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Academic Journal

Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate.

  • Authors : Bernardo LB; Instituto Militar de Engenharia (IME), Praça General Tibúrcio 80, Rio de Janeiro, RJ, 22290-270, Brazil. .; Instituto de Defesa Química, Biológica, Radiológica e Nuclear (IDQBRN), Centro Tecnológico do Exército (CTEx), Avenida das Américas 28705, Área 4, Rio de Janeiro, RJ, 23020-470, Brazil. .

Subjects: Oximes*/Oximes*/Oximes*/pharmacology ; Acetylcholinesterase*/Acetylcholinesterase*/Acetylcholinesterase*/metabolism ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology

  • Source: Archives of toxicology [Arch Toxicol] 2024 Oct; Vol. 98 (10), pp. 3397-3407. Date of Electronic Publication: 2024 Jul 14.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Pharmacokinetics of three novel pyridinium aldoxime acetylcholinesterase reactivators in female rats.

  • Authors : Backer BS; College of Veterinary Medicine, Department of Comparative Biomedical Sciences, Center for Environmental Health Sciences, Mississippi State University, Mississippi State, MS 39762, United States of America.; Meek EC

Subjects: Acetylcholinesterase*/Acetylcholinesterase*/Acetylcholinesterase*/chemistry ; Acetylcholinesterase*/Acetylcholinesterase*/Acetylcholinesterase*/metabolism ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Jul 01; Vol. 446, pp. 116046. Date of Electronic Publication: 2022 May 10.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.

  • Authors : Kranawetvogl T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.; Walther-Straub-Institut, Ludwig-Maximilians-Universität, Munich, Germany.

Subjects: Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/*methods ; Obidoxime Chloride/Obidoxime Chloride/Obidoxime Chloride/*analysis ; Oximes/Oximes/Oximes/*analysis

  • Source: Drug testing and analysis [Drug Test Anal] 2020 Jul; Vol. 12 (7), pp. 938-947. Date of Electronic Publication: 2020 Apr 23.Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication.

  • Authors : Arshad M; a Department of Biosciences , COMSATS Institute of Information Technology , Islamabad , Pakistan.; Fatmi MQ

Subjects: Molecular Docking Simulation*; Antidotes/Antidotes/Antidotes/*pharmacology ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity

  • Source: Toxicology mechanisms and methods [Toxicol Mech Methods] 2018 Jan; Vol. 28 (1), pp. 62-68. Date of Electronic Publication: 2017 Aug 04.Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats.

  • Authors : Kassa J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic. .; Hatlapatková J

Subjects: Chemical Warfare Agents*/Chemical Warfare Agents*/Chemical Warfare Agents*/toxicity ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology ; Organophosphates*

  • Source: Acta medica (Hradec Kralove) [Acta Medica (Hradec Kralove)] 2021; Vol. 64 (3), pp. 145-152.Publisher: Facultas Medica Hradec Kralove, Universitas Carolina Country of Publication: Czech Republic NLM ID: 9705947 Publication Model: Print Cited

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Academic Journal

Novel pyridinium oximes enhance 24-h survivability against a lethal dose of nerve agent surrogate in adult female rats.

  • Authors : Garcia JM; Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Mississippi State, MS, 39762, USA. Electronic address: .; Meek EC

Subjects: Antidotes/Antidotes/Antidotes/*pharmacology ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity ; Nerve Agents/Nerve Agents/Nerve Agents/*toxicity

  • Source: Toxicology [Toxicology] 2020 Dec 15; Vol. 446, pp. 152626. Date of Electronic Publication: 2020 Nov 04.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185

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Academic Journal

An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.

  • Authors : Calas AG; Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge Cédex, France; COGNition and ACtion Group, UMR 8257, CNRS-MD-UPV, Centre universitaire des Saints-Pères, Paris, France. Electronic address: .

Subjects: Blood Chemical Analysis/Blood Chemical Analysis/Blood Chemical Analysis/*methods ; Blood-Brain Barrier/Blood-Brain Barrier/Blood-Brain Barrier/*drug effects ; Chemical Warfare Agents/Chemical Warfare Agents/Chemical Warfare Agents/*toxicity

  • Source: Chemico-biological interactions [Chem Biol Interact] 2017 Apr 01; Vol. 267, pp. 11-16. Date of Electronic Publication: 2016 Mar 10.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786

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Academic Journal

Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators.

  • Authors : Hepnarova V; University of Defence, Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic; University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.

Subjects: Maximum Tolerated Dose*; Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*administration & dosage ; Organophosphorus Compounds/Organophosphorus Compounds/Organophosphorus Compounds/*toxicity

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2019 Nov 15; Vol. 383, pp. 114776. Date of Electronic Publication: 2019 Oct 17.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions.

  • Authors : Xie LN; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.

Subjects: Chemical Warfare Agents/Chemical Warfare Agents/Chemical Warfare Agents/*chemistry ; Chloranil/Chloranil/Chloranil/*chemistry ; Nerve Agents/Nerve Agents/Nerve Agents/*chemistry

  • Source: Free radical biology & medicine [Free Radic Biol Med] 2019 Jan; Vol. 130, pp. 1-7. Date of Electronic Publication: 2018 Oct 21.Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.

  • Authors : Cuya T; a Faculty of Technology , University of the State of Rio de Janeiro , Resende, Rio de Janeiro , Brazil.; Gonçalves ADS

Subjects: Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*metabolism ; Chemical Warfare Agents/Chemical Warfare Agents/Chemical Warfare Agents/*chemistry ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*chemistry

  • Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2018 Oct; Vol. 36 (13), pp. 3444-3452. Date of Electronic Publication: 2017 Oct 27.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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