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Academic Journal

A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.

  • Authors : Kranawetvogl T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.; Walther-Straub-Institut, Ludwig-Maximilians-Universität, Munich, Germany.

Subjects: Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/*methods ; Obidoxime Chloride/Obidoxime Chloride/Obidoxime Chloride/*analysis ; Oximes/Oximes/Oximes/*analysis

  • Source: Drug testing and analysis [Drug Test Anal] 2020 Jul; Vol. 12 (7), pp. 938-947. Date of Electronic Publication: 2020 Apr 23.Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication.

  • Authors : Arshad M; a Department of Biosciences , COMSATS Institute of Information Technology , Islamabad , Pakistan.; Fatmi MQ

Subjects: Molecular Docking Simulation*; Antidotes/Antidotes/Antidotes/*pharmacology ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity

  • Source: Toxicology mechanisms and methods [Toxicol Mech Methods] 2018 Jan; Vol. 28 (1), pp. 62-68. Date of Electronic Publication: 2017 Aug 04.Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Novel pyridinium oximes enhance 24-h survivability against a lethal dose of nerve agent surrogate in adult female rats.

  • Authors : Garcia JM; Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Mississippi State, MS, 39762, USA. Electronic address: .; Meek EC

Subjects: Antidotes/Antidotes/Antidotes/*pharmacology ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity ; Nerve Agents/Nerve Agents/Nerve Agents/*toxicity

  • Source: Toxicology [Toxicology] 2020 Dec 15; Vol. 446, pp. 152626. Date of Electronic Publication: 2020 Nov 04.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185

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Academic Journal

An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.

  • Authors : Calas AG; Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge Cédex, France; COGNition and ACtion Group, UMR 8257, CNRS-MD-UPV, Centre universitaire des Saints-Pères, Paris, France. Electronic address: .

Subjects: Blood Chemical Analysis/Blood Chemical Analysis/Blood Chemical Analysis/*methods ; Blood-Brain Barrier/Blood-Brain Barrier/Blood-Brain Barrier/*drug effects ; Chemical Warfare Agents/Chemical Warfare Agents/Chemical Warfare Agents/*toxicity

  • Source: Chemico-biological interactions [Chem Biol Interact] 2017 Apr 01; Vol. 267, pp. 11-16. Date of Electronic Publication: 2016 Mar 10.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786

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Academic Journal

The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.

  • Authors : Cuya T; a Faculty of Technology , University of the State of Rio de Janeiro , Resende, Rio de Janeiro , Brazil.; Gonçalves ADS

Subjects: Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*metabolism ; Chemical Warfare Agents/Chemical Warfare Agents/Chemical Warfare Agents/*chemistry ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*chemistry

  • Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2018 Oct; Vol. 36 (13), pp. 3444-3452. Date of Electronic Publication: 2017 Oct 27.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice.

  • Authors : dos Santos AA; Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88040900, Florianópolis, Santa Catarina, Brazil. ; dos Santos DB

Subjects: Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*metabolism ; Antidotes/Antidotes/Antidotes/*pharmacology ; Antioxidants/Antioxidants/Antioxidants/*metabolism

  • Source: Neurotoxicology [Neurotoxicology] 2011 Dec; Vol. 32 (6), pp. 888-95. Date of Electronic Publication: 2011 Jun 22.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP.

  • Authors : Kovarik Z; Institute for Medical Research and Occupational Health, Ksaverska c. 2, POB 291, HR-10001 Zagreb, Croatia. ; Ciban N

Subjects: Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*chemistry ; Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*metabolism ; Dichlorvos/Dichlorvos/Dichlorvos/*metabolism

  • Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2006 Apr 14; Vol. 342 (3), pp. 973-8.Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print Cited Medium: Print ISSN: 0006-291X (Print)

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Academic Journal

A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.

  • Authors : Koplovitz I; Drug Assessment Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD.; Stewart JR

Subjects: Antidotes/Antidotes/Antidotes/*pharmacology ; Chemical Warfare Agents/Chemical Warfare Agents/Chemical Warfare Agents/*poisoning ; Organophosphorus Compounds/Organophosphorus Compounds/Organophosphorus Compounds/*antagonists & inhibitors

  • Source: Toxicology letters [Toxicol Lett] 1994 Feb 15; Vol. 70 (3), pp. 269-79.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print Cited Medium: Print ISSN: 0378-4274 (Print)

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Academic Journal

HI-6 and 2-PAM in sheep: pharmacokinetics and effects on muscle tissue following intramuscular injection.

  • Authors : Moore DH; United States Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground, Maryland.; Hayward IJ

Subjects: Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*pharmacokinetics ; Muscles/Muscles/Muscles/*drug effects ; Pralidoxime Compounds/Pralidoxime Compounds/Pralidoxime Compounds/*pharmacology

  • Source: Biopharmaceutics & drug disposition [Biopharm Drug Dispos] 1991 Apr; Vol. 12 (3), pp. 223-32.Publisher: Wiley Country of Publication: England NLM ID: 7911226 Publication Model: Print Cited Medium: Print ISSN: 0142-2782 (Print) Linking

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In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048.

  • Authors : Pohanka M; Faculty of Military Health Sciences, Center of Advanced Studies, University of Defence, Hradec Kralove, Czech Republic.; Jun D

Subjects: Butyrylcholinesterase/Butyrylcholinesterase/Butyrylcholinesterase/*metabolism ; Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*pharmacology ; Obidoxime Chloride/Obidoxime Chloride/Obidoxime Chloride/*pharmacology

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2009 Jun; Vol. 24 (3), pp. 680-3.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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  • 1-10 of  71 results for ""Pralidoxime Compounds""