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Academic Journal

Physiologically Based Pharmacokinetic (PBPK) Modeling of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIs).

  • Authors : Duan P; Office of Commissioner, USFDA, Silver Spring, MD, USA.; Office of New Drug Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, USFDA, Silver Spring, MD, USA.

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics ; Models, Biological*

  • Source: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2017 Aug; Vol. 42 (4), pp. 689-705.Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print Cited Medium: Internet ISSN: 2107-0180

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Academic Journal

In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.

  • Authors : Ufuk A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, United Kingdom (A.U., J.B.H., A.G.); and Pharmacokinetics, Dynamics, and Metabolism (R.E.K., H.G., Y.-A.B., A.D.R., L.M.T., M.V.S.V.) and Research Formulations, Pharmaceutical Sciences (S.M., D.G.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut.

Subjects: Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism ; Quinolines/Quinolines/Quinolines/*pharmacology

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2018 Jun; Vol. 365 (3), pp. 688-699. Date of Electronic Publication: 2018 Apr 11.Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide.

Subjects: Antifungal Agents/Antifungal Agents/Antifungal Agents/*metabolism ; Cyclosporine/Cyclosporine/Cyclosporine/*metabolism ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/*metabolism

  • Source: Biopharmaceutics & drug disposition [Biopharm Drug Dispos] 2016 Nov; Vol. 37 (8), pp. 479-490. Date of Electronic Publication: 2016 Oct 14.Publisher: Wiley Country of Publication: England NLM ID: 7911226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-081X

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Academic Journal

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans.

  • Authors : Hirano M; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.; Maeda K

Subjects: Estrone/Estrone/Estrone/*analogs & derivatives ; Liver/Liver/Liver/*metabolism ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2004 Oct; Vol. 311 (1), pp. 139-46. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism.

  • Authors : Cho CK; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Mo JY

Subjects: Hydroxymethylglutaryl-CoA Reductase Inhibitors* ; Quinolines*/Quinolines*/Quinolines*/pharmacokinetics ; Organic Anion Transporters*/Organic Anion Transporters*/Organic Anion Transporters*/genetics

  • Source: Archives of pharmacal research [Arch Pharm Res] 2024 Feb; Vol. 47 (2), pp. 95-110. Date of Electronic Publication: 2023 Dec 30.Publisher: Pharmaceutical Society of Korea Country of Publication: Korea (South) NLM ID: 8000036 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Pharmacokinetic herb-disease-drug interactions: Effect of ginkgo biloba extract on the pharmacokinetics of pitavastatin, a substrate of Oatp1b2, in rats with non-alcoholic fatty liver disease.

  • Authors : Li Z; Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300250, China. Electronic address: .; Tian S

Subjects: Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacokinetics ; Non-alcoholic Fatty Liver Disease/Non-alcoholic Fatty Liver Disease/Non-alcoholic Fatty Liver Disease/*physiopathology ; Plant Extracts/Plant Extracts/Plant Extracts/*pharmacology

  • Source: Journal of ethnopharmacology [J Ethnopharmacol] 2021 Nov 15; Vol. 280, pp. 114469. Date of Electronic Publication: 2021 Jul 27.Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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A Clinical Drug-Drug Interaction Study Assessing a Novel Drug Transporter Phenotyping Cocktail With Adefovir, Sitagliptin, Metformin, Pitavastatin, and Digoxin.

  • Authors : Trueck C; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, Cologne, Germany.; Hsin CH

Subjects: Adenine/Adenine/Adenine/*analogs & derivatives ; Digoxin/Digoxin/Digoxin/*pharmacokinetics ; Metformin/Metformin/Metformin/*pharmacokinetics

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2019 Dec; Vol. 106 (6), pp. 1398-1407. Date of Electronic Publication: 2019 Aug 12.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Academic Journal

Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes.

  • Authors : Takahashi T; Mitsubishi Tanabe Pharma Corporation, Toda, Saitama, 335-8505, Japan.; Uno Y

Subjects: Organic Anion Transporters/Organic Anion Transporters/Organic Anion Transporters/*metabolism ; Quinolines/Quinolines/Quinolines/*metabolism ; Recombinant Proteins/Recombinant Proteins/Recombinant Proteins/*metabolism

  • Source: Biopharmaceutics & drug disposition [Biopharm Drug Dispos] 2019 Feb; Vol. 40 (2), pp. 62-69. Date of Electronic Publication: 2019 Feb 10.Publisher: Wiley Country of Publication: England NLM ID: 7911226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-081X

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Academic Journal

Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics.

  • Authors : Hirvensalo P; Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Tornio A

Subjects: Acetates/Acetates/Acetates/*pharmacokinetics ; Cytochrome P-450 CYP1A2 Inducers/Cytochrome P-450 CYP1A2 Inducers/Cytochrome P-450 CYP1A2 Inducers/*pharmacokinetics ; Glucuronosyltransferase/Glucuronosyltransferase/Glucuronosyltransferase/*genetics

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2018 Jul; Vol. 104 (1), pp. 158-168. Date of Electronic Publication: 2017 Nov 06.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling.

  • Authors : Mitra P; Drug Metabolism and Pharmacokinetics Department, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut .; Weinheimer S

Subjects: Biological Transport/Biological Transport/Biological Transport/*physiology ; Hepatocytes/Hepatocytes/Hepatocytes/*metabolism ; Liver/Liver/Liver/*metabolism

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2018 Jul; Vol. 46 (7), pp. 953-963. Date of Electronic Publication: 2018 Apr 17.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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  • 1-10 of  27 results for ""Liver-Specific Organic Anion Transporter 1""