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Academic Journal

Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1α/β-mediated adaptive stress response pathway in skeletal muscle cells.

  • Authors : Liu P; BESE Division, KAUST Environmental Epigenetics Program, King Abdullah University Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.; Shuaib M

Subjects: Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects ; Signal Transduction*; Nedd4 Ubiquitin Protein Ligases/Nedd4 Ubiquitin Protein Ligases/Nedd4 Ubiquitin Protein Ligases/*metabolism

  • Source: Epigenetics & chromatin [Epigenetics Chromatin] 2019 Dec 19; Vol. 12 (1), pp. 78. Date of Electronic Publication: 2019 Dec 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101471619 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8935

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Academic Journal

The HECT family of E3 ubiquitin ligases: multiple players in cancer development.

  • Authors : Bernassola F; Department of Experimental Medicine and Biochemical Sciences, Biochemistry IDI-IRCCS Laboratory, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.; Karin M

Subjects: Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects ; Signal Transduction*/Signal Transduction*/Signal Transduction*/genetics; Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/*metabolism

  • Source: Cancer cell [Cancer Cell] 2008 Jul 08; Vol. 14 (1), pp. 10-21.Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686

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Academic Journal

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

  • Authors : Kamura T; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.; Maenaka K

Subjects: Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*metabolism ; Cullin Proteins/Cullin Proteins/Cullin Proteins/*metabolism ; Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/*metabolism

  • Source: Genes & development [Genes Dev] 2004 Dec 15; Vol. 18 (24), pp. 3055-65.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print Cited Medium: Print

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Academic Journal

Roles of SCF and VHL ubiquitin ligases in regulation of cell growth.

  • Authors : Kamura T; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.; Conaway JW

Subjects: Tumor Suppressor Proteins* ; Ubiquitin-Protein Ligases*; Cell Division/Cell Division/Cell Division/*physiology

  • Source: Progress in molecular and subcellular biology [Prog Mol Subcell Biol] 2002; Vol. 29, pp. 1-15.Publisher: Springer-Verlag Country of Publication: United States NLM ID: 0233223 Publication Model: Print Cited Medium: Print ISSN: 0079-6484

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Academic Journal

Genetic diagnosis in Sudanese and Tunisian families with syndromic intellectual disability through exome sequencing.

  • Authors : Yahia A; Department of Biochemistry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.; Department of Biochemistry, Faculty of Medicine, National University, Khartoum, Sudan.

Subjects: Adenosine Deaminase*/Adenosine Deaminase*/Adenosine Deaminase*/genetics ; Intellectual Disability*/Intellectual Disability*/Intellectual Disability*/diagnosis ; RNA-Binding Proteins*/RNA-Binding Proteins*/RNA-Binding Proteins*/genetics

  • Source: Annals of human genetics [Ann Hum Genet] 2022 Jul; Vol. 86 (4), pp. 181-194. Date of Electronic Publication: 2022 Feb 03.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0416661 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Tobramycin suppresses HUWE1 degradation to control MCL-1 stability during tumour development.

  • Authors : He J; Joint Laboratory for Reproductive Medicine, SCU-CUHK, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Department of Obstetrics and Gynecology, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.; Reproductive Endocrinology and Regulation Joint Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*drug effects ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

  • Source: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2020 Sep; Vol. 47 (9), pp. 1600-1610. Date of Electronic Publication: 2020 Jun 01.Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0425076 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma.

  • Authors : Crawford LJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK. .; Campbell DC

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Lenalidomide/Lenalidomide/Lenalidomide/*pharmacology ; Multiple Myeloma/Multiple Myeloma/Multiple Myeloma/*drug therapy

  • Source: Oncogene [Oncogene] 2020 Jul; Vol. 39 (27), pp. 5001-5014. Date of Electronic Publication: 2020 Jun 10.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2.

  • Authors : Yang YL; Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Breast Surgery, Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Subjects: Oncogenes*; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*metabolism ; Carrier Proteins/Carrier Proteins/Carrier Proteins/*metabolism

  • Source: Cell death and differentiation [Cell Death Differ] 2020 Mar; Vol. 27 (3), pp. 1105-1118. Date of Electronic Publication: 2019 Aug 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination.

  • Authors : Zhu Q; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.; Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA.

Subjects: Homologous Recombination* ; Ubiquitination*; BRCA1 Protein/BRCA1 Protein/BRCA1 Protein/*metabolism

  • Source: Nature communications [Nat Commun] 2021 Nov 17; Vol. 12 (1), pp. 6653. Date of Electronic Publication: 2021 Nov 17.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Report

Response to PARP Inhibition in BARD1 -Mutated Refractory Neuroblastoma.

Subjects: Neuroblastoma*/Neuroblastoma*/Neuroblastoma*/genetics ; Neuroblastoma*/Neuroblastoma*/Neuroblastoma*/pathology ; Neuroblastoma*/Neuroblastoma*/Neuroblastoma*/therapy

  • Source: The New England journal of medicine [N Engl J Med] 2024 Aug 15; Vol. 391 (7), pp. 659-661.Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  1,076 results for ""UBIQUITIN ligases""