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Academic Journal

Coproporphyrin-I as a Selective OATP1B Biomarker Can Be Used to Delineate the Mechanisms of Complex Drug-Drug Interactions: Cedirogant Case Study.

  • Authors : Kikuchi R; Quantitative, Translational and ADME Sciences, AbbVie Inc., North Chicago, Illinois, USA.; Qian Y

Subjects: Drug Interactions* ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Nov; Vol. 116 (5), pp. 1334-1342. Date of Electronic Publication: 2024 Aug 05.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Academic Journal

Molecular Mechanisms for the Selective Transport of Dichlorofluorescein by Human Organic Anion Transporting Polypeptide 1B1.

  • Authors : Liu H; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China (H.L., L.L., T.L., R.H., C.G.); and Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (B.H.).

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/metabolism

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Oct 16; Vol. 52 (11), pp. 1323-1331. Date of Electronic Publication: 2024 Oct 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe.

  • Authors : Kinzi J; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; Grube M

Subjects: Ezetimibe*/Ezetimibe*/Ezetimibe*/administration & dosage ; Ezetimibe*/Ezetimibe*/Ezetimibe*/pharmacology ; Ezetimibe*/Ezetimibe*/Ezetimibe*/pharmacokinetics

  • Source: Clinical and translational science [Clin Transl Sci] 2024 Oct; Vol. 17 (10), pp. e70041.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic Organic Anion-Transporting Polypeptide 1B-Mediated Clinical Drug-Drug Interactions.

  • Authors : Feng B; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., G.L., C.Z., S.L., H.H., J.W., H.G., S.K.) and PhoenixBio USA Corporation, New York, New York (Y.M.) .; Liang G

Subjects: Drug Interactions* ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Sep 16; Vol. 52 (10), pp. 1073-1082. Date of Electronic Publication: 2024 Sep 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Systematic Evaluation of Tyrosine Kinase Inhibitors as OATP1B1 Substrates Using a Competitive Counterflow Screen.

  • Authors : Drabison T; Division of Pharmaceutics and Pharmacology, College of Pharmacy, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.; Boeckman M

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics

  • Source: Cancer research communications [Cancer Res Commun] 2024 Sep 01; Vol. 4 (9), pp. 2489-2497.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium:

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Academic Journal

Rapid Detection of SLCO1B1 Polymorphisms Using Duplex Fluorescence Melting Curve Analysis: Implications for Personalized Drug Dosing in Clinical Settings.

  • Authors : Yu Z; Institute of Basic Medical Sciences, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, 514031, People's Republic of China.; Guangdong Engineering Technological Research Center of Clinical Molecular Diagnosis and Antibody Drugs, Meizhou Academy of Medical Sciences, Meizhou, 514031, People's Republic of China.

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics; Humans ; Middle Aged

  • Source: Drug design, development and therapy [Drug Des Devel Ther] 2024 Nov 03; Vol. 18, pp. 4889-4899. Date of Electronic Publication: 2024 Nov 03 (Print Publication: 2024).Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Characterization and Prediction of Organic Anion Transporting Polypeptide 1B Activity in Prostate Cancer Patients on Abiraterone Acetate Using Endogenous Biomarker Coproporphyrin I.

  • Authors : Wang Z; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Coproporphyrins*/Coproporphyrins*/Coproporphyrins*/metabolism ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/metabolism

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Oct 16; Vol. 52 (11), pp. 1356-1362. Date of Electronic Publication: 2024 Oct 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes, and organic anion-transporting polypeptides (OATP1B1 and OATP2B1).

  • Authors : Dombi Á; Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary.; Kaci H

Subjects: Flavonoids*/Flavonoids*/Flavonoids*/pharmacology ; Organic Anion Transporters*/Organic Anion Transporters*/Organic Anion Transporters*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism

  • Source: Pharmacology research & perspectives [Pharmacol Res Perspect] 2024 Oct; Vol. 12 (5), pp. e70021.Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States

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Academic Journal

Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC).

  • Authors : Kastrinou-Lampou V; Pharmacokinetic Sciences, BioMedical Research, Novartis, Basel, Switzerland.; Preclinical Safety, BioMedical Research, Novartis, Basel, Switzerland.

