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Subject : protein-tyrosine kinases
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Academic Journal

Discovery of selective TYK2 inhibitors: Design, synthesis, in vitro and in silico studies of promising hits with triazolopyrimidinone scaffold.

Subjects: *BINDING sites; *STAT proteins; *IN vitro studies

  • Source: Bioorganic Chemistry. Jul2024, Vol. 148, pN.PAG-N.PAG. 1p.

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Academic Journal

The role of STAT transcription factors in apoptosis regulation of hypothalamic neurons in aging in HER-2/neu transgenic mice and wild-type FVB/N mice.

Subjects: *STAT proteins; *APOPTOSIS; *HYPOTHALAMIC hormones

  • Source: Doklady Biochemistry & Biophysics. May2016, Vol. 468 Issue 1, p217-219. 3p.

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Academic Journal

KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway.

Subjects: *THERAPEUTIC use of antineoplastic agents; *STAT proteins; *IN vitro studies

  • Source: Cancers. Jan2024, Vol. 16 Issue 1, p9. 17p.

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Academic Journal

Target Occupancy and Functional Inhibition of JAK3 and TEC Family Kinases by Ritlecitinib in Healthy Adults: An Open‐Label, Phase 1 Study.

Subjects: *STAT proteins; *CLINICAL trials; *ORAL drug administration

  • Source: Journal of Clinical Pharmacology. Jan2024, Vol. 64 Issue 1, p67-79. 13p.

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Academic Journal

Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1.

Subjects: *IMIDAZOPYRIDINES; *STAT proteins; *LIVER cancer

  • Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2018, Vol. 33 Issue 1, p1248-1255. 8p.

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Academic Journal

STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation.

Subjects: GAIN-of-function mutations; CELLULAR signal transduction; IMMUNE response

  • Source: Turkish Journal of Immunology; 2024 Suppl 1, Vol. 12, p47-52, 6p

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Academic Journal

Potential Use of Janus Kinase Inhibitors in the Treatment of Systemic Lupus Erythematosus.

Subjects: KINASE inhibitors; SYSTEMIC lupus erythematosus; STAT proteins

  • Source: Journal of Inflammation Research; Apr2023, Vol. 16, p1471-1478, 8p

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Academic Journal

A novel approach to study multi-domain motions in JAK1's activation mechanism based on energy landscape.

Subjects: JANUS kinases; PROTEIN-tyrosine kinases; EZRIN

  • Source: Briefings in Bioinformatics; Mar2024, Vol. 25 Issue 2, p1-9, 9p

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Academic Journal

100: Mitochondrial STAT3 supports K-Ras driven myeloid leukaemia in vivo.

Subjects: *MITOCHONDRIAL DNA; *STAT proteins; *MYELOID leukemia

  • Source: Cytokine. Sep2013, Vol. 63 Issue 3, p266-267. 2p.

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Academic Journal

Expression of the JAK/STAT3/SOCS3 signaling pathway in herniated lumbar discs.

Subjects: *PROTEIN-tyrosine kinases; *STAT proteins; *SUPPRESSORS of cytokine signaling

  • Source: Neuroscience Letters. May2014, Vol. 569, p55-58. 4p.

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  • 1-10 of  599 results for ""STAT proteins""