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Academic Journal

MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins.

  • Authors : Seo T; Departments of Dermatology and Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, United States of America.; Lowery AM

Subjects: Cadherins*/Cadherins*/Cadherins*/metabolism ; Proteolysis* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

  • Source: PloS one [PLoS One] 2024 May 09; Vol. 19 (5), pp. e0290485. Date of Electronic Publication: 2024 May 09 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Antibody targeting of E3 ubiquitin ligases for receptor degradation.

  • Authors : Marei H; Discovery Oncology, Genentech, South San Francisco, CA, USA.; Tsai WK

Subjects: Antibodies*/Antibodies*/Antibodies*/immunology ; Antibodies*/Antibodies*/Antibodies*/metabolism ; Antibody Specificity*

  • Source: Nature [Nature] 2022 Oct; Vol. 610 (7930), pp. 182-189. Date of Electronic Publication: 2022 Sep 21.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases.

  • Authors : Aublette MC; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom.; Harrison TA

Subjects: Proteolysis* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Ligands

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 May 15; Vol. 64, pp. 128636. Date of Electronic Publication: 2022 Feb 26.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function.

  • Authors : Imamura M; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-Cho, Kodaira, Tokyo, 187-8502, Japan. .; Matsumoto H

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Mutation, Missense*/Mutation, Missense*/Mutation, Missense*/genetics

  • Source: In vitro cellular & developmental biology. Animal [In Vitro Cell Dev Biol Anim] 2024 Aug; Vol. 60 (7), pp. 771-780. Date of Electronic Publication: 2024 Apr 01.Publisher: Springer Country of Publication: Germany NLM ID: 9418515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-706X

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Academic Journal

Application of AlphaFold models in evaluating ligandable cysteines across E3 ligases.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/chemistry ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Cysteine*/Cysteine*/Cysteine*/chemistry

  • Source: Proteins [Proteins] 2024 Jul; Vol. 92 (7), pp. 819-829. Date of Electronic Publication: 2024 Feb 09.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8700181 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

CRL2 KLHDC3 and CRL1 Fbxw7 cooperatively mediate c-Myc degradation.

  • Authors : Motomura S; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.; Yumimoto K

Subjects: F-Box-WD Repeat-Containing Protein 7*/F-Box-WD Repeat-Containing Protein 7*/F-Box-WD Repeat-Containing Protein 7*/metabolism ; F-Box-WD Repeat-Containing Protein 7*/F-Box-WD Repeat-Containing Protein 7*/F-Box-WD Repeat-Containing Protein 7*/genetics ; Proto-Oncogene Proteins c-myc*/Proto-Oncogene Proteins c-myc*/Proto-Oncogene Proteins c-myc*/metabolism

  • Source: Oncogene [Oncogene] 2024 Jun; Vol. 43 (25), pp. 1917-1929. Date of Electronic Publication: 2024 May 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

HECT-Type E3 Ubiquitin Ligases in Cancer.

  • Authors : Bernassola F; Department of Experimental Medicine, TOR, University of Rome 'Tor Vergata', Rome 00133, Italy. Electronic address: .; Chillemi G

Subjects: Carcinogenesis*/Carcinogenesis*/Carcinogenesis*/genetics ; Carcinogenesis*/Carcinogenesis*/Carcinogenesis*/metabolism ; Neoplasms*/Neoplasms*/Neoplasms*/enzymology

  • Source: Trends in biochemical sciences [Trends Biochem Sci] 2019 Dec; Vol. 44 (12), pp. 1057-1075. Date of Electronic Publication: 2019 Oct 11.Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 7610674 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The application of ubiquitin ligases in the PROTAC drug design.

  • Authors : Chen Y; Life Science Institute, Zhejiang University, Hangzhou 310058, China.; Jin J

Subjects: Drug Delivery Systems* ; Drug Design* ; Drug Discovery*

  • Source: Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2020 Jul 10; Vol. 52 (7), pp. 776-790.Publisher: China Science Publishing & Media Ltd Country of Publication: China NLM ID: 101206716 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Proteome-scale discovery of protein degradation and stabilization effectors.

  • Authors : Poirson J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.; Cho H

Subjects: Deubiquitinating Enzymes*/Deubiquitinating Enzymes*/Deubiquitinating Enzymes*/analysis ; Deubiquitinating Enzymes*/Deubiquitinating Enzymes*/Deubiquitinating Enzymes*/metabolism ; Protein Stability*

  • Source: Nature [Nature] 2024 Apr; Vol. 628 (8009), pp. 878-886. Date of Electronic Publication: 2024 Mar 20.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis.

  • Authors : Kevei É; School of Biological Sciences, University of Reading, Whiteknights, UK.; Pokrzywa W

Subjects: Homeostasis* ; Proteolysis*; Molecular Chaperones/Molecular Chaperones/Molecular Chaperones/*metabolism

  • Source: FEBS letters [FEBS Lett] 2017 Sep; Vol. 591 (17), pp. 2616-2635. Date of Electronic Publication: 2017 Jul 24.Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  3,221 results for ""UBIQUITIN ligases""