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Academic Journal

Stage-Dependent Fibrotic Gene Profiling of WISP1-Mediated Fibrogenesis in Human Fibroblasts.

  • Authors : Singh K; Biotherapeutics Enabling Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46225, USA.; Witek M

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; Fibroblasts*/Fibroblasts*/Fibroblasts*/metabolism

  • Source: Cells [Cells] 2024 Dec 05; Vol. 13 (23). Date of Electronic Publication: 2024 Dec 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

The TGF-β1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects.

  • Authors : Dropmann A; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.; Alex S

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; Liver Cirrhosis*/Liver Cirrhosis*/Liver Cirrhosis*/genetics

  • Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 05; Vol. 732, pp. 150409. Date of Electronic Publication: 2024 Jul 16.Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

CCN6 Suppresses Metaplastic Breast Carcinoma by Antagonizing Wnt/β-Catenin Signaling to Inhibit EZH2-Driven EMT.

  • Authors : Gonzalez ME; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.

Subjects: Enhancer of Zeste Homolog 2 Protein*/Enhancer of Zeste Homolog 2 Protein*/Enhancer of Zeste Homolog 2 Protein*/metabolism ; Enhancer of Zeste Homolog 2 Protein*/Enhancer of Zeste Homolog 2 Protein*/Enhancer of Zeste Homolog 2 Protein*/genetics ; Enhancer of Zeste Homolog 2 Protein*/Enhancer of Zeste Homolog 2 Protein*/Enhancer of Zeste Homolog 2 Protein*/antagonists & inhibitors

  • Source: Cancer research [Cancer Res] 2024 Oct 01; Vol. 84 (19), pp. 3235-3249.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium:

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Academic Journal

Normalization of WISP1 circulating level and tissue expression following metabolic and bariatric surgery using rat model.

  • Authors : Kitaghenda FK; Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China.; Wang J

Subjects: Rats, Sprague-Dawley* ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; Bariatric Surgery*/Bariatric Surgery*/Bariatric Surgery*/methods

  • Source: Updates in surgery [Updates Surg] 2024 Dec; Vol. 76 (8), pp. 2841-2849. Date of Electronic Publication: 2024 Oct 15.Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 101539818 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

First copy number variant in trans with single nucleotide variant in CCN6 causing progressive pseudorheumatoid dysplasia revealed by genome sequencing and deep phenotyping in monozygotic twins.

Subjects: DNA Copy Number Variations*/DNA Copy Number Variations*/DNA Copy Number Variations*/genetics ; Phenotype* ; Twins, Monozygotic*/Twins, Monozygotic*/Twins, Monozygotic*/genetics Arthropathy, progressive pseudorheumatoid, of childhood

  • Source: American journal of medical genetics. Part A [Am J Med Genet A] 2024 Nov; Vol. 194 (11), pp. e63801. Date of Electronic Publication: 2024 Jul 03.Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101235741 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Progressive pseudorheumatoid dysplasia involving a novel CCN6 mutation: a case report.

  • Authors : Li Y; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.; Huang Z

Subjects: Mutation* ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics; Humans Arthropathy, progressive pseudorheumatoid, of childhood

  • Source: Frontiers in immunology [Front Immunol] 2024 Oct 30; Vol. 15, pp. 1445420. Date of Electronic Publication: 2024 Oct 30 (Print Publication: 2024).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Unlocking the therapeutic potential of WISP-1: A comprehensive exploration of its role in age-related musculoskeletal disorders.

  • Authors : Lu W; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; Musculoskeletal Diseases*/Musculoskeletal Diseases*/Musculoskeletal Diseases*/therapy

  • Source: International immunopharmacology [Int Immunopharmacol] 2025 Jan 03; Vol. 145, pp. 113791. Date of Electronic Publication: 2024 Dec 11.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Role of WISP1 in Stellate Cell Migration and Liver Fibrosis.

  • Authors : González D; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.; Campos G

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; Hepatic Stellate Cells*/Hepatic Stellate Cells*/Hepatic Stellate Cells*/metabolism

  • Source: Cells [Cells] 2024 Sep 29; Vol. 13 (19). Date of Electronic Publication: 2024 Sep 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Multi-omics Analysis Revealed that the CCN Family Regulates Cell Crosstalk, Extracellular Matrix, and Immune Escape, Leading to a Poor Prognosis of Glioma.

  • Authors : Gu J; Department of Neurosurgery, Shanghai General Hospital affiliated to Nanjing Medical University, Shanghai, China.; Department of Neurosurgery, Shanghai General Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Subjects: Glioma*/Glioma*/Glioma*/metabolism ; Glioma*/Glioma*/Glioma*/pathology ; Glioma*/Glioma*/Glioma*/genetics

  • Source: Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Sep; Vol. 82 (3), pp. 2157-2170. Date of Electronic Publication: 2024 Jun 05.Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

WISP1 and Macrophage Migration Inhibitory Factor in Respiratory Inflammation: Novel Insights and Therapeutic Potentials for Asthma and COPD.

  • Authors : Christopoulou ME; Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece.; Clinic of Pneumology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Subjects: Pulmonary Disease, Chronic Obstructive*/Pulmonary Disease, Chronic Obstructive*/Pulmonary Disease, Chronic Obstructive*/metabolism ; Pulmonary Disease, Chronic Obstructive*/Pulmonary Disease, Chronic Obstructive*/Pulmonary Disease, Chronic Obstructive*/immunology ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 18; Vol. 25 (18). Date of Electronic Publication: 2024 Sep 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

An overview of CCN4 (WISP1) role in human diseases.

