Search Results

Display Settings
Results per page: 10
Sort By: Relevance
Filter
  • 1-10 of  2,062 results for ""Ubiquitin-Protein Ligases""

Your Filters

Subject : proteolysis
Reset filters
Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request
Academic Journal

Repurposing Tolfenamic Acid to Anchor the Uncharacterized Pocket of the PUB Domain for Proteolysis of the Atypical E3 Ligase HOIP.

  • Authors : Zhong F; The First Affiliated Hospital & School of Life Sciences, Ministry of Education Key Laboratory for Membrane-Less Organelles & Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Biomedical Sciences and Health Laboratory of Anhui Province, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Zhou Y

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/chemistry ; ortho-Aminobenzoates*/ortho-Aminobenzoates*/ortho-Aminobenzoates*/chemistry

  • Source: ACS chemical biology [ACS Chem Biol] 2024 Dec 20; Vol. 19 (12), pp. 2469-2476. Date of Electronic Publication: 2024 Nov 08.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera.

  • Authors : Bond AG; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K.; Muñoz I Ordoño M

Subjects: Proteolysis* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/chemistry

  • Source: Journal of the American Chemical Society [J Am Chem Soc] 2024 Dec 11; Vol. 146 (49), pp. 33675-33711. Date of Electronic Publication: 2024 Nov 28.Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA).

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Proteolysis*/Proteolysis*/Proteolysis*/drug effects

  • Source: ELife [Elife] 2024 Dec 06; Vol. 13. Date of Electronic Publication: 2024 Dec 06.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network.

  • Authors : Huber AD; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 1000, Memphis, TN 38105-3678, USA.; Lin W

Subjects: Proteolysis* ; Protein Binding* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

  • Source: Structure (London, England : 1993) [Structure] 2024 Dec 05; Vol. 32 (12), pp. 2352-2363.e8. Date of Electronic Publication: 2024 Oct 09.Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

Record details

Read More Add to Saved list
×
Academic Journal

Proteolysis Targeting Chimeras (PROTACs) in Breast Cancer Therapy.

  • Authors : Jin Y; Department of Chemistry, Pusan National University, Busan, 46241, Korea.; Lee Y

Subjects: Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/drug therapy ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/metabolism ; Proteolysis*/Proteolysis*/Proteolysis*/drug effects

  • Source: ChemMedChem [ChemMedChem] 2024 Dec 02; Vol. 19 (23), pp. e202400267. Date of Electronic Publication: 2024 Oct 15.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187

Record details

Read More Add to Saved list
×
Academic Journal

Tripartite motif 25 inhibits protein aggregate degradation during PRRSV infection by suppressing p62-mediated autophagy.

  • Authors : Ren J; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.

Subjects: Porcine respiratory and reproductive syndrome virus*/Porcine respiratory and reproductive syndrome virus*/Porcine respiratory and reproductive syndrome virus*/physiology ; Porcine respiratory and reproductive syndrome virus*/Porcine respiratory and reproductive syndrome virus*/Porcine respiratory and reproductive syndrome virus*/metabolism ; Autophagy*

  • Source: Journal of virology [J Virol] 2024 Nov 19; Vol. 98 (11), pp. e0143724. Date of Electronic Publication: 2024 Oct 31.Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

CRBN-PROTACs in Cancer Therapy: From Mechanistic Insights to Clinical Applications.

  • Authors : Thapa R; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.; Bhat AA

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Neoplasms*/Neoplasms*/Neoplasms*/metabolism ; Neoplasms*/Neoplasms*/Neoplasms*/pathology

  • Source: Chemical biology & drug design [Chem Biol Drug Des] 2024 Nov; Vol. 104 (5), pp. e70009.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285

Record details

Read More Add to Saved list
×
Academic Journal

C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks.

  • Authors : Quiñones JL; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Basic Science Tower 8-140, Stony Brook, New York 11794, USA.; Tang M

Subjects: DNA Polymerase beta*/DNA Polymerase beta*/DNA Polymerase beta*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics

  • Source: DNA repair [DNA Repair (Amst)] 2024 Nov; Vol. 143, pp. 103756. Date of Electronic Publication: 2024 Aug 28.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139138 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

Record details

Read More Add to Saved list
×
Academic Journal

ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effect.

  • Authors : Paik H; Center for Supercomputing Application, Korea Institute of Science and Technology Information (KISTI), 245 Daehak-ro, Daejeon 34141, South Korea.; Center for Biomedical Computing, Korea Institute of Science and Technology Information (KISTI), 245 Daehak-ro, Daejeon 34141, South Korea.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Proteolysis*

  • Source: Database : the journal of biological databases and curation [Database (Oxford)] 2024 Oct 12; Vol. 2024.Publisher: Oxford Journals Country of Publication: England NLM ID: 101517697 Publication Model: Print Cited Medium: Internet ISSN: 1758-0463

Record details

Read More Add to Saved list
×
Academic Journal

Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.

  • Authors : Scott DC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.; Dharuman S

Subjects: Proteolysis* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics

  • Source: Nature communications [Nat Commun] 2024 Oct 12; Vol. 15 (1), pp. 8829. Date of Electronic Publication: 2024 Oct 12.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

Record details

Read More Add to Saved list
×
  • 1-10 of  2,062 results for ""Ubiquitin-Protein Ligases""