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Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC.

• Authors : Pieper, Nadja M.; Schnell, Julia; Bruecher, Daniela

• Source: Cell Communication and Signaling. August 27, 2024, Vol. 22 Issue 1.

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DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of [alpha]-synuclein toxicity and oligomerization.

• Authors : Popova, Blagovesta; Wang, Dan; Pätz, Christina

• Source: PLoS Genetics. March 3, 2021, Vol. 17 Issue 3, e1009407.

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Merck KGaA, Darmstadt, Germany, Builds on Leadership in Head and Neck Cancer Through Worldwide Licensing Agreement with Debiopharm for Pivotal-Stage Xevinapant; - Xevinapant is the first Inhibitor of Apoptosis Proteins antagonist with FDA Breakthrough Therapy Designation for previously untreated locally advanced squamous cell carcinoma of the head and neck, in combination with current standard of care; - A Phase II trial reported that xevinapant plus chemoradiotherapy reduced risk of death by 51% vs standard of care in this patient population; Phase III TrilynX study initiated in September 2020

• Source: PR Newswire (USA), March 1, 2021, 5pp

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Debiopharm International SA announces dosing of first patient in a combination trial of Debio 1143 and avelumab in patients with solid tumours including non-small cell lung cancer (NSCLC).

• Source: Chemical Business NewsBase (UK), November 6, 2017, 1pp

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ADAM15 Adds to Apoptosis Resistance of Synovial Fibroblasts by Modulating Focal Adhesion Kinase Signaling.

• Authors : Böhm, Beate B.; Freund, Isabell; Krause, Kristin

Subjects: FIBROBLASTS; SYNOVIAL fluid; ACADEMIC medical centersGERMANY

• Source: Arthritis & Rheumatism; Nov2013, Vol. 65 Issue 11, p2826-2834, 9p

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128th Congress of the German Society of Surgery.

Subjects: CONFERENCES & conventions; SURGERYGERMANY

• Source: Langenbeck's Archives of Surgery; Apr2011, Vol. 396 Issue 4, p551-583, 33p

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XXXI. Annual Meeting of the ADF.

Subjects: CONFERENCES & conventions; IMMUNE system; LYMPHOID tissueBERLIN (Germany); GERMANY

• Source: Archives of Dermatological Research; Feb2004, Vol. 295 Issue 8/9, p320-407, 88p

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Merck KGaA pens $1B upfront, biobucks pact with Debiopharm for next-gen cancer asset.

• Authors : Adams, Ben

Subjects: SQUAMOUS cell carcinoma; ASSETS (Accounting)GERMANY

• Source: FierceBiotech; 3/1/2021, pN.PAG-N.PAG, 1p

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Genetic expressions and evaluation of insecticidal activity of some essential oil and methomyl lannate 90% against Spodopterafrugiperda.

• Authors : Sadek, Hanaa E.; Elbehery, Huda H.; Mohamed, Shereen Abdel-Hameed

• Source: Bulletin of the National Research Centre. December, 2024, Vol. 48 Issue 1.

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PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

• Authors : Saita, Shotaro; Nolte, Hendrik; Fiedler, Kai Uwe

• Source: Nature Cell Biology. April, 2017, Vol. 19 Issue 4, p318, 11 p.

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