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The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network.

• Authors : Jia H; Hongqiao Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Digestive Endoscopy Center, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Subjects: Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*genetics ; Janus Kinase 1/Janus Kinase 1/Janus Kinase 1/*genetics ; LIM Domain Proteins/LIM Domain Proteins/LIM Domain Proteins/*genetics

• Source: Oncogene [Oncogene] 2017 May 11; Vol. 36 (19), pp. 2655-2666. Date of Electronic Publication: 2016 Nov 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Data on Janus Kinases Reported by Researchers at Walter and Eliza Hall Institute of Medical Research (Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1)

• Source: Obesity, Fitness & Wellness Week. November 23, 2019, 723

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Paradigm shift: combination BET and JAK inhibition in myelofibrosis.

• Authors : Mascarenhas J; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Gerds A

Subjects: Janus Kinases/Janus Kinases/Janus Kinases/*antagonists & inhibitors ; Primary Myelofibrosis/Primary Myelofibrosis/Primary Myelofibrosis/*drug therapy ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*therapeutic use

• Source: Leukemia [Leukemia] 2021 Dec; Vol. 35 (12), pp. 3361-3363. Date of Electronic Publication: 2021 Sep 03.Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium:

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West Virginia University Researchers Update Understanding of Janus Kinases (Janus Kinase 1 Is Required for Transcriptional Reprograming of Murine Astrocytes in Response to Endoplasmic Reticulum Stress)

• Source: Health & Medicine Week. November 1, 2019, 8080

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Study Results from University of Nebraska Medical Center Update Understanding of Cancer (Janus Kinase 1 Plays a Critical Role In Mammary Cancer Progression)

• Source: Health & Medicine Week. June 28, 2019, 7979

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Efficacy and Safety of SHR0302, a Highly Selective Janus Kinase 1 Inhibitor, in Patients with Moderate to Severe Atopic Dermatitis: A Phase II Randomized Clinical Trial.

• Authors : Zhao, Yan; Zhang, Litao; Ding, Yangfeng

Subjects: PROTEINS; DRUG efficacy; SAFETY

• Source: American Journal of Clinical Dermatology; Nov2021, Vol. 22 Issue 6, p877-889, 13p

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Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree.

• Authors : Tawana K; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.; Wang J

Subjects: Codon, Nonsense*; Core Binding Factor Alpha 2 Subunit/Core Binding Factor Alpha 2 Subunit/Core Binding Factor Alpha 2 Subunit/*genetics ; Janus Kinase 2/Janus Kinase 2/Janus Kinase 2/*genetics

• Source: European journal of human genetics : EJHG [Eur J Hum Genet] 2017 Aug; Vol. 25 (8), pp. 1020-1024. Date of Electronic Publication: 2017 May 17.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms.

• Authors : Chen Y; Department of Hematology, Peking University First Hospital, Beijing, China.; Zunyi Medical College Affiliated Hospital, Zunyi, Guizhou, China.

Subjects: Janus Kinase 2/Janus Kinase 2/Janus Kinase 2/*genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/Leukemia, Myelogenous, Chronic, BCR-ABL Positive/Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics ; Polycythemia Vera/Polycythemia Vera/Polycythemia Vera/*genetics

• Source: PloS one [PLoS One] 2016 Apr 25; Vol. 11 (4), pp. e0154183. Date of Electronic Publication: 2016 Apr 25 (Print Publication: 2016).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Baricitinib in Patients with Refractory Rheumatoid Arthritis.

• Authors : Genovese, Mark C.; Kremer, Joel; Zamani, Omid

Subjects: JANUS kinases; RHEUMATOID arthritis treatment; TUMOR necrosis factors

• Source: New England Journal of Medicine. 3/31/2016, Vol. 374 Issue 13, p1243-1252. 10p.

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Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active psoriatic arthritis (EQUATOR): results from a randomised, placebo-controlled, phase 2 trial.

• Authors : Mease, Philip; Mozaffarian, Neelufar; Greer, Joy M.

Subjects: ANTIRHEUMATIC agents; COMBINATION drug therapy; COMPARATIVE studies

• Source: Lancet. 12/1/2018, Vol. 392 Issue 10162, p2367-2377. 9p.

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