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Academic Journal

TREM2 signaling in Parkinson's disease: Regulation of microglial function and α-synuclein pathology.

  • Authors : Yin S; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.; Chi X

Subjects: Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/metabolism ; Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/genetics ; Microglia*/Microglia*/Microglia*/metabolism

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Dec 25; Vol. 143 (Pt 2), pp. 113446. Date of Electronic Publication: 2024 Oct 29.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Role of TREM2 in immune and neurological diseases: Structure, function, and implications.

  • Authors : Yin P; International Genome Center, Jiangsu University, Zhenjiang 212013, China.; Su Z

Subjects: Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/metabolism ; Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/immunology ; Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/metabolism

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Dec 25; Vol. 143 (Pt 1), pp. 113286. Date of Electronic Publication: 2024 Oct 07.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.

  • Authors : Carling GK; Helen and Robert Appel Alzheimer's Disease Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA; Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA.

Subjects: Microglia*/Microglia*/Microglia*/metabolism ; Microglia*/Microglia*/Microglia*/pathology ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/genetics

  • Source: Neuron [Neuron] 2024 Dec 04; Vol. 112 (23), pp. 3877-3896.e8. Date of Electronic Publication: 2024 Sep 30.Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A Strategy Involving Microporous Microneedles Integrated with CAR-TREM2-Macrophages for Scar Management by Regulating Fibrotic Microenvironment.

  • Authors : Liu M; Department of Cell Biology, Army Medical University, Chongqing, 400038, China.; Zhou X

Subjects: Cicatrix*/Cicatrix*/Cicatrix*/metabolism ; Macrophages*/Macrophages*/Macrophages*/metabolism ; Fibroblasts*/Fibroblasts*/Fibroblasts*/metabolism

  • Source: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Dec; Vol. 36 (49), pp. e2406153. Date of Electronic Publication: 2024 Sep 23.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095

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Academic Journal

Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway.

  • Authors : Li L; Department of Neurology, the Third Affiliated Hospital of Qiqihar Medical College, Qiqihar, China.; Chen Q

Subjects: Signal Transduction* ; Phosphatidylinositol 3-Kinases*/Phosphatidylinositol 3-Kinases*/Phosphatidylinositol 3-Kinases*/metabolism ; Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/metabolism

  • Source: Biotechnology & genetic engineering reviews [Biotechnol Genet Eng Rev] 2024 Dec; Vol. 40 (4), pp. 4040-4061. Date of Electronic Publication: 2023 Apr 26.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8510274 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Npc1 deficiency impairs microglia function via TREM2-mTOR signaling in Niemann-Pick disease type C.

  • Authors : Qiao L; Stem Cells and Biotherapy Engineering Research Center of Henan, National Joint Engineering Laboratory of Stem Cells and Biotherapy, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, China.; Han X

Subjects: Niemann-Pick C1 Protein* ; Niemann-Pick Disease, Type C*/Niemann-Pick Disease, Type C*/Niemann-Pick Disease, Type C*/metabolism ; Niemann-Pick Disease, Type C*/Niemann-Pick Disease, Type C*/Niemann-Pick Disease, Type C*/pathology

  • Source: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Dec; Vol. 1870 (8), pp. 167478. Date of Electronic Publication: 2024 Aug 22.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Both TREM2-dependent macrophages and Kupffer cells play a protective role in APAP-induced acute liver injury.

  • Authors : Chao S; Department of Toxicology and Nutrition, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, China; Qinghai Center for Disease Control and Prevention, No. 55, Bayi Middle Road, Chengdong District, Xining City, Qinghai Province 810000, China.

Subjects: Kupffer Cells*/Kupffer Cells*/Kupffer Cells*/metabolism ; Kupffer Cells*/Kupffer Cells*/Kupffer Cells*/immunology ; Acetaminophen*

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Nov 15; Vol. 141, pp. 112926. Date of Electronic Publication: 2024 Aug 18.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Transcriptome and proteome profiling reveals TREM2-dependent and -independent glial response and metabolic perturbation in an Alzheimer's mouse model.

  • Authors : Lin D; Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Kaye S

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/genetics ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/pathology

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Nov; Vol. 300 (11), pp. 107874. Date of Electronic Publication: 2024 Oct 11.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Loss of TREM2 diminishes CAA despite an overall increase of amyloid load in Tg-SwDI mice.

  • Authors : Zhong R; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.; Xu Y

Subjects: Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/genetics ; Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/metabolism ; Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/genetics

  • Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Nov; Vol. 20 (11), pp. 7595-7612. Date of Electronic Publication: 2024 Sep 23.Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

LILRB4 represents a promising target for immunotherapy by dual targeting tumor cells and myeloid-derived suppressive cells in multiple myeloma.

  • Authors : Gong L; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; Tianjin Institutes of Health Science, Tianjin.

Subjects: Multiple Myeloma*/Multiple Myeloma*/Multiple Myeloma*/therapy ; Multiple Myeloma*/Multiple Myeloma*/Multiple Myeloma*/immunology ; Multiple Myeloma*/Multiple Myeloma*/Multiple Myeloma*/genetics

  • Source: Haematologica [Haematologica] 2024 Nov 01; Vol. 109 (11), pp. 3650-3669. Date of Electronic Publication: 2024 Nov 01.Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  2,598 results for ""MEMBRANE glycoproteins""