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Academic Journal

Listen to what the animals say: a systematic review and meta-analysis of sterol 14-demethylase inhibitor efficacy for in vivo models of Trypanosoma cruzi infection.

  • Authors : Bisio MMC; Instituto Nacional de Parasitología (INP) 'Dr. Mario Fatala Chaben'-ANLIS 'Dr. Carlos G. Malbrán', Buenos Aires, Argentina. Av. Paseo Colón 568, C1097, Buenos Aires, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Subjects: 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/therapeutic use ; Chagas Disease*/Chagas Disease*/Chagas Disease*/drug therapy

  • Source: Parasitology research [Parasitol Res] 2024 Jun 21; Vol. 123 (6), pp. 248. Date of Electronic Publication: 2024 Jun 21.Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Planning new Trypanosoma cruzi CYP51 inhibitors using QSAR studies.

  • Authors : de Oliveira PIC; Programa de Pós-Graduação em Bioinformática, Faculdade de Farmácia, Universidade Federal do Rio Grande do Norte, UFRN, Rua Gen. Gustavo Cordeiro de Faria, S/N - Petrópolis, Natal, RN, 59012-570, Brazil.; de Santana Miranda PH

Subjects: Quantitative Structure-Activity Relationship* ; Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/drug effects ; Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/enzymology

  • Source: Molecular diversity [Mol Divers] 2021 Nov; Vol. 25 (4), pp. 2219-2235. Date of Electronic Publication: 2020 Jun 16.Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.

  • Authors : Friggeri L; Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.; Hargrove TY

Subjects: Drug Design*; 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*chemistry ; 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2018 Dec 13; Vol. 61 (23), pp. 10910-10921. Date of Electronic Publication: 2018 Nov 30.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*administration & dosage ; Chagas Disease/Chagas Disease/Chagas Disease/*drug therapy ; Nitroimidazoles/Nitroimidazoles/Nitroimidazoles/*administration & dosage

  • Source: ACS infectious diseases [ACS Infect Dis] 2019 Mar 08; Vol. 5 (3), pp. 365-371. Date of Electronic Publication: 2019 Jan 23.Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.

  • Authors : Calvet CM; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.; Cellular Ultra-Structure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil.

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*therapeutic use ; Chagas Disease/Chagas Disease/Chagas Disease/*drug therapy ; Parasitemia/Parasitemia/Parasitemia/*drug therapy

  • Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2017 Dec 27; Vol. 11 (12), pp. e0006132. Date of Electronic Publication: 2017 Dec 27 (Print Publication: 2017).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.

  • Authors : Franco CH; Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, Brazil; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

Subjects: Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/drug effects ; Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/genetics ; Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/growth & development

  • Source: International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2020 Aug; Vol. 13, pp. 107-120. Date of Electronic Publication: 2020 Jun 13.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101576715 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.

  • Authors : Guedes-da-Silva FH; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.; Batista DG

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*pharmacology ; Chagas Disease/Chagas Disease/Chagas Disease/*drug therapy ; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*chemistry

  • Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Mar 24; Vol. 61 (4). Date of Electronic Publication: 2017 Mar 24 (Print Publication: 2017).Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium:

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Academic Journal

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.

  • Authors : Russell S; School of Chemistry and Biochemistry, The University of Western Australia , 35 Stirling Highway, Crawley, Perth 6009, Western Australia, Australia.; Rahmani R

Subjects: Drug Discovery*; 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*pharmacology ; Trypanocidal Agents/Trypanocidal Agents/Trypanocidal Agents/*pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2016 Nov 10; Vol. 59 (21), pp. 9686-9720. Date of Electronic Publication: 2016 Sep 19.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi.

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*pharmacology ; Pyridines/Pyridines/Pyridines/*pharmacology ; Sterol 14-Demethylase/Sterol 14-Demethylase/Sterol 14-Demethylase/*chemistry

  • Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Dec 07; Vol. 60 (2), pp. 1058-66. Date of Electronic Publication: 2015 Dec 07 (Print Publication: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium:

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Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease.

  • Authors : Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.; Brand S

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*isolation & purification ; Antiprotozoal Agents/Antiprotozoal Agents/Antiprotozoal Agents/*isolation & purification ; Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/*methods

  • Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2015 Sep 22; Vol. 9 (9), pp. e0004014. Date of Electronic Publication: 2015 Sep 22 (Print Publication: 2015).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

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  • 1-10 of  25 results for ""14-alpha Demethylase Inhibitors""