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Academic Journal

The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells.

  • Authors : Chen-Deutsch X; Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.; Kutner A

Subjects: Amino Acid Chloromethyl Ketones/Amino Acid Chloromethyl Ketones/Amino Acid Chloromethyl Ketones/*pharmacology ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/*pathology

  • Source: Leukemia research [Leuk Res] 2012 Jul; Vol. 36 (7), pp. 884-8. Date of Electronic Publication: 2012 Apr 26.Publisher: Pergamon Press Country of Publication: England NLM ID: 7706787 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair.

Subjects: Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Apoptosis/Apoptosis/Apoptosis/*drug effects ; DNA Repair/DNA Repair/DNA Repair/*drug effects TP protocol

  • Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2013 Mar; Vol. 18 (3), pp. 347-60.Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print Cited Medium: Internet ISSN: 1573-675X

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Academic Journal

Polo-like kinase 1, a new therapeutic target in hepatocellular carcinoma.

  • Authors : Mok WC; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673, Singapore.; Wasser S

Subjects: Genetic Therapy*; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*enzymology ; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*therapy

  • Source: World journal of gastroenterology [World J Gastroenterol] 2012 Jul 21; Vol. 18 (27), pp. 3527-36.Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN:

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Editorial & Opinion

A role for caspase inhibitors in differentiation therapy of myeloid leukaemia.

Subjects: Amino Acid Chloromethyl Ketones/Amino Acid Chloromethyl Ketones/Amino Acid Chloromethyl Ketones/*pharmacology ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/*pathology

  • Source: Leukemia research [Leuk Res] 2012 Jul; Vol. 36 (7), pp. 808-10. Date of Electronic Publication: 2012 Apr 23.Publisher: Pergamon Press Country of Publication: England NLM ID: 7706787 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1α,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance.

  • Authors : Chen-Deutsch X; Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, Newark, NJ, USA.; Studzinski GP

Subjects: Cell Differentiation*; Cell Cycle Checkpoints/Cell Cycle Checkpoints/Cell Cycle Checkpoints/*drug effects ; Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/*pathology

  • Source: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2012 Apr 01; Vol. 11 (7), pp. 1364-73. Date of Electronic Publication: 2012 Apr 01.Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137841 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis.

  • Authors : Temkin V; Division of Rheumatology, Northwestern University Feinberg School of Medicine, 240 E. Huron, Suite 2300, Chicago, IL 60611, USA.; Huang Q

Subjects: Necrosis*; Adenosine Diphosphate/Adenosine Diphosphate/Adenosine Diphosphate/*metabolism ; Adenosine Triphosphate/Adenosine Triphosphate/Adenosine Triphosphate/*metabolism

  • Source: Molecular and cellular biology [Mol Cell Biol] 2006 Mar; Vol. 26 (6), pp. 2215-25.Publisher: Taylor & Francis Country of Publication: United States NLM ID: 8109087 Publication Model: Print Cited Medium: Print ISSN: 0270-7306

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Academic Journal

Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer.

  • Authors : Matsuzaki T; Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.; Yashiro M

Subjects: Adenocarcinoma, Scirrhous/Adenocarcinoma, Scirrhous/Adenocarcinoma, Scirrhous/*drug therapy ; Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Fluorouracil/Fluorouracil/Fluorouracil/*administration & dosage

  • Source: Cancer science [Cancer Sci] 2009 Dec; Vol. 100 (12), pp. 2402-10. Date of Electronic Publication: 2009 Aug 18.Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic

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Academic Journal

Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species.

  • Authors : May MJ; Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104, USA. ; Madge LA

Subjects: Apoptosis/Apoptosis/Apoptosis/*genetics ; Caspases/Caspases/Caspases/*metabolism ; Embryo, Mammalian/Embryo, Mammalian/Embryo, Mammalian/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2007 Jun 01; Vol. 282 (22), pp. 16105-16. Date of Electronic Publication: 2007 Apr 12.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons.

  • Authors : Zhang Y; XinHua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. ; Gu X

Subjects: Apoptosis/Apoptosis/Apoptosis/*drug effects ; Cerebral Cortex/Cerebral Cortex/Cerebral Cortex/*cytology ; Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/*physiology

  • Source: The European journal of neuroscience [Eur J Neurosci] 2007 Mar; Vol. 25 (5), pp. 1341-8.Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print Cited Medium: Print ISSN: 0953-816X (Print)

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Academic Journal

Macrophages but not smooth muscle cells undergo benzyloxycarbonyl-Val-Ala-DL-Asp(O-Methyl)-fluoromethylketone-induced nonapoptotic cell death depending on receptor-interacting protein 1 expression: implications for the stabilization of macrophage-rich atherosclerotic plaques.

  • Authors : Martinet W; Division of Pharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium. ; De Meyer GR

Subjects: Macrophages, Peritoneal*/Macrophages, Peritoneal*/Macrophages, Peritoneal*/drug effects ; Macrophages, Peritoneal*/Macrophages, Peritoneal*/Macrophages, Peritoneal*/metabolism ; Macrophages, Peritoneal*/Macrophages, Peritoneal*/Macrophages, Peritoneal*/ultrastructure

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2006 Jun; Vol. 317 (3), pp. 1356-64. Date of Electronic Publication: 2006 Mar 14.Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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  • 1-10 of  39 results for ""Amino Acid Chloromethyl Ketones""