Subjects: Cholestasis*/Cholestasis*/Cholestasis*/chemically induced ; Cholestasis*/Cholestasis*/Cholestasis*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism

  • Source: Archives of toxicology [Arch Toxicol] 2024 Oct; Vol. 98 (10), pp. 3409-3424. Date of Electronic Publication: 2024 Jul 18.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Human organic anion transporting polypeptide 1B3 (OATP1B3) is more heavily N-glycosylated than OATP1B1 in extracellular loops 2 and 5.

  • Authors : Liang T; College of Pharmaceutical Sciences, Soochow University, 199 Renai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China.; Liu H

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/metabolism ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/genetics

  • Source: International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 278 (Pt 2), pp. 134748. Date of Electronic Publication: 2024 Aug 13.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework.

  • Authors : Hartauer M; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Murphy WA

Subjects: Rifampin*/Rifampin*/Rifampin*/pharmacokinetics ; Rifampin*/Rifampin*/Rifampin*/pharmacology ; Drug Interactions*

  • Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Sep; Vol. 13 (9), pp. 1513-1527. Date of Electronic Publication: 2024 Jun 19.Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

SLCO1B1 and ABCG2 genotype-informed phenotypes are related to variation in ramipril exposure.

  • Authors : Abbes H; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.; Biochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.

Subjects: ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism ; Ramipril*/Ramipril*/Ramipril*/pharmacokinetics

  • Source: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2024 Sep; Vol. 135 (3), pp. 295-307. Date of Electronic Publication: 2024 Jul 16.Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843

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Academic Journal

The reduced function allele SLCO1B1 c.521T>C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with mycophenolic acid.

Subjects: Kidney Transplantation*/Kidney Transplantation*/Kidney Transplantation*/adverse effects ; Mycophenolic Acid*/Mycophenolic Acid*/Mycophenolic Acid*/adverse effects ; Mycophenolic Acid*/Mycophenolic Acid*/Mycophenolic Acid*/administration & dosage

  • Source: Pharmacogenetics and genomics [Pharmacogenet Genomics] 2024 Sep 01; Vol. 34 (7), pp. 226-235. Date of Electronic Publication: 2024 May 20.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101231005 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Mechanistic Account of Distinct Change in Organic Anion Transporting Polypeptide 1B (OATP1B) Substrate Pharmacokinetics during OATP1B-Mediated Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling.

  • Authors : Hegde PV; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.; Morse BL

Subjects: Drug Interactions*/Drug Interactions*/Drug Interactions*/physiology ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Jul 16; Vol. 52 (8), pp. 886-898. Date of Electronic Publication: 2024 Jul 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Effect of Strong CYP3A4 Inhibition, CYP3A4 Induction, and OATP1B1/3 Inhibition on the Pharmacokinetics of a Single Oral Dose of Sotorasib.

  • Authors : Cardona P; Clinical Pharmacology, Modeling and Simulation, Amgen Inc., Thousand Oaks, CA, USA.; Dutta S

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/antagonists & inhibitors

  • Source: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2024 Jul; Vol. 13 (7), pp. 810-818. Date of Electronic Publication: 2024 Feb 29.Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A Clinical Practice Perspective on the Evaluation of OATP1B1-associated Drug Interactions.

  • Authors : Stäuble CK; Biopharmacy, Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; Pharmaceutical Care, Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Subjects: Drug Interactions* ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Jul; Vol. 116 (1), pp. 30-33. Date of Electronic Publication: 2024 Mar 14.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Academic Journal

Mechanistic Determinants of Daprodustat Drug-Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B-CYP2C8 Interplay.

  • Authors : Bi YA; Pharmacokinetics, Dynamics, and Metabolism, Pfizer R&D, Pfizer Inc., Groton, Connecticut, USA.; Jordan S

Subjects: Cytochrome P-450 CYP2C8*/Cytochrome P-450 CYP2C8*/Cytochrome P-450 CYP2C8*/metabolism ; Drug Interactions* ; Hepatocytes*/Hepatocytes*/Hepatocytes*/metabolism

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Jun; Vol. 115 (6), pp. 1336-1345. Date of Electronic Publication: 2024 Feb 26.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Academic Journal

Physiologically Based Pharmacokinetic Model of OATP1B Substrates with a Nonlinear Mixed Effect Approach: Estimating Empirical In Vitro-to-In Vivo Scaling Factors.

  • Authors : Li R; Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, Cambridge, MA, 02139, USA. .; Kimoto E

Subjects: Models, Biological* ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Nonlinear Dynamics*

  • Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2024 Aug; Vol. 63 (8), pp. 1177-1189. Date of Electronic Publication: 2024 Aug 19.Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926

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Academic Journal

Allelic frequencies of polymorphism c.521T>C (rs4149056) favor preemptive SLCO1B1 genotyping in Armenia.

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics ; Gene Frequency* ; Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/adverse effects

  • Source: Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2024 Jul 15; Vol. 39 (3), pp. 159-161. Date of Electronic Publication: 2024 Jul 15 (Print Publication: 2024).Publisher: De Gruyter Country of Publication: Germany NLM ID: 101653409 Publication Model: eCollection Cited Medium: Internet ISSN: 2363-8915

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Academic Journal

Interactions of oleanane pentacyclic triterpenoids with human organic anion transporting polypeptide 1B1 and 1B3.

  • Authors : Tian Y; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.; Wang X

Subjects: Oleanolic Acid*/Oleanolic Acid*/Oleanolic Acid*/analogs & derivatives ; Oleanolic Acid*/Oleanolic Acid*/Oleanolic Acid*/pharmacology ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/metabolism

  • Source: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2024 Jun; Vol. 98, pp. 105842. Date of Electronic Publication: 2024 May 16.Publisher: Pergamon Press Country of Publication: England NLM ID: 8712158 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP.

  • Authors : Mykkänen AJH; Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland.; Department of Clinical Pharmacology, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland.

Subjects: Area Under Curve* ; Atorvastatin*/Atorvastatin*/Atorvastatin*/pharmacokinetics ; Atorvastatin*/Atorvastatin*/Atorvastatin*/blood

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Jun; Vol. 115 (6), pp. 1428-1440. Date of Electronic Publication: 2024 Mar 17.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Academic Journal

Rifampin- and Silymarin-Mediated Pharmacokinetic Interactions of Exogenous and Endogenous Substrates in a Transgenic OATP1B Mouse Model.

  • Authors : Bechtold BJ; Department of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States.; Lynch KD

Subjects: Rifampin*/Rifampin*/Rifampin*/pharmacokinetics ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism

  • Source: Molecular pharmaceutics [Mol Pharm] 2024 May 06; Vol. 21 (5), pp. 2284-2297. Date of Electronic Publication: 2024 Mar 26.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

SLCO1B1 Exome Sequencing and Statin Treatment Response in 64,000 UK Biobank Patients.

  • Authors : Türkmen D; Epidemiology & Public Health Group, Department of Clinical & Biomedical Science, Faculty of Health & Life Sciences, University of Exeter, Exeter EX4 4QD, UK.; Bowden J

Subjects: Exome Sequencing*/Exome Sequencing*/Exome Sequencing*/methods ; Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use ; Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/adverse effects

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 17; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Pharmacogenetic Study of Drugs Affecting Mycobacterium tuberculosis.

  • Authors : Shabani S; Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Farnia P

Subjects: Arylamine N-Acetyltransferase*/Arylamine N-Acetyltransferase*/Arylamine N-Acetyltransferase*/genetics ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics ; Antitubercular Agents*

  • Source: International journal of mycobacteriology [Int J Mycobacteriol] 2024 Apr 01; Vol. 13 (2), pp. 206-212. Date of Electronic Publication: 2024 Jun 15.Publisher: Medknow Country of Publication: India NLM ID: 101615660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-554X

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Academic Journal

Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.

  • Authors : Shan Z; Shanghai Fifth People's Hospital, Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Yang X

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/chemistry ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism; Humans

  • Source: Cell research [Cell Res] 2023 Dec; Vol. 33 (12), pp. 940-951. Date of Electronic Publication: 2023 Sep 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The impact of SLCO1B1 rs4149056 on LDL-C target achievement after lipid lowering therapy optimization in men and women with familial hypercholesterolemia.

Subjects: Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use ; Hyperlipoproteinemia Type II*/Hyperlipoproteinemia Type II*/Hyperlipoproteinemia Type II*/drug therapy ; Hyperlipoproteinemia Type II*/Hyperlipoproteinemia Type II*/Hyperlipoproteinemia Type II*/genetics

  • Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Feb 08; Vol. 15, pp. 1346152. Date of Electronic Publication: 2024 Feb 08 (Print Publication: 2024).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print

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Academic Journal

Utilizing Pharmacogenomic Data for a Safer Use of Statins among the Emirati Population.

  • Authors : Alqasrawi MN; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.; Al-Mahayri ZN

Subjects: Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use ; Polymorphism, Single Nucleotide*

  • Source: Current vascular pharmacology [Curr Vasc Pharmacol] 2024; Vol. 22 (3), pp. 218-229.Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101157208 Publication Model: Print Cited Medium: Internet

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Academic Journal

Structure of human drug transporters OATP1B1 and OATP1B3.

  • Authors : Ciută AD; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich, Switzerland.; Nosol K

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/chemistry ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/chemistry; Humans

  • Source: Nature communications [Nat Commun] 2023 Sep 18; Vol. 14 (1), pp. 5774. Date of Electronic Publication: 2023 Sep 18.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder.

  • Authors : Häkkinen K; Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio FI-70240, Finland.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki FI-00014, Finland.

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics ; Psychotic Disorders*; Humans

  • Source: Molecular pharmaceutics [Mol Pharm] 2023 Mar 06; Vol. 20 (3), pp. 1500-1508. Date of Electronic Publication: 2023 Feb 13.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population.

  • Authors : Božina T; Department of Medical Chemistry, Biochemistry, and Clinical Chemistry, University of Zagreb School of Medicine, Zagreb, Croatia.; Ganoci L

Subjects: ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics ; Neoplasm Proteins*/Neoplasm Proteins*/Neoplasm Proteins*/genetics

  • Source: Annals of human biology [Ann Hum Biol] 2022 Dec; Vol. 49 (7-8), pp. 323-331. Date of Electronic Publication: 2022 Dec 09.Publisher: Taylor & Francis Country of Publication: England NLM ID: 0404024 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Analysis of the difference in SLCO1B1 and APOE gene polymorphisms between Mongolian and Han populations.

  • Authors : Niu R; Department of Clinical Laboratory, Ordos Central Hospital, Ordos, Inner Mongolia, 017000, China.; Guo L

Subjects: Apolipoproteins E*/Apolipoproteins E*/Apolipoproteins E*/genetics ; Cardiovascular Diseases*/Cardiovascular Diseases*/Cardiovascular Diseases*/epidemiology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use

  • Source: Pharmacogenomics [Pharmacogenomics] 2022 Sep; Vol. 23 (14), pp. 783-790. Date of Electronic Publication: 2022 Sep 08.Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 100897350 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Frequency of functional exonic single-nucleotide polymorphisms and haplotype distribution in the SLCO1B1 gene across genetic ancestry groups in the Qatari population.

  • Authors : Dashti M; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Kuwait City, Kuwait.; Al-Matrouk A

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics ; Organic Anion Transporters*/Organic Anion Transporters*/Organic Anion Transporters*/genetics ; Polymorphism, Single Nucleotide*

  • Source: Scientific reports [Sci Rep] 2022 Sep 01; Vol. 12 (1), pp. 14858. Date of Electronic Publication: 2022 Sep 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid.

  • Authors : Zhang Y; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India.

Subjects: Chenodeoxycholic Acid*/Chenodeoxycholic Acid*/Chenodeoxycholic Acid*/metabolism ; Chenodeoxycholic Acid*/Chenodeoxycholic Acid*/Chenodeoxycholic Acid*/pharmacology ; Coproporphyrins*/Coproporphyrins*/Coproporphyrins*/blood

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2022 Aug; Vol. 50 (8), pp. 1077-1086. Date of Electronic Publication: 2022 May 30.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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SLCO1B1 and ABCB1 variants synergistically influence the atorvastatin treatment response in South Indian coronary artery disease patients.

  • Authors : Bharath G; Department of Genetics, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600113, India.; Vishnuprabu DP

Subjects: ATP Binding Cassette Transporter, Subfamily B*/ATP Binding Cassette Transporter, Subfamily B*/ATP Binding Cassette Transporter, Subfamily B*/genetics ; Atorvastatin*/Atorvastatin*/Atorvastatin*/therapeutic use ; Coronary Artery Disease*/Coronary Artery Disease*/Coronary Artery Disease*/drug therapy

  • Source: Pharmacogenomics [Pharmacogenomics] 2022 Aug; Vol. 23 (12), pp. 683-694. Date of Electronic Publication: 2022 Aug 15.Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 100897350 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Biomarker-Informed Model-Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug-Drug Interactions.

  • Authors : Kimoto E; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer Inc, Groton, Connecticut, USA.; Costales C

Subjects: Models, Biological*; Atorvastatin/Atorvastatin/Atorvastatin/*pharmacokinetics ; Coproporphyrins/Coproporphyrins/Coproporphyrins/*blood

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Feb; Vol. 111 (2), pp. 404-415. Date of Electronic Publication: 2021 Oct 22.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1.

  • Authors : Chen J; College of Life Sciences, South China Agricultural University, Guangzhou, China.; Xue Y

Subjects: Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors ; Plant Extracts/Plant Extracts/Plant Extracts/*pharmacology ; Tripterygium/Tripterygium/Tripterygium/*chemistry

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Jan 15; Vol. 435, pp. 115848. Date of Electronic Publication: 2021 Dec 24.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model.

  • Authors : Taylor ZL; Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, Ohio, USA.; Division of Research in Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Subjects: Liver-Specific Organic Anion Transporter 1* ; Mice, Knockout* ; Pharmacogenomic Testing*

  • Source: Clinical and translational science [Clin Transl Sci] 2021 Nov; Vol. 14 (6), pp. 2267-2277. Date of Electronic Publication: 2021 Jun 30.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet

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The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality.

  • Authors : Kiander W; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, 00014, Helsinki, Finland.; Vellonen KS

Subjects: Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/*metabolism ; Isoquinolines/Isoquinolines/Isoquinolines/*metabolism ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism

  • Source: Pharmaceutical research [Pharm Res] 2021 Oct; Vol. 38 (10), pp. 1663-1675. Date of Electronic Publication: 2021 Oct 13.Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium:

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OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma.

  • Authors : Wen J; Department of GCP, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.; Zhao M

Subjects: Mutation*; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*drug therapy ; Liver Neoplasms/Liver Neoplasms/Liver Neoplasms/*drug therapy

  • Source: Disease markers [Dis Markers] 2021 Sep 26; Vol. 2021, pp. 9711179. Date of Electronic Publication: 2021 Sep 26 (Print Publication: 2021).Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: eCollection Cited Medium: Internet ISSN:

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Prevalence of dyslipidemia and gene polymorphisms of ABCB1 and SLCO1B1 in Han, Uygur, Kazak, Hui, Tatar, Kirgiz, and Sibe populations with coronary heart disease in Xinjiang, China.

  • Authors : Wang T; Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.; Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.

Subjects: Coronary Disease/Coronary Disease/Coronary Disease/*blood ; Coronary Disease/Coronary Disease/Coronary Disease/*genetics ; Dyslipidemias/Dyslipidemias/Dyslipidemias/*blood

  • Source: Lipids in health and disease [Lipids Health Dis] 2021 Sep 25; Vol. 20 (1), pp. 116. Date of Electronic Publication: 2021 Sep 25.Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X

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Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics.

  • Authors : Ambrus C; SOLVO Biotechnology, Irinyi József street 4-20, 1117, Budapest, Hungary.; Doctoral School of Molecular Medicine, Semmelweis University, Tűzoltó u. 37-47, 1094, Budapest, Hungary.

Subjects: ATP Binding Cassette Transporter, Subfamily B, Member 11/ATP Binding Cassette Transporter, Subfamily B, Member 11/ATP Binding Cassette Transporter, Subfamily B, Member 11/*metabolism ; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Liver/Liver/Liver/*drug effects

  • Source: Scientific reports [Sci Rep] 2021 Sep 08; Vol. 11 (1), pp. 17810. Date of Electronic Publication: 2021 Sep 08.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Organic Anion Transporting Polypeptide 1B1 Is a Potential Reporter for Dual MR and Optical Imaging.

  • Authors : Lee YH; Department of Medical Imaging, Taipei TzuChi General Hospital, Buddhist Tzu-Chi Medical Foundation, New Taipei City 23142, Taiwan.; Wu MR

Subjects: Gadolinium DTPA/Gadolinium DTPA/Gadolinium DTPA/*chemistry ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism ; Meglumine/Meglumine/Meglumine/*analogs & derivatives

  • Source: International journal of molecular sciences [Int J Mol Sci] 2021 Aug 16; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Relationship of hemoglobin level and plasma coproporphyrin-I concentrations as an endogenous probe for phenotyping OATP1B.

  • Authors : Suzuki Y; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Kiyose, Japan.; Sasamoto Y

Subjects: Coproporphyrins/Coproporphyrins/Coproporphyrins/*blood ; Hemoglobins/Hemoglobins/Hemoglobins/*analysis ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*genetics

  • Source: Clinical and translational science [Clin Transl Sci] 2021 Jul; Vol. 14 (4), pp. 1403-1411. Date of Electronic Publication: 2021 May 07.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet

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Regulatory guidelines do not accurately predict tolvaptan and metabolite interactions at BCRP, OATP1B1, and OAT3 transporters.

  • Authors : Shoaf SE; Quantitative Pharmacology, Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA.; Bricmont P

Subjects: ATP Binding Cassette Transporter, Subfamily G, Member 2/ATP Binding Cassette Transporter, Subfamily G, Member 2/ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors ; Drug Approval/Drug Approval/Drug Approval/*statistics & numerical data ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors

  • Source: Clinical and translational science [Clin Transl Sci] 2021 Jul; Vol. 14 (4), pp. 1535-1542. Date of Electronic Publication: 2021 Apr 09.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet

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Identification of Glycochenodeoxycholate 3-O-Glucuronide and Glycodeoxycholate 3-O-Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers.

  • Authors : Neuvonen M; Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland.; HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland.

Subjects: Glucuronides/Glucuronides/Glucuronides/*metabolism ; Glycochenodeoxycholic Acid/Glycochenodeoxycholic Acid/Glycochenodeoxycholic Acid/*metabolism ; Liver/Liver/Liver/*metabolism

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Mar; Vol. 109 (3), pp. 646-657. Date of Electronic Publication: 2020 Oct 18.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Leucine heptad motifs within transmembrane domains affect function and oligomerization of human organic anion transporting polypeptide 1B1.

  • Authors : Ni C; College of Life Sciences, South China Agricultural University, Guangzhou, China.; Wang X

Subjects: Protein Multimerization*; Cell Membrane/Cell Membrane/Cell Membrane/*metabolism ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism

  • Source: Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2021 Apr 01; Vol. 1863 (4), pp. 183554. Date of Electronic Publication: 2021 Jan 08.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731713 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Proteomics-Informed Prediction of Rosuvastatin Plasma Profiles in Patients With a Wide Range of Body Weight.

  • Authors : Wegler C; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; DMPK, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Subjects: Body Weight* ; Proteomics*; Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/*blood

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Mar; Vol. 109 (3), pp. 762-771. Date of Electronic Publication: 2020 Oct 18.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients.

  • Authors : Masuo Y; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.; Fujita KI

Subjects: Hepatocytes/Hepatocytes/Hepatocytes/*drug effects ; Indoles/Indoles/Indoles/*pharmacology ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors

  • Source: Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2020 Dec; Vol. 35 (6), pp. 555-562. Date of Electronic Publication: 2020 Sep 19.Publisher: Elsevier Country of Publication: England NLM ID: 101164773 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-0920

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Coproporphyrin I Can Serve as an Endogenous Biomarker for OATP1B1 Inhibition: Assessment Using a Glecaprevir/Pibrentasvir Clinical Study.

  • Authors : Kalluri HV; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.; Kikuchi R

Subjects: Benzimidazoles/Benzimidazoles/Benzimidazoles/*pharmacokinetics ; Biomarkers, Pharmacological/Biomarkers, Pharmacological/Biomarkers, Pharmacological/*blood ; Coproporphyrins/Coproporphyrins/Coproporphyrins/*blood

  • Source: Clinical and translational science [Clin Transl Sci] 2021 Jan; Vol. 14 (1), pp. 373-381. Date of Electronic Publication: 2020 Oct 24.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet

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Substantially Increased Plasma Coproporphyrin-I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population.

  • Authors : Suzuki Y; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Tokyo, Japan.; Sasamoto Y

Subjects: Biomarkers, Pharmacological/Biomarkers, Pharmacological/Biomarkers, Pharmacological/*blood ; Coproporphyrins/Coproporphyrins/Coproporphyrins/*blood ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*genetics

  • Source: Clinical and translational science [Clin Transl Sci] 2021 Jan; Vol. 14 (1), pp. 382-388. Date of Electronic Publication: 2020 Oct 05.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet

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