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Academic Journal

Enhancing the Predictive Power of Machine Learning Models through a Chemical Space Complementary DEL Screening Strategy.

  • Authors : Suo Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.

Subjects: Machine Learning* ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/chemistry ; Transcription Factors*/Transcription Factors*/Transcription Factors*/metabolism

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 18969-18980. Date of Electronic Publication: 2024 Oct 23.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Development of photocontrolled BRD4 PROTACs for tongue squamous cell carcinoma (TSCC).

  • Authors : Li Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.; Ma S

Subjects: Drug Development*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/*drug therapy

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113608. Date of Electronic Publication: 2021 Jun 05.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.

  • Authors : Li Z; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.; Departments of Oncologic Sciences and Chemistry, University of South Florida, Tampa, Florida 33612-9497, United States.

Subjects: Drug Discovery*; Piperidines/Piperidines/Piperidines/*pharmacology ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2021 Aug 12; Vol. 64 (15), pp. 11195-11218. Date of Electronic Publication: 2021 Jul 16.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

YAP-dependent proliferation by a small molecule targeting annexin A2.

  • Authors : Shalhout SZ; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

Subjects: Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*metabolism ; Annexin A2/Annexin A2/Annexin A2/*antagonists & inhibitors ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*pharmacology

  • Source: Nature chemical biology [Nat Chem Biol] 2021 Jul; Vol. 17 (7), pp. 767-775. Date of Electronic Publication: 2021 Mar 15.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Discovery of an Unexpected Similarity in Ligand Binding between BRD4 and PPARγ.

  • Authors : Humbeck L; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Straße 6, 44227 Dortmund, Germany.; Pretzel J

Subjects: Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*metabolism ; PPAR gamma/PPAR gamma/PPAR gamma/*metabolism ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*metabolism

  • Source: ACS chemical biology [ACS Chem Biol] 2021 Jul 16; Vol. 16 (7), pp. 1255-1265. Date of Electronic Publication: 2021 Jun 28.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.

  • Authors : Wang Z; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.; Zhang M

Subjects: Drug Design*; Piperidines/Piperidines/Piperidines/*chemistry ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*chemistry

  • Source: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5886-5904. Date of Electronic Publication: 2021 Apr 26.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

BET bromodomain inhibitors regulate keratinocyte plasticity.

  • Authors : Schutzius G; Novartis Institutes for BioMedical Research, Basel, Switzerland.; Kolter C

Subjects: Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*genetics ; Epidermis/Epidermis/Epidermis/*drug effects ; Re-Epithelialization/Re-Epithelialization/Re-Epithelialization/*drug effects

  • Source: Nature chemical biology [Nat Chem Biol] 2021 Mar; Vol. 17 (3), pp. 280-290. Date of Electronic Publication: 2021 Jan 18.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Selective Fragments for the CREBBP Bromodomain Identified from an Encoded Self-assembly Chemical Library.

  • Authors : Catalano M; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.; Moroglu M

Subjects: Benzodiazepinones/Benzodiazepinones/Benzodiazepinones/*pharmacology ; CREB-Binding Protein/CREB-Binding Protein/CREB-Binding Protein/*antagonists & inhibitors ; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*antagonists & inhibitors

  • Source: ChemMedChem [ChemMedChem] 2020 Sep 16; Vol. 15 (18), pp. 1752-1756. Date of Electronic Publication: 2020 Aug 19.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187

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Academic Journal

Development of small-molecule BRD4 degraders based on pyrrolopyridone derivative.

  • Authors : Zhang J; Center of Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China.; Chen P

Subjects: Drug Development*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*antagonists & inhibitors

  • Source: Bioorganic chemistry [Bioorg Chem] 2020 Jun; Vol. 99, pp. 103817. Date of Electronic Publication: 2020 Apr 09.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites.

  • Authors : Olp MD; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Sprague DJ

Subjects: Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*metabolism ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*metabolism ; Transcription Factors/Transcription Factors/Transcription Factors/*metabolism

  • Source: ACS chemical biology [ACS Chem Biol] 2020 Apr 17; Vol. 15 (4), pp. 1036-1049. Date of Electronic Publication: 2020 Mar 23.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  191 results for ""Small Molecule Libraries""