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Academic Journal

Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na + /K + -ATPase independent proteolysis.

  • Authors : Yang CW; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 35053, Taiwan, ROC.; Hsu HY

Subjects: Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Cardenolides/Cardenolides/Cardenolides/*pharmacology ; Coronavirus OC43, Human/Coronavirus OC43, Human/Coronavirus OC43, Human/*drug effects

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114122. Date of Electronic Publication: 2020 Jun 25.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Conformational states of the pig kidney Na + /K + -ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study.

  • Authors : Azalim P; Laboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.; do Monte FM

Subjects: Protein Conformation* ; Structure-Activity Relationship*; Bufanolides/Bufanolides/Bufanolides/*chemistry

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2020 Jan; Vol. 171, pp. 113679. Date of Electronic Publication: 2019 Oct 24.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Toxicity of Milkweed Leaves and Latex: Chromatographic Quantification Versus Biological Activity of Cardenolides in 16 Asclepias Species.

  • Authors : Züst T; Institute of Plant Sciences, University of Bern, 3013, Bern, Switzerland. .; Petschenka G

Subjects: Herbivory*; Asclepias/Asclepias/Asclepias/*physiology ; Butterflies/Butterflies/Butterflies/*physiology

  • Source: Journal of chemical ecology [J Chem Ecol] 2019 Jan; Vol. 45 (1), pp. 50-60. Date of Electronic Publication: 2018 Dec 07.Publisher: Springer Country of Publication: United States NLM ID: 7505563 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Identification of anti-viral activity of the cardenolides, Na + /K + -ATPase inhibitors, against porcine transmissible gastroenteritis virus.

  • Authors : Yang CW; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 35053, Taiwan, ROC.; Chang HY

Subjects: Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Cardenolides/Cardenolides/Cardenolides/*pharmacology ; Sodium-Potassium-Exchanging ATPase/Sodium-Potassium-Exchanging ATPase/Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2017 Oct 01; Vol. 332, pp. 129-137. Date of Electronic Publication: 2017 Apr 23.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Structures, chemotaxonomic significance, cytotoxic and Na(+),K(+)-ATPase inhibitory activities of new cardenolides from Asclepias curassavica.

  • Authors : Zhang RR; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China. .; Tian HY

Subjects: Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/*pharmacology ; Asclepias/Asclepias/Asclepias/*chemistry ; Cardenolides/Cardenolides/Cardenolides/*pharmacology

  • Source: Organic & biomolecular chemistry [Org Biomol Chem] 2014 Nov 28; Vol. 12 (44), pp. 8919-29.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Amino acid substitutions of Na,K-ATPase conferring decreased sensitivity to cardenolides in insects compared to mammals.

  • Authors : Dalla S; Molecular Evolutionary Biology, Biocenter Grindel, Universität Hamburg, Martin-Luther-King Pl. 3, 20146 Hamburg, Germany.; Swarts HG

Subjects: Amino Acid Substitution/Amino Acid Substitution/Amino Acid Substitution/*genetics ; Cardenolides/Cardenolides/Cardenolides/*pharmacology ; Drosophila Proteins/Drosophila Proteins/Drosophila Proteins/*metabolism

  • Source: Insect biochemistry and molecular biology [Insect Biochem Mol Biol] 2013 Dec; Vol. 43 (12), pp. 1109-15. Date of Electronic Publication: 2013 Oct 08.Publisher: Elsevier Science Country of Publication: England NLM ID: 9207282 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Stepwise evolution of resistance to toxic cardenolides via genetic substitutions in the Na+/K+ -ATPase of milkweed butterflies (lepidoptera: Danaini).

  • Authors : Petschenka G; Biozentrum Grindel, Martin-Luther-King-Platz 3, 20146, Hamburg, Germany. .; Fandrich S

Subjects: Evolution, Molecular*; Butterflies/Butterflies/Butterflies/*genetics ; Cardenolides/Cardenolides/Cardenolides/*toxicity

  • Source: Evolution; international journal of organic evolution [Evolution] 2013 Sep; Vol. 67 (9), pp. 2753-61. Date of Electronic Publication: 2013 May 30.Publisher: Oxford University Press Country of Publication: United States NLM ID: 0373224 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in the Na,K-ATPase.

  • Authors : Dobler S; Department of Biology, Hamburg University, 20146 Hamburg, Germany. ; Dalla S

Subjects: Evolution, Molecular* ; Models, Molecular*; Adaptation, Biological/Adaptation, Biological/Adaptation, Biological/*genetics

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Aug 07; Vol. 109 (32), pp. 13040-5. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Editorial & Opinion

Cardenolides and bufadienolides as hormones: what is missing?

Subjects: Bufanolides/Bufanolides/Bufanolides/*pharmacology ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Kidney/Kidney/Kidney/*drug effects

  • Source: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2012 Apr 15; Vol. 302 (8), pp. F957-8. Date of Electronic Publication: 2012 Feb 01.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.

  • Authors : Piacente S; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Salerno, Italy. ; Masullo M

Subjects: Apocynaceae/Apocynaceae/Apocynaceae/*chemistry ; Cardenolides/Cardenolides/Cardenolides/*isolation & purification ; Cardenolides/Cardenolides/Cardenolides/*pharmacology

  • Source: Journal of natural products [J Nat Prod] 2009 Jun; Vol. 72 (6), pp. 1087-91.Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print Cited Medium: Internet

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  • 1-10 of  17 results for ""Cardenolides""