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Academic Journal

Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice.

  • Authors : Chen L; 1 Department of Pharmacy, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.; Cui S

Subjects: Anxiety/Anxiety/Anxiety/*metabolism ; Behavior, Animal/Behavior, Animal/Behavior, Animal/*physiology ; Central Amygdaloid Nucleus/Central Amygdaloid Nucleus/Central Amygdaloid Nucleus/*metabolism

  • Source: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2019 May; Vol. 33 (5), pp. 568-576. Date of Electronic Publication: 2019 Mar 05.Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Therapeutic Implications for PDE2 and cGMP/cAMP Mediated Crosstalk in Cardiovascular Diseases.

  • Authors : Sadek MS; Department of Pharmacology and Toxicology, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.; Cachorro E

Subjects: Signal Transduction*; Cardiovascular Diseases/Cardiovascular Diseases/Cardiovascular Diseases/*etiology ; Cardiovascular Diseases/Cardiovascular Diseases/Cardiovascular Diseases/*metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2020 Oct 10; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

β 3 -Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes.

  • Authors : Schobesberger S; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, London, United Kingdom.; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, German Center for Cardiovascular Research (DZHK) partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.

Subjects: Signal Transduction*; Cyclic GMP/Cyclic GMP/Cyclic GMP/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/*metabolism

  • Source: ELife [Elife] 2020 Mar 31; Vol. 9. Date of Electronic Publication: 2020 Mar 31.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet

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Academic Journal

Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes.

  • Authors : Banerjee J; NuSirt Biopharma Inc., 11020 Solway School Rd, Knoxville, TN 37931, USA. .; Bruckbauer A

Subjects: Adipocytes/Adipocytes/Adipocytes/*drug effects ; Adipocytes/Adipocytes/Adipocytes/*physiology ; Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/*metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2019 Jun 19; Vol. 20 (12). Date of Electronic Publication: 2019 Jun 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure.

  • Authors : Baliga RS; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.; Preedy MEJ

Subjects: Cyclic GMP/Cyclic GMP/Cyclic GMP/*physiology ; Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/*physiology ; Guanylate Cyclase/Guanylate Cyclase/Guanylate Cyclase/*physiology

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 31; Vol. 115 (31), pp. E7428-E7437. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways.

  • Authors : Vettel C; Institute of Pharmacology, University Medical Center Göttingen, Germany;

Subjects: Cyclic AMP/Cyclic AMP/Cyclic AMP/*metabolism ; Cyclic GMP/Cyclic GMP/Cyclic GMP/*physiology ; Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/*physiology

  • Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2014 Apr 15; Vol. 306 (8), pp. H1246-52. Date of Electronic Publication: 2014 FebPublisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis.

  • Authors : Wang D; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.; O'Halloran D

Subjects: Signal Transduction* ; Thermosensing*; Caenorhabditis elegans Proteins/Caenorhabditis elegans Proteins/Caenorhabditis elegans Proteins/*metabolism

  • Source: The Journal of general physiology [J Gen Physiol] 2013 Oct; Vol. 142 (4), pp. 437-49.Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985110R Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway.

  • Authors : Xu Y; Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV 26505, USA. ; Pan J

Subjects: Corticosterone/Corticosterone/Corticosterone/*toxicity ; Cyclic GMP-Dependent Protein Kinases/Cyclic GMP-Dependent Protein Kinases/Cyclic GMP-Dependent Protein Kinases/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/*antagonists & inhibitors

  • Source: The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2013 May; Vol. 16 (4), pp. 835-47. Date of Electronic Publication: 2012 Jul 31.Publisher: Oxford University Press Country of Publication: England NLM ID: 9815893 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF- κ B/p65 Signaling in Chronic Radiculitis Rats.

  • Authors : Wang J; Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong 250021, China.; Wu M

Subjects: Hyperalgesia/Hyperalgesia/Hyperalgesia/*therapy ; Oxygen/Oxygen/Oxygen/*therapeutic use ; Ozone/Ozone/Ozone/*therapeutic use

  • Source: Pain research & management [Pain Res Manag] 2018 Dec 13; Vol. 2018, pp. 5192814. Date of Electronic Publication: 2018 Dec 13 (Print Publication: 2018).Publisher: Hindawi Publishing Corporation Country of Publication: United States NLM ID: 9612504 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Molecular Analysis of Sensory Axon Branching Unraveled a cGMP-Dependent Signaling Cascade.

Subjects: Signal Transduction*; Axons/Axons/Axons/*metabolism ; Cyclic GMP/Cyclic GMP/Cyclic GMP/*metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2018 Apr 24; Vol. 19 (5). Date of Electronic Publication: 2018 Apr 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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  • 1-10 of  24 results for ""Cyclic Nucleotide Phosphodiesterases, Type 2""