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PEGylation Strategy for Improving the Pharmacokinetic and Antitumoral Activity of the IL-2 No-alpha Mutein.

• Authors : Díaz-Hernández M; Department of Immune-regulation, Center of Molecular Immunology (Cuba), Havana, Cuba.; Chang-Calderón J

Subjects: Interleukin-2* ; Proteins*; Humans

• Source: Current pharmaceutical design [Curr Pharm Des] 2023; Vol. 29 (44), pp. 3579-3588.Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9602487 Publication Model: Print Cited Medium: Internet

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Interleukin-2 superkines by computational design.

• Authors : Ren J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.; HHMI, Stanford University School of Medicine, Stanford, CA 94305.

Subjects: Interleukin-2*/Interleukin-2*/Interleukin-2*/genetics ; Proteins*/Proteins*/Proteins*/metabolism; Computational Biology/Computational Biology/Computational Biology/methods

• Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Mar 22; Vol. 119 (12), pp. e2117401119. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Transcriptome-wide stability analysis uncovers LARP4-mediated NFκB1 mRNA stabilization during T cell activation.

• Authors : Tian Y; Department of Physics, George Washington University, Washington, DC 20052, USA.; Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Subjects: Interferon-gamma/Interferon-gamma/Interferon-gamma/*genetics ; Interleukin-2/Interleukin-2/Interleukin-2/*genetics ; Proteins/Proteins/Proteins/*genetics

• Source: Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8724-8739.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma.

• Authors : Olsen E; Duke University Medical Center, Durham, NC 27710, USA. ; Duvic M

Subjects: Diphtheria Toxin* ; Interleukin-2*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*therapeutic use

• Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2001 Jan 15; Vol. 19 (2), pp. 376-88.Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print Cited Medium: Print

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Large-Scale Validation of Mixed-Solvent Simulations to Assess Hotspots at Protein-Protein Interaction Interfaces.

• Authors : Ghanakota P; Schrödinger, Inc. , 120 West 45th Street , New York , New York 10036 , United States.; van Vlijmen H

Subjects: Molecular Dynamics Simulation* ; Protein Interaction Maps*; Proteins/Proteins/Proteins/*chemistry

• Source: Journal of chemical information and modeling [J Chem Inf Model] 2018 Apr 23; Vol. 58 (4), pp. 784-793. Date of Electronic Publication: 2018 Apr 11.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet

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Chemoselective Dual Labeling of Native and Recombinant Proteins.

• Authors : Agrawalla BK; Max-Planck-Institute for Polymer Research , Ackermannweg 10, 55128 Mainz, Germany.; Wang T

Subjects: Allyl Compounds/Allyl Compounds/Allyl Compounds/*chemistry ; Cysteine/Cysteine/Cysteine/*chemistry ; Maleimides/Maleimides/Maleimides/*chemistry

• Source: Bioconjugate chemistry [Bioconjug Chem] 2018 Jan 17; Vol. 29 (1), pp. 29-34. Date of Electronic Publication: 2017 Dec 20.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet

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Functional and molecular aspects of transient T cell unresponsiveness: role of selective interleukin-2 deficiency.

• Authors : Köller MD; Department Internal Medicine III, Division of Rheumatology, University of Vienna, Austria. ; Kiener HP

Subjects: Lymphocyte Activation* ; Proteins*; Autoimmune Diseases/Autoimmune Diseases/Autoimmune Diseases/*immunology

• Source: Clinical and experimental immunology [Clin Exp Immunol] 2003 May; Vol. 132 (2), pp. 225-31.Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Print ISSN: 0009-9104

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Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression.

• Authors : Iwashima M; Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912-2600, USA. ; Takamatsu M

Subjects: Adaptor Proteins, Signal Transducing* ; Adaptor Proteins, Vesicular Transport* ; Nuclear Proteins*

• Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2002 Apr 02; Vol. 99 (7), pp. 4544-9. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print

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SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.

• Authors : Cohney SJ; DNAX Research Institute, Palo Alto, California 94304, USA.; Sanden D

Subjects: Milk Proteins* ; Repressor Proteins* ; Transcription Factors*

• Source: Molecular and cellular biology [Mol Cell Biol] 1999 Jul; Vol. 19 (7), pp. 4980-8.Publisher: Taylor & Francis Country of Publication: United States NLM ID: 8109087 Publication Model: Print Cited Medium: Print ISSN: 0270-7306

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USAN Council. List No.405. New names. Denileukin Diftitox.

Subjects: Diphtheria Toxin* ; Interleukin-2* ; Terminology as Topic*

• Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 1998 Jun; Vol. 63 (6), pp. 704.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print Cited Medium: Print ISSN: 0009-9236 (Print)

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