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Academic Journal

Inhibition of the all-trans Retinoic Acid ( at RA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous at RA Signaling.

  • Authors : Stevison F; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (F.S., S.T., N.I.); and School of Molecular Biosciences and the Center for Reproductive Biology, Washington State University, Pullman, Washington (C.H., T.K.).

Subjects: Benzothiazoles/Benzothiazoles/Benzothiazoles/*pharmacology ; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*pharmacology ; Retinoic Acid 4-Hydroxylase/Retinoic Acid 4-Hydroxylase/Retinoic Acid 4-Hydroxylase/*antagonists & inhibitors

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2017 Jul; Vol. 45 (7), pp. 846-854. Date of Electronic Publication: 2017 Apr 26.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Molecular recognition of CYP26A1 binding pockets and structure-activity relationship studies for design of potent and selective retinoic acid metabolism blocking agents.

  • Authors : Sun B; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China.; Song S

Subjects: Azoles/Azoles/Azoles/*chemistry ; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*chemistry ; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*chemistry

  • Source: Journal of molecular graphics & modelling [J Mol Graph Model] 2015 Mar; Vol. 56, pp. 10-9. Date of Electronic Publication: 2014 Dec 08.Publisher: Elsevier Science, Inc Country of Publication: United States NLM ID: 9716237 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Nitric oxide and interleukin-1β stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes.

  • Authors : Lee CM; Department of Pharmacology, Emory University, Atlanta, Georgia (C.-m.L., B.-s.L., E.T.M.); and Department of Pharmaceutics, University of Washington, Seattle, Washington (S.L.A., N.I.).

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Down-Regulation/Down-Regulation/Down-Regulation/*physiology ; Hepatocytes/Hepatocytes/Hepatocytes/*enzymology

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2014 Jan; Vol. 348 (1), pp. 141-52. Date of Electronic Publication: 2013 Oct 21.Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

2-(2-Methylfuran-3-carboxamido)-3-phenylpropanoic acid, a potential CYP26A1 inhibitor to enhance all-trans retinoic acid-induced leukemia cell differentiation based on virtual screening and biological evaluation.

  • Authors : Li F; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China.; Zhao D

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2013 Jun 01; Vol. 21 (11), pp. 3256-61. Date of Electronic Publication: 2013 Apr 03.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.

  • Authors : Takeuchi H; Laboratory of Biodefense Research, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Japan. ; Yokota A

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*physiology ; Signal Transduction/Signal Transduction/Signal Transduction/*drug effects

  • Source: PloS one [PLoS One] 2011 Jan 07; Vol. 6 (1), pp. e16089. Date of Electronic Publication: 2011 Jan 07.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic Cited Medium: Internet

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Academic Journal

The CYP26 inhibitor R115866 potentiates the effects of all-trans retinoic acid on cultured human epidermal keratinocytes.

  • Authors : Giltaire S; Cell and Tissue Laboratory, URPHYM, University of Namur (FUNDP), 61 rue de Bruxelles, B-5000 Namur, Belgium.; Herphelin F

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Benzothiazoles/Benzothiazoles/Benzothiazoles/*pharmacology ; Epidermis/Epidermis/Epidermis/*drug effects

  • Source: The British journal of dermatology [Br J Dermatol] 2009 Mar; Vol. 160 (3), pp. 505-13. Date of Electronic Publication: 2008 Dec 11.Publisher: Oxford University Press Country of Publication: England NLM ID: 0004041 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Talarozole, a selective inhibitor of P450-mediated all-trans retinoic acid for the treatment of psoriasis and acne.

  • Authors : Geria AN; University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07101, USA. ; Scheinfeld NS

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Acne Vulgaris/Acne Vulgaris/Acne Vulgaris/*drug therapy ; Benzothiazoles/Benzothiazoles/Benzothiazoles/*therapeutic use

  • Source: Current opinion in investigational drugs (London, England : 2000) [Curr Opin Investig Drugs] 2008 Nov; Vol. 9 (11), pp. 1228-37.Publisher: Thomson Reuters (Scientific) Ltd Country of Publication: England NLM ID: 100965718 Publication Model: Print Cited Medium: Print ISSN:

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Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells.

  • Authors : Gomaa MS; Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.; Armstrong JL

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Amines/Amines/Amines/*pharmacology ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 Sep 01; Vol. 16 (17), pp. 8301-13. Date of Electronic Publication: 2007 Jun 29.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.

  • Authors : Armstrong JL; Newcastle University, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.; Taylor GA

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Benzothiazoles/Benzothiazoles/Benzothiazoles/*pharmacology ; Imidazoles/Imidazoles/Imidazoles/*pharmacology

  • Source: British journal of cancer [Br J Cancer] 2007 Jun 04; Vol. 96 (11), pp. 1675-83. Date of Electronic Publication: 2007 May 08.Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited

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Academic Journal

Prospective teratology of retinoic acid metabolic blocking agents (RAMBAs) and loss of CYP26 activity.

  • Authors : McCaffery P; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. ; Simons C

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Abnormalities, Drug-Induced/Abnormalities, Drug-Induced/Abnormalities, Drug-Induced/*metabolism ; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*metabolism

  • Source: Current pharmaceutical design [Curr Pharm Des] 2007; Vol. 13 (29), pp. 3020-37.Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9602487 Publication Model: Print Cited Medium: Internet

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  • 1-10 of  57 results for ""Cytochrome P-450 Enzyme Inhibitors""