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Academic Journal

Degradomics defines proteolysis information flow from human knee osteoarthritis cartilage to matched synovial fluid and the contributions of secreted proteases ADAMTS5, MMP13 and CMA1 to articular cartilage breakdown.

  • Authors : Bhutada S; Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA; Musculoskeletal Research Center, Cleveland Clinic, Cleveland, OH, USA.

Subjects: Osteoarthritis, Knee*/Osteoarthritis, Knee*/Osteoarthritis, Knee*/metabolism ; Osteoarthritis, Knee*/Osteoarthritis, Knee*/Osteoarthritis, Knee*/enzymology ; Cartilage, Articular*/Cartilage, Articular*/Cartilage, Articular*/metabolism

  • Source: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2025 Jan; Vol. 33 (1), pp. 116-127. Date of Electronic Publication: 2024 Sep 16.Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited

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Academic Journal

Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.

  • Authors : Mead TJ; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA

Subjects: Versicans*/Versicans*/Versicans*/metabolism ; Versicans*/Versicans*/Versicans*/genetics ; ADAMTS5 Protein*/ADAMTS5 Protein*/ADAMTS5 Protein*/metabolism

  • Source: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2024 Aug; Vol. 131, pp. 1-16. Date of Electronic Publication: 2024 May 13.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9432592 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Saxagliptin suppresses degradation of type II collagen and aggrecan in primary human chondrocytes: a therapeutic implication in osteoarthritis.

  • Authors : Hu N; a Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.; Gong X

Subjects: Adamantane/Adamantane/Adamantane/*analogs & derivatives ; Aggrecans/Aggrecans/Aggrecans/*metabolism ; Chondrocytes/Chondrocytes/Chondrocytes/*drug effects

  • Source: Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 3239-3245.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print Cited Medium: Internet ISSN: 2169-141X

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Academic Journal

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.

Subjects: Antibodies, Monoclonal/Antibodies, Monoclonal/Antibodies, Monoclonal/*pharmacology ; Collagenases/Collagenases/Collagenases/*drug effects ; Low Density Lipoprotein Receptor-Related Protein-1/Low Density Lipoprotein Receptor-Related Protein-1/Low Density Lipoprotein Receptor-Related Protein-1/*drug effects

  • Source: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2017 Jun; Vol. 69 (6), pp. 1246-1256. Date of Electronic Publication: 2017 Apr 28.Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5.

  • Authors : Wang Z; Cell and Molecular Biology Laboratory, Department of Orthopaedics, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA. .; Luo J

Subjects: Proteolysis*; ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism ; Procollagen N-Endopeptidase/Procollagen N-Endopeptidase/Procollagen N-Endopeptidase/*metabolism

  • Source: Molecules (Basel, Switzerland) [Molecules] 2014 Jun 23; Vol. 19 (6), pp. 8472-87. Date of Electronic Publication: 2014 Jun 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.

  • Authors : Demircan K; Department of Medical Biology, Turgut Ozal University School of Medicine, 06200 Ankara, Turkey.; Topcu V

Subjects: Proteolysis*; ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism ; Procollagen N-Endopeptidase/Procollagen N-Endopeptidase/Procollagen N-Endopeptidase/*metabolism

  • Source: BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 693746. Date of Electronic Publication: 2014 Jul 03.Publisher: Wiley Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves.

  • Authors : Dupuis LE; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29464, USA.; Osinska H

Subjects: Proteolysis* ; Signal Transduction*; Aortic Valve/Aortic Valve/Aortic Valve/*abnormalities

  • Source: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2013 Jul; Vol. 60, pp. 50-9. Date of Electronic Publication: 2013 Mar 24.Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators.

  • Authors : Krstic D; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Rodriguez M

Subjects: Proteolysis*; ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism ; Cell Adhesion Molecules, Neuronal/Cell Adhesion Molecules, Neuronal/Cell Adhesion Molecules, Neuronal/*metabolism

  • Source: PloS one [PLoS One] 2012; Vol. 7 (10), pp. e47793. Date of Electronic Publication: 2012 Oct 17.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Shaping Synapses by the Neural Extracellular Matrix.

Subjects: SYNAPSES; EXTRACELLULAR matrix; NEUROPLASTICITY

  • Source: Frontiers in Neuroanatomy; 5/15/2018, p1-16, 16p

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Academic Journal

Crystal structure and substrate-induced activation of ADAMTS13.

Subjects: CRYSTAL structure; VON Willebrand factor; DESMOPRESSIN

  • Source: Nature Communications; 8/22/2019, Vol. 10 Issue 1, pN.PAG-N.PAG, 1p

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  • 1-10 of  11 results for ""ADAMTS5 Protein""