Search Results

Calculations of the binding free energies of the Comprehensive in vitro Proarrhythmia Assay (CiPA) reference drugs to cardiac ion channels.

• Authors : Tatsuki Negami; Tohru Terada

Subjects: ION channels; CARDIOVASCULAR agents; PROARRHYTHMIA

• Source: Biophysics & Physicobiology; 2023, Vol. 20 Issue 2, p1-15, 15p

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In Silico Human Cardiomyocyte Action Potential Modeling: Exploring Ion Channel Input Combinations.

• Authors : Boulay, Emmanuel; Troncy, Eric; Jacquemet, Vincent

Subjects: ACTION potentials; ION channels; POTASSIUM channels

• Source: International Journal of Toxicology (Sage); Jul/Aug2024, Vol. 43 Issue 4, p357-367, 11p

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Identification and characterisation of functional Kir6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membrane.

• Authors : Brennan, Sean; Chen, Shen; Makwana, Samir

Subjects: ACTION potentials; POTASSIUM channels; PROARRHYTHMIA

• Source: British Journal of Pharmacology; Sep2024, Vol. 181 Issue 18, p3380-3400, 21p

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Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk.

• Authors : Johannesen, Lars; Vicente, Jose; Hosseini, Meisam

Subjects: PROARRHYTHMIA; HEART beat; ELECTROCARDIOGRAPHY

• Source: PLoS ONE; 12/30/2016, Vol. 11 Issue 12, p1-18, 18p

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Proarrhythmic potential of metoclopramide in a sensitive whole‐heart model.

• Authors : Wolfes, Julian; Ellermann, Christian; Burde, Sophie

Subjects: METOCLOPRAMIDE; DOPAMINE antagonists; POTASSIUM channelsNEW Zealand

• Source: Basic & Clinical Pharmacology & Toxicology; Jun2021, Vol. 128 Issue 6, p741-746, 6p

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Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives.

• Authors : Shah, Rashmi R

Subjects: PROARRHYTHMIA; ADENOSINE triphosphate; POTASSIUM channels

• Source: British Journal of Pharmacology; Jan2010, Vol. 159 Issue 1, p58-69, 12p

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Inhibition of hERG K channels by verapamil at physiological temperature: Implications for the CiPA Initiative.

Subjects: VENTRICULAR tachycardia; VERAPAMIL; ARRHYTHMIA

• Source: Drug Week; 12/29/2023, p930-930, 1p

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Ciprofloxacin induced acquired long QT syndrome.

• Authors : Belabyad, Sara; Lamhani, Meriem; Bezza, Sofia

Subjects: LONG QT syndrome; VENTRICULAR tachycardia; CIPROFLOXACIN

• Source: European Journal of Cardiovascular Medicine; 2021, Vol. 11 Issue 3, p8-8, 1p

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Anti-KCNQ1 K+ channel autoantibodies increase IKs current and are associated with QT interval shortening in dilated cardiomyopathy.

• Authors : Li, Jin; Seyler, Claudia; Wiedmann, Felix

Subjects: POTASSIUM channels; AUTOANTIBODIES; DILATED cardiomyopathy

• Source: Cardiovascular Research; Jun2013, Vol. 98 Issue 3, p496-503, 8p

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Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.

• Authors : Vicente, Jose; Johannesen, Lars; Hosseini, Meisam

Subjects: DRUG side effects; ELECTROCARDIOGRAPHY; BIOMARKERS

• Source: PLoS ONE; 12/30/2016, Vol. 11 Issue 12, p1-16, 16p

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