  • Authors : Singh K; Biotherapeutic Enabling Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46225, USA.; Oladipupo SS

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics; Animals

  • Source: Journal of translational medicine [J Transl Med] 2024 Jun 27; Vol. 22 (1), pp. 601. Date of Electronic Publication: 2024 Jun 27.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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Academic Journal

Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling.

  • Authors : Song MH; College of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.; Yoo J

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; Fibrosis*

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 06; Vol. 25 (11). Date of Electronic Publication: 2024 Jun 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts' Activation and Collagen Processing.

  • Authors : Li Z; Translational Health Sciences, Bristol Medical School, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.; Williams H

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; Fibroblasts*/Fibroblasts*/Fibroblasts*/metabolism

  • Source: Cells [Cells] 2024 Jun 06; Vol. 13 (11). Date of Electronic Publication: 2024 Jun 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Silencing of METTL3 prevents the proliferation, migration, epithelial-mesenchymal transition, and renal fibrosis of high glucose-induced HK2 cells by mediating WISP1 in m6A-dependent manner.

  • Authors : Chen Y; Department of Nephrology, Shenzhen Guangming District People’s Hospital, Guangming, Shenzhen 518000, China.; Li P

Subjects: Diabetic Nephropathies*/Diabetic Nephropathies*/Diabetic Nephropathies*/genetics ; Diabetic Nephropathies*/Diabetic Nephropathies*/Diabetic Nephropathies*/metabolism ; Epithelial-Mesenchymal Transition*

  • Source: Aging [Aging (Albany NY)] 2024 Jan 29; Vol. 16 (2), pp. 1237-1248. Date of Electronic Publication: 2024 Jan 29.Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6.

  • Authors : Zhao Y; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Department of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Subjects: Carcinogenesis* ; Cell Transformation, Neoplastic* ; Deubiquitinating Enzymes*/Deubiquitinating Enzymes*/Deubiquitinating Enzymes*/metabolism

  • Source: Clinical and translational medicine [Clin Transl Med] 2023 Aug; Vol. 13 (8), pp. e1385.Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326

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Academic Journal

The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility.

Subjects: Drosophila*/Drosophila*/Drosophila*/metabolism ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/chemistry ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism

  • Source: Genetics [Genetics] 2023 Mar 02; Vol. 223 (3).Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Analysis of CCN4/WISP1 Effects on Joint Tissues Using Gain- and Loss-of-Function Approaches.

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; Osteoarthritis*/Osteoarthritis*/Osteoarthritis*/genetics

  • Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2582, pp. 369-390.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Academic Journal

CCN Proteins (Cellular Communication Network Factors): Expanding Their Repertoire Toward a New Concept.

  • Authors : Takigawa M; Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School/Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. .

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; Cell Communication*

  • Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2582, pp. 1-10.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Academic Journal

Cellular Fluorescence Imaging for the Evaluation of Bioactivity of CCN Family Proteins.

  • Authors : Kawaki H; Department of Chemistry, Asahi University School of Dentistry, Gifu, Japan. .; Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. .

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; Optical Imaging*

  • Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2582, pp. 23-29.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Academic Journal

Protocols for Screening Peptides Binding to CCN Family Proteins and Their Extended Utility.

  • Authors : Kubota S; Department of Biochemistry and Molecular Dentistry, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. .; Kawaki H

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; Bacteriophages*/Bacteriophages*/Bacteriophages*/genetics

  • Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2582, pp. 87-101.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Academic Journal

Optimal CCN4 Immunofluorescence for Tissue Microarray.

  • Authors : Gaudreau PO; Department of Oncology, Queen's University and Canadian Cancer Trials Group, Kingston, ON, Canada. .; Cousineau I

Subjects: CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/metabolism ; Neoplasms*

  • Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2582, pp. 13-21.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Academic Journal

CCN6 influences transcription and controls mitochondrial mass and muscle organization.

  • Authors : Ganguly A; Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.; Padhan DK

Subjects: RNA Polymerase II* ; Zebrafish*/Zebrafish*/Zebrafish*/genetics ; Zebrafish Proteins*/Zebrafish Proteins*/Zebrafish Proteins*/genetics

  • Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2023 Mar; Vol. 37 (3), pp. e22815.Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited

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Academic Journal

Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia.

  • Authors : Zhang H; Department of Hematology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China; Institute of Blood and Marrow Transplantation, Jining Medical University, Jining, Shandong, China.

Subjects: Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/genetics ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics ; Repressor Proteins*/Repressor Proteins*/Repressor Proteins*/genetics

  • Source: The Journal of biological chemistry [J Biol Chem] 2023 Mar; Vol. 299 (3), pp. 102971. Date of Electronic Publication: 2023 Feb 01.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

CCN6 improves hepatic steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis.

  • Authors : Song Y; Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.; Li C

Subjects: Non-alcoholic Fatty Liver Disease*/Non-alcoholic Fatty Liver Disease*/Non-alcoholic Fatty Liver Disease*/pathology ; CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/CCN Intercellular Signaling Proteins*/genetics; Animals

  • Source: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2023 Feb; Vol. 43 (2), pp. 357-369. Date of Electronic Publication: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101160857 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

HuR-dependent expression of Wisp1 is necessary for TGFβ-induced cardiac myofibroblast activity.

  • Authors : Green LC; Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America; Department of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.

Subjects: Myofibroblasts*/Myofibroblasts*/Myofibroblasts*/metabolism ; Transforming Growth Factor beta*/Transforming Growth Factor beta*/Transforming Growth Factor beta*/metabolism ; ELAV-Like Protein 1*/ELAV-Like Protein 1*/ELAV-Like Protein 1*/metabolism

  • Source: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2023 Jan; Vol. 174, pp. 38-46. Date of Electronic Publication: 2022 Nov 11.Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-25 of  1,042 results for ""CCN Intercellular Signaling Proteins""