene Therapy for Severe Protein C Deficiency.

  • Authors : Levy-Mendelovich S; National Hemophilia Center, Thrombosis & Hemostasis Institute, Sheba Medical Center, Ramat Gan 52621, Israel.; Amalia Biron Research Institute of Thrombosis & Hemostasis, Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.

Subjects: Genetic Therapy*/Genetic Therapy*/Genetic Therapy*/methods ; Dependovirus*/Dependovirus*/Dependovirus*/genetics ; Disease Models, Animal*

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 26; Vol. 25 (19). Date of Electronic Publication: 2024 Sep 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Analysis of four hereditary protein C deficiencies associated with vascular thromboembolism.

  • Authors : Chen X; Department of Neurology, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325003, China.; Yuan C

Subjects: Protein C Deficiency*/Protein C Deficiency*/Protein C Deficiency*/genetics ; Protein C Deficiency*/Protein C Deficiency*/Protein C Deficiency*/complications ; Protein C*/Protein C*/Protein C*/genetics

  • Source: Annals of hematology [Ann Hematol] 2024 Jun; Vol. 103 (6), pp. 2145-2155. Date of Electronic Publication: 2024 Mar 04.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Protein C and S activities in COVID-19: A systematic review and meta-analysis.

  • Authors : Khoshnegah Z; Department of Hematology and Blood Banking, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.; Siyadat P

Subjects: COVID-19*/COVID-19*/COVID-19*/blood ; Protein C*/Protein C*/Protein C*/metabolism ; Protein S*/Protein S*/Protein S*/metabolism

  • Source: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2024 Aug; Vol. 57 (6), pp. 1018-1030. Date of Electronic Publication: 2024 May 09.Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9502018 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Validation for the function of protein C in mouse models.

  • Authors : Liu Y; Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Guangdong Medical University, Zhanjiang, Guangdong, China.; Cai M

Subjects: Protein C*/Protein C*/Protein C*/metabolism ; Protein C*/Protein C*/Protein C*/genetics ; Disease Models, Animal*

  • Source: PeerJ [PeerJ] 2024 Apr 24; Vol. 12, pp. e17261. Date of Electronic Publication: 2024 Apr 24 (Print Publication: 2024).Publisher: PeerJ Inc Country of Publication: United States NLM ID: 101603425 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Mutation Ter462GlnextTer17 introduces a tail to C-terminus of protein C and causes venous thrombosis.

  • Authors : Lai Z; Department of Laboratory Medicine, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.; Li J

Subjects: Mutation* ; Protein C*/Protein C*/Protein C*/metabolism ; Protein C*/Protein C*/Protein C*/genetics

  • Source: Thrombosis research [Thromb Res] 2024 Aug; Vol. 240, pp. 109044. Date of Electronic Publication: 2024 May 29.Publisher: Pergamon Press Country of Publication: United States NLM ID: 0326377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Met343Val mutation disrupts the shuttling of Trp380 leading to a low-activity conformer of activated protein C and causes thrombosis.

  • Authors : Zhou S; Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Li F

Subjects: Protein C*/Protein C*/Protein C*/metabolism ; Protein C*/Protein C*/Protein C*/genetics ; Thrombosis*/Thrombosis*/Thrombosis*/genetics

  • Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Aug; Vol. 22 (8), pp. 2270-2280. Date of Electronic Publication: 2024 May 23.Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836

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Academic Journal

Characteristics of factor V and protein C based on results from Korean testing centers.

  • Authors : Na MJ; Department of Biomedical Laboratory Science, Dankook University College of Health Sciences, Chungnam, Republic of Korea.; Kim JK

Subjects: Protein C*/Protein C*/Protein C*/analysis ; Factor V*/Factor V*/Factor V*/analysis ; Thrombosis*/Thrombosis*/Thrombosis*/blood

  • Source: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis [Blood Coagul Fibrinolysis] 2024 Jun 01; Vol. 35 (4), pp. 173-179. Date of Electronic Publisher: Lippincott Williams And Wilkins Country of Publication: England NLM ID: 9102551 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

EVALUATION OF PROTEIN C AND S IN Β-THALASSEMIA MAJOR.

  • Authors : Ali A; 1Ibn Sina Teaching Hospital, Ninevah Health Directorate, Mosul, Iraq.; Kashmoola M

Subjects: beta-Thalassemia*/beta-Thalassemia*/beta-Thalassemia*/blood ; Protein C*/Protein C*/Protein C*/metabolism ; Protein C*/Protein C*/Protein C*/analysis

  • Source: Georgian medical news [Georgian Med News] 2024 Jul-Aug (352-353), pp. 155-160.Publisher: Assot︠s︡iat︠s︡ii︠a︡ delovoĭ pressy Gruzii Country of Publication: Georgia (Republic) NLM ID: 101218222 Publication Model: Print

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Academic Journal

Protein C Pretreatment Protects Endothelial Cells from SARS-CoV-2-Induced Activation.

  • Authors : Silva BRDS; School of Nursing, Universidade Estadual de Campinas, Campinas 13083-970, SP, Brazil.; Laboratory of Cell Signalling, Obesity and Comorbidities Center (OCRC), Universidade Estadual de Campinas, Campinas 13083-970, SP, Brazil.

Subjects: COVID-19*/COVID-19*/COVID-19*/virology ; Endothelial Cells*/Endothelial Cells*/Endothelial Cells*/metabolism ; Endothelial Cells*/Endothelial Cells*/Endothelial Cells*/virology

  • Source: Viruses [Viruses] 2024 Jun 28; Vol. 16 (7). Date of Electronic Publication: 2024 Jun 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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Academic Journal

Mimicking activated protein C-progress by PARtnering peptides.

  • Authors : Fleming H; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland; National Children's Research Centre, Children's Health Ireland Crumlin, Dublin, Ireland.

Subjects: Protein C*/Protein C*/Protein C*/metabolism; Humans ; Peptides/Peptides/Peptides/chemistry

  • Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Aug; Vol. 22 (8), pp. 2153-2155.Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print Cited Medium: Internet ISSN: 1538-7836

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Editorial & Opinion

Editorial Expression of Concern: Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.

  • Authors : Cheng T; Department of Neurosurgery, Frank P. Smith Laboratory for Neuroscience and Neurosurgical Research, University of Rochester Medical Center, Rochester, 14642, New York, USA.; Petraglia AL

Subjects: Tissue Plasminogen Activator*/Tissue Plasminogen Activator*/Tissue Plasminogen Activator*/adverse effects ; Protein C*/Protein C*/Protein C*/metabolism; Humans

  • Source: Nature medicine [Nat Med] 2024 Jun; Vol. 30 (6), pp. 1792.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.

  • Authors : Xue M; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.; The Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.

Subjects: Protein C*/Protein C*/Protein C*/metabolism ; Dermatitis, Allergic Contact*/Dermatitis, Allergic Contact*/Dermatitis, Allergic Contact*/drug therapy ; Recombinant Proteins*

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Unraveling the Molecular Mechanisms of Activated Protein C (APC) in Mitigating Reperfusion Injury and Cardiac Ischemia: a Promising Avenue for Novel Therapeutic Interventions.

  • Authors : Johri N; Department of Pharmacy Practice & Pharmacology, Teerthanker Mahaveer College of Pharmacy, Moradabad, Uttar Pradesh, India. .; School of Health & Psychological Sciences, City, University of London, London, United Kingdom. .

Subjects: Myocardial Reperfusion Injury*/Myocardial Reperfusion Injury*/Myocardial Reperfusion Injury*/prevention & control ; Myocardial Reperfusion Injury*/Myocardial Reperfusion Injury*/Myocardial Reperfusion Injury*/metabolism ; Myocardial Reperfusion Injury*/Myocardial Reperfusion Injury*/Myocardial Reperfusion Injury*/physiopathology

  • Source: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2024 Apr; Vol. 17 (2), pp. 345-355. Date of Electronic Publication: 2023 Oct 18.Publisher: Springer Country of Publication: United States NLM ID: 101468585 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Ser252Asn Mutation Introduces a New N-Linked Glycosylation Site and Causes Type IIb Protein C Deficiency.

  • Authors : Zhou S; Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Wu X

Subjects: Protein C*/Protein C*/Protein C*/metabolism ; Protein C*/Protein C*/Protein C*/genetics ; Protein C*/Protein C*/Protein C*/chemistry

  • Source: Thrombosis and haemostasis [Thromb Haemost] 2024 May; Vol. 124 (5), pp. 459-470. Date of Electronic Publication: 2023 Nov 27.Publisher: Thieme Country of Publication: Germany NLM ID: 7608063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2567-689X

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Academic Journal

Efficient production of peptidylglycine α-hydroxylating monooxygenase in yeast for protein C-terminal functionalization.

  • Authors : Zhu T; AIM center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; Zhang X

Subjects: Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/genetics ; Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/metabolism ; Protein C*

  • Source: International journal of biological macromolecules [Int J Biol Macromol] 2024 Apr; Vol. 263 (Pt 2), pp. 130443. Date of Electronic Publication: 2024 Feb 27.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Activated protein C and free protein S in patients with mild to moderate bleeding disorders.

  • Authors : Mehic D; Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.; Schramm T

Subjects: Protein C* ; Blood Coagulation Disorders*; Humans

  • Source: Thrombosis research [Thromb Res] 2024 Mar; Vol. 235, pp. 98-106. Date of Electronic Publication: 2024 Jan 26.Publisher: Pergamon Press Country of Publication: United States NLM ID: 0326377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Development of an assay using a modified coagulation factor V to measure protein S activity.

  • Authors : Maruyama K; Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Japan.; Kokame K

Subjects: Protein S*/Protein S*/Protein S*/metabolism ; Protein S*/Protein S*/Protein S*/genetics ; Blood Coagulation*

  • Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Dec; Vol. 22 (12), pp. 3510-3520. Date of Electronic Publication: 2024 Sep 05.Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836

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Academic Journal

A potential mechanism for the cytoprotective effects of activated protein C-released endothelial extracellular vesicles.

  • Authors : Das K; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.; Keshava S

Subjects: Extracellular Vesicles*/Extracellular Vesicles*/Extracellular Vesicles*/metabolism ; Protein C*/Protein C*/Protein C*/metabolism ; Cytoprotection*

  • Source: Blood [Blood] 2024 Apr 18; Vol. 143 (16), pp. 1670-1675.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020

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  • 1-25 of  263,944 results for ""Protein